Many thanks to Espen Samuelsen for finding another commercially available probiotic that I was not aware of: Propionibacterium freudenreichii
It is available as NutriCology Allergy Research‘s Securil Propio-Fidus.
No, it’s not a psychoanalysis probiotic (the “Freud” in it’s name), it is actually used in making Emmental cheese!
So what do we know about it (apart from being used to make one of my favorite cheeses!)
- A unique in vivo experimental approach reveals metabolic adaptation of the probioticPropionibacterium freudenreichii to the colon environment. [2013]
“We observed drastic changes in the catabolism of sugars and amino-acids. Glycolysis, the Wood-Werkman cycle and the oxidative phosphorylation pathways were down-regulated but induction of specific carbohydrate catabolisms and alternative pathways were induced to produce NADH, NADPH, ATP and precursors (utilizing of propanediol, gluconate, lactate, purine and pyrimidine and amino-acids). Genes involved in stress response were down-regulated and genes specifically expressed during cell division were induced, suggesting that P. freudenreichii adapted its metabolism to the conditions encountered in the colon.” - 1,4-Dihydroxy-2-naphthoic acid from Propionibacterium freudenreichii reduces inflammation in interleukin-10-deficient mice with colitis by suppressing macrophage-derived proinflammatory cytokines. [2013]
- “PJS lowered intestinal immunoreactivity of TNF-α,” Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet. [2013]
- Plays nicely with Bifidobacterium! Evaluation of positive interaction for cell growth between Bifidobacterium adolescentis andPropionibacterium freudenreichii using a co-cultivation system with two microfiltration modules. [2013]
Looking at colitis
- Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo. [2010]
- Characteristic of milk whey culture with Propionibacterium freudenreichii ET-3 and its application to the inflammatory bowel disease therapy. [2007]
- Milk whey culture with Propionibacterium freudenreichii ET-3 is effective on the colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats. [2005]
- Propionibacterium freudenreichii component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing. [2006]
- Bifidogenic growth stimulator for the treatment of active ulcerative colitis: a pilot study. [2005]
Bottom line: If passes my baseline criteria for use with CFS — it is effective for IBS. “I approve this probiotic!”
- “Propionibacteria produce an interestingly wide range of functional biomolecules like B group vitamins, trehalose, conjugated linoleic acid, propionic acid, bacteriocins, bifidogenic factors etc. ” Multifaceted attributes of dairy propionibacteria: a review. [2012]
- Appears to help with B12 production! Vitamin B12 production from crude glycerol by Propionibacterium freudenreichii ssp. shermanii: optimization of medium composition through statistical experimental designs. [2012]
- Used in a probiotic mixture demonstrated to reduce IBS
- Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. [2012]
- Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota. [2008]
- Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. [2007]
- Clinical studies on alleviating the symptoms of irritable bowel syndrome. [2006]
- A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. [2005]
- A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. [2005]
Update – thanks to AM for doing further research and forwarding it.
- “During cheese production, Propionibacterium freudenreichii ferments lactate to form acetate, propionate and carbon dioxide. The Propionate is a salt of propionic acid. Propionic acid is an organic, carboxylic acid, and is strongly anti-fungal, and supplementation with P. freudenreichii can boost the localised Propionate levels in the GI tract and help to eliminate Candida albicans and other yeasts and moulds. The Propionic acid molecule is shown below.” “A bacterium used in the production of Emmental.” Genoscope. 16 Jan. 2008
- “The five common strains of Bifidobacter include B. infantis, B. adolescentis, B. bifidum, B. longum, and B. breve. [P. freudenreichii]…provides the food that allows growth of all Bifidobacteria, so your body can maintain its own unique, health-promoting combination of the different stains. The Bifidobacteria levels remain high in your gut only while they have adequate food and stimulation to grow. ‘ [1987]
- Propionibacterium freudenreichii ferments and converts lactate to form: propionic acid (which favors the growth of bifidobacteria) [1994]