Probiotics with Demonstrated Health Benefits and Other Gems

Tonight I found two gems that I wish to share

“The major effects of stress on gut physiology include:

  1. alterations in gastrointestinal motility;
  2. increase in visceral perception;
  3. changes in gastrointestinal secretion;
  4. increase in intestinal permeability;
  5. negative effects on regenerative capacity of gastrointestinal mucosa and mucosal blood flow; and
  6. negative effects on intestinal microbiota.

Mast cells (MC) are important effectors of brain-gut axis that translate the stress signals into the release of a wide range of neurotransmitters and proinflammatory cytokines,”[2011]

Histamine released from Mast Cells cause many of the symptoms of a Jarisch-Herxheimer reaction. So I was about to do a quick review of PubMed for candidates that reduced Mast Cell release:

  • Lactobacillus GG (LGG) [2014] – strong impact – Commercial Probiotic: Culturelle
  • L. salivarius HMI001 [2012]
  • L. casei Shirota (LCS)  [2012]
  • Lactobacillus plantarum depends on the specific strain — if not known, avoid
    • LS/07 CCM7766 [2015] – moderate impact
    • L. plantarum WCFS1 – INCREASES Mast Cell release [2012]

At this point of browsing PubMed, I discovered the 2014 article (World J Gastroenterol. 2014 Aug 28; 20(32): 11023–11032.) and it distracted me because it had some nice tables based on recent literature which warrants reposting.

Recommendations for probiotic use from [2014]

Clinical condition Effectiveness Organism


Infectious-adult-treatment A Saccharomyces boulardi, LGG
Infectious-childhood- treatment A LGG. Lactobacillus reuteri
Prevention of infection B S. boulardii, LGG
Prevention of AAD A S. boulardii, LGG, L. casei, L. bulgaricus, S. thermophilus
Treatment of recurrent CDAD B S. boulardii, LGG
Prevention of CDAD B LGG, S. boulardii


Preventing and maintaining remission A VSL#3
Induce remission C VSL#3

Ulcerative colitis

Inducing remission C Escherichia coli Nissle, VSL#3
Maintenance C E. coli Nissle, VSL#3
Crohn’s C E. coli Nissle, S. boulardii, LGG


B Bifidobacterium infantis
IBS C Bifidobacterium animalis, VSL#3, Lactobacillus plantarum
Immune response A LGG, Lactobacillus acidophilus, L. plantarum, Bifidobacterium lactis, Lactobacillus johnsonii


Atopic eczema assoc. with cow milk allergy
Treatment A LGG, B. lactis
Prevention A LGG, B. lactis
Radiation enteritis C VSL#3, L. acidophilus
Vaginosis and vaginitis C L. acidophilus, LGG, L. reuteri

Reproduced with permission from reference Floch et al[31].

  • An ‘‘A’’ recommendation is based on strong, positive, well-conducted, controlled studies in the primary literature, not abstract form;
  • A ’‘B’’ recommendation is based on positive, controlled studies but the presence of some negative studies;
  • A ‘‘C’’ recommendation is based on some positive studies.
  • IBD: Inflammatory bowel disease;
  • LGG: Lactobacillus GG;
  • S. boulardii: Saccharomyces boulardii.