Histamines, mast cells and probiotics – Revisited

In my last post I stumbled on a PubMed article that appears to identify two probiotics that should reduce histamines:

  • “We found that mice that received GG and PJS[Propionibacterium freudenreichii] exhibited significantly lower numbers of intestinal mast cells compared with control mice.”[2013]

The implied logic is simple, less mast cells in the intestines, the less histamines to release. When I had visited this item before, I was searching directly for histamines and probiotics.  Changing the search to probiotics and mast cells I came up with 47+ articles.  “Accordingly, subsets of patients with IBS show higher numbers and an increased activation of mucosal immunocytes, particularly mast cells. “[2012]

“Although the effect of probiotics on allergic responses is different depending on the strains, doses, and experimental protocols, animal studies generally …reduction of degranulated mast cells,” [2009]

From these articles, I found the following interesting reports:

Following on to  the prior post,  we end up with the following being a group of mast cell inhibitors that appears to be fine to take together.

  • Mutaflor (E. coli Nissle 1917) x Securil (Propionibacterium freudenreichii) Culturelle (Lactobacillus rhamnosus GG) x Yakult (Lactobacillus Casei)