A reader posted on facebook
” Hi Ken, have you heard anything about L. Salivarius being bad for CFS patients? I’m trying Custom Probiotics d-lactate-free formula at the moment. There’s a patient on the PhoenixRising forum who believes L. Salavirus permanently worsened their condition, and also claimed it can destroy beneficial bacteria a la antibiotics. Have you ever read anything along these lines?”
First thing is simple: L. Salivarius does kill other bacteria – the questions is whether it kills the good ones or the bad ones (or kills randomly!). The “antibiotic” that it produces is called a bacteriocin. “bacteriocins are being tested to assess their application as narrow-spectrum antibiotics.“
This may depend on the strain — unfortunately, the strain is often not put on to many commercial probiotics.
- “an up-to-date overview of all L. salivarius strains, isolated from different origins, known as bacteriocin producing and/or potential probiotic.” , from the complete article:
- … are producers of unmodified bacteriocin of subclasses IIa,IIb and IId…
- inhibits … Bacillus, Listeria, Enterococcus and Staphylococcus
- .. against Lactobacillys delbrueckii subsp bulgaricus (used in many yogurts)
- .. against Enterococcus faecalis, E. faecium and Neisseria gonorrhoeae
- .. against S. mutans, Streptococcus pneumoniae, Staphylococcus aureus, micrococcus flavus and Salmonella enteritidis
- … against Campylobacter jejuni
- .. active against more phylogenetically divergent Gram-positive bacteria and occasionally against Gram-negative bacteria.
- … against L.monocytogenes…
- Antibiotic susceptibility profiles showed that the strains of L. salivarius were sensitive to the majority of antibiotics tested..
- … induces Interleukin (IL)-10… IL-6
Studies on CFS/IBS/FM?
- On CFS – Zero
- On fibromyalgia – Zero
- On Irritable Bowel Disease
- Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease. “the data therefore suggest that this Lactobacillus subsp. has limited potential as a prophylactic or therapeutic treatment for inflammatory bowel disease”
There is no evidence that Lactobacillus salivarius is of any benefit to CFS/FM/IBS/IBD. Within the family is a wide spectrum of bacteriocins – and the lack of positive effects suggests that it does not invoke a shift that is desirable for these conditions. There is reasonable evidence that the report forwarded by a reader may be accurate/true.
I would rank lactobacillus salivarius as a “to be avoided” probiotic.