Chromolyn Sodium – a minor Christmas miracle for histamine issues?

A reader that I know personally have been struggling with odd challenges, especially sickness triggered by eating (within a minute). A good day was often 600 calories. The usual ‘useless’ round of both conventional and alternative physicians. The reader speech has been impacted, struggling to get a sentence out sslllooowwwwllllyyyy.

Atypical mast cell issues interacting with other medical issues appears to be the cause. Abnormal histamine release from eating was a target (deal with one symptom at a time).

The reader took inspiration from my researching PubMed, especially the older, not in fashion, treatmentsThe reader discovered Chromolyn Sodium. A classic asthma medication

PubMed

Almost all of the literature dealt with Asthma — it was an old treatment for Asthma.

On a very few sites, it is mentioned as Cromoglicic acid, a mast cell stabilizer. The reader does not have asthma.

The reader was able to persuade a traditional medical physician to prescribe a one month supply as solution ampoules . (The aerosol/nasal form appears to be available over the counter and on Amazon. One spray appears to be equivalent to one ampoules). Because it was a very atypical prescription in today’s market, the pharmacist insisted on speaking with the physician. After a few days, the prescription arrived: 120 ampoules to be taken 1 every 6 hours.

Witness

After just one day, speech has greatly improved, symptoms have reduced. The reader did admit that this could be just a placebo effect — but given how much they struggled with speech just yesterday, I doubt it.

More information

Going over to DrugBank, a nice resource. We can see it’s structure (
C23H16O11 ) and read a precise description. It was first marketed for Asthma in 1981.

A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

Cromoglicate inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Cromoglicate also may reduce the release of inflammatory leukotrienes. Cromoglicate may act by inhibiting calcium influx.



https://www.drugbank.ca/structures/small_molecule_drugs/DB01003

Gotcha’s

From Facebook feedback, some of the sprays have stabilizers which could cause adverse reactions. Checking with the reader cited above — the content had just two ingredients: sterilized water and Chromolyn Sodium.

Additional Items to Review

Using the sweet Canadian DrugBank, we have a list of alternative things to research (all Mast-cell stabilizers):

Bottom Line

Just sharing a little good news in this Christmas Season.