Misc Notes on the Microbiome

Proteins can cause a microbiome cascade that leads to disease

a neurologist at Johns Hopkins School of Medicine, and his team created an animal model of the disease by injecting particular proteins into the stomachs of mice. About a month later, the animals showed symptoms of Parkinson€  ’²s disease. The model not only demonstrates how the disease protein can travel up from the gut to the brain, but also presents nonmotor symptoms rarely seen in other animal models.

Source – It was not bacteria added, just proteins — which alter the microbiome and cascaded from there.

Commensal bacteria from the mouth, skin, and gut produce an ortholog of the human protein Ro60. Some of these bacteria and bacterial Ro60 activated T cells from the blood of a patient with lupus. Ro60-specific antibodies from lupus patients also bound to bacterial Ro60, suggesting commensals could have a hand in activating antibody-producing B cells involved in the autoimmune disease.

source – similar to above, bacteria produce proteins activate nasty things

Is this why ME/CFS are so tired?

Veillonella acts like a “metabolic sink” for lactate, the scientists suspect, converting into fuel the by-product of hard-working muscles runners blame for their aching legs in the latter part of long-distance races. The bacteria turn lactate into propionate, a short-chain fatty acid that’s a source of energy and can also be an anti-inflammatory, a Harvard-affiliated team of scientists reported Monday in Nature Medicine

source

Using our contributed data: LOW Veillonella is associated at a statistically significant level with:

  • General: Fatigue
  • Neurological-Audio: hypersensitivity to noise
  • Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS)
  • Neuroendocrine Manifestations: sweating episodes
  • Neuroendocrine Manifestations: intolerance of extremes of heat and cold
  • Immune Manifestations: tender lymph nodes
  • Immune Manifestations: general malaise
  • Sleep: Waking up early in the morning (e.g. 3 AM)
  • Autonomic: Dizziness or fainting
  • Post-exertional malaise: Post-exertional malaise
  • Post-exertional malaise: Next-day soreness after everyday activities
  • Official Diagnosis: Chronic Fatigue Syndrome

This suggests that the Veillonella probiotics being considered for fitness jocks may also cause a major improvement with ME/CFS. Until that happens, we have to depend on things that feed it and avoid items that diminish it. What is know is listed here.

Another important story

Given the immense antigenic load present in the microbiome, we hypothesized that microbiota mimotopes can be a persistent trigger in human autoimmunity via cross-reactivity. Using antiphospholipid syndrome (APS) as a model, we demonstrate cross-reactivity between non-orthologous mimotopes expressed by a common human gut commensal, Roseburia intestinalis ( R. int), and T and B cell autoepitopes in the APS autoantigen β 2-glycoprotein I (β 2GPI). 

source

As above, using our contributed data: HIGH Roseburia intestinalis is associated at a statistically significant level with:

  • General: Fatigue
  • Post-exertional malaise: Inappropriate loss of physical and mental stamina,
  • Sleep: Unrefreshed sleep
  • General: Myalgia (pain)
  • General: Headaches
  • Neurological: Impairment of concentration
  • Neurological: Short-term memory issues
  • Neurological: Word-finding problems
  • Neurological-Audio: hypersensitivity to noise
  • Neurological: emotional overload
  • Autonomic Manifestations: Orthostatic intolerance
  • Autonomic Manifestations: irritable bowel syndrome
  • Autonomic Manifestations: urinary frequency dysfunction
  • Post-exertional malaise: General
  • Neuroendocrine Manifestations: subnormal body temperature
  • Neuroendocrine Manifestations: cold extremities
  • Neuroendocrine Manifestations: intolerance of extremes of heat and cold
  • Neuroendocrine Manifestations: worsening of symptoms with stress.
  • Immune Manifestations: tender lymph nodes
  • Immune Manifestations: recurrent flu-like symptoms
  • Immune Manifestations: general malaise
  • Onset: Gradual
  • Neuroendocrine Manifestations: Muscle weakness
  • Neurological: Cognitive Overload
  • Neurological-Sleep: Insomnia
  • Immune Manifestations: Bloating
  • Neurological-Sleep: Night Sweats
  • Immune Manifestations: Hair loss
  • Neurological-Sleep: Inability for deep (delta) sleep
  • Neuroendocrine Manifestations: Rapid muscular fatiguability
  • Gender: Female
  • Sleep: Problems staying asleep
  • Sleep: Waking up early in the morning (e.g. 3 AM)
  • Pain: Pain or aching in muscles
  • Pain: Joint pain
  • Pain: Myofascial pain
  • Neuroendocrine: Cold limbs (e.g. arms, legs hands)
  • Neuroendocrine: Feeling hot or cold for no reason
  • Immune: Recurrent Sore throat
  • Immune: Sensitivity to smell/food/medication/chemicals
  • Neurocognitive: Problems remembering things
  • Neurocognitive: Difficulty paying attention for a long period of time
  • Neurocognitive: Can only focus on one thing at a time
  • Neurocognitive: Slowness of thought
  • Neurocognitive: Absent-mindedness or forgetfulness
  • Post-exertional malaise: Post-exertional malaise
  • Post-exertional malaise: Next-day soreness after everyday activities
  • Joint: Stiffness and swelling
  • Neurocognitive: Brain Fog

The CFS Researcher, Dave Berg back in 1999 wrote:

Our hypothesis is that a majority of individuals diagnosed as Chronic Fatigue Syndrome (CFS) &/or Fibromyalgia (FM) on clinical criteria may be defined as AntiPhospholipid Syndrome (APS) with the endothelial cell (EC) as the disease target with or without platelet activation (PA). 

Chronic Fatigue Syndrome (CFS) &/or Fibromyalgia (FM) 
as a Variation of Antiphospholipid Antibody Syndrome (APS): An Explanatory Model and Approach to Laboratory Diagnosis.
   BLOOD COAGULATION & FIBRINOLYSIS 1999,10:p 1 – 4. 

That’s it for the moment, more coming as time permits.