Histamine reducing probiotics

A reader asked not for probiotics that do not produces histamine (the usual ask), but ones that reduces histamine and mask cell issues. The following is what I could find in the literature. Mast cell issues are increasingly implicated with digestive issues. Release of histamine from mast cells cause inflammation.

” a growing body of publications clearly showed that patients with postinfectious IBS have increased Mast Cell [MC] activation… it has been recently demonstrated that dietary administration of S. cerevisiae‐derived β‐glucan was able to attenuate MC‐induced intestinal hyperpermeability in patients affected by Crohn’s disease ileitis as well as in noninflammatory IBD subjects,”

Mast cells at the crossroads of microbiota and IBD. [2018]

This article Mast cells at the crossroads of microbiota and IBD. [2018], lists some specific impacts. “several commensal bacteria such as Enterococcus fecalisLactobacillus paracaseii, and nonpathogenic Escherichia coli are able to suppress murine MC degranulation  “

  • Enterococcus faecalis – Suppression of IgE/Ag‐induced degranulation, Reduction of MC infiltration and serum IgE levels in a murine model of atopic dermatitis
  • Lactobacillus paracasei – Suppression of IgE/Ag‐induced degranulation
  • Escherichia coli – Suppression of IgE/Ag‐ and PMA/ionomycin‐induced degranulation
  • Saccharomyces cerevisiae – Attenuation of MC‐induced intestinal hyperpermeability

Oral administration of Clostridium butyricum CGMCC0313-1 reduces ovalbumin-induced allergic airway inflammation in mice.[2017]

Enterococcus faecium has some evidence;

Lactobacillus rhamnosus GG has some evidence

DNA Aspect

There are some mutations of DNA that can result in low levels of  DAO or diamine oxidase (what counteracts histamine). This can be a factor for histamine. See this site for how to look up in your 23andMe or Ancestry DNA.

Bottom Line

My personal recommendations, based on the literature (and ranked), are: