A reader asked not for probiotics that do not produces histamine (the usual ask), but ones that reduces histamine and mask cell issues. The following is what I could find in the literature. Mast cell issues are increasingly implicated with digestive issues. Release of histamine from mast cells cause inflammation.
” a growing body of publications clearly showed that patients with postinfectious IBS have increased Mast Cell [MC] activation… it has been recently demonstrated that dietary administration of S. cerevisiae‐derived β‐glucan was able to attenuate MC‐induced intestinal hyperpermeability in patients affected by Crohn’s disease ileitis as well as in noninflammatory IBD subjects,”
Mast cells at the crossroads of microbiota and IBD. [2018]
This article Mast cells at the crossroads of microbiota and IBD. [2018], lists some specific impacts. “several commensal bacteria such as Enterococcus fecalis, Lactobacillus paracaseii, and nonpathogenic Escherichia coli are able to suppress murine MC degranulation “
- Enterococcus faecalis – Suppression of IgE/Ag‐induced degranulation, Reduction of MC infiltration and serum IgE levels in a murine model of atopic dermatitis
- Lactobacillus paracasei – Suppression of IgE/Ag‐induced degranulation
- Escherichia coli – Suppression of IgE/Ag‐ and PMA/ionomycin‐induced degranulation
- Saccharomyces cerevisiae – Attenuation of MC‐induced intestinal hyperpermeability
Enterococcus faecium has some evidence;
Lactobacillus rhamnosus GG has some evidence
- INVESTIGATION OF PROTECTIVE EFFECTS OF SYNBIOTICS ON ALLERGOPATHY FORMATION. [2018]
- ” Compared with placebo, Lactobacillus rhamnosus GG (LGG) and VSL#3 were associated with significantly more treatment responders ( abdominal pain severity decreased ≥1 point on a 4-point Likert scale ) ” [2015]
- Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells. [2011] ” Our data suggest that especially probiotic L. rhamnosus Lc705 and L. rhamnosus GG could diminish mast-cell activation and the effects of allergy-related mediators by downregulating expression of the high-affinity IgE and HRH4 receptors, and by stimulating mast-cell immune responses “
DNA Aspect
There are some mutations of DNA that can result in low levels of DAO or diamine oxidase (what counteracts histamine). This can be a factor for histamine. See this site for how to look up in your 23andMe or Ancestry DNA.
Bottom Line
My personal recommendations, based on the literature (and ranked), are:
- Enterococcus faecalis
- symbiopharm / symbioflor 1
- shin biofermin (jp) /s
threelaccontains this but also contains a known histamine producer.
- Escherichia coli
- Lactobacillus paracasei
- Lactobacillus rhamnosus GG
CFS Remission 