Unknown's avatar lassesen 8:11 pm on July 18, 2024  

Suggest sequence and choice of Antibiotics if doing Jadin’s Protocol

A reader saw the new cross-validated suggestions for ME/CFS using his own microbiome. Cross validated means the item must meet two criteria:

  • They are computed by the expert system to correct bacteria shifts
  • They have been reported in studies to help people with ME/CFS (at least a study subset)

If interested, his cross validated suggestions are here.

He is exploring trying the Jadin Protocol (1 week of one antibiotic, 3 weeks off, then repeat for a different antibiotics). For more information see: Video Presentation of Dr. Jadin’s Current Protocol for ME/CFS, Q-Fever, Chronic Lyme and related conditions

He wanted to know which has the least risk — well, I have grown to trust Perplexity.Ai to give good answers (with the sources of information linked). The FULL ANSWER IS HERE (with References).

The preferences are with 1 being the lowest risk.

  1. Minocycline and 2. Doxycycline: These tetracyclines appear to have the lowest risk. The search results indicate that tetracyclines, particularly minocycline, have a low risk of adverse reactions. Minocycline had an adjusted odds ratio of 0.79 for community-acquired Clostridioides difficile infection (CA-CDI), while doxycycline had an adjusted odds ratio of 0.96, both lower than most other antibiotics.
  2. Neomycin: As an aminoglycoside, neomycin is likely to have a relatively low risk. The search results mention that aminoglycosides were classified among the safest antibiotics in terms of anaphylaxis risk.
  3. Metronidazole: While not specifically mentioned in the search results, metronidazole is generally considered to have a moderate risk profile.
  4. Azithromycin: This macrolide antibiotic had an adjusted odds ratio of 1.31 for CA-CDI, higher than tetracyclines but lower than other antibiotics on this list.
  5. Erythromycin: Another macrolide, erythromycin had a higher adjusted odds ratio of 1.53 for CA-CDI compared to azithromycin.
  6. Vancomycin: While not directly compared in the search results, vancomycin is known to have potential for significant adverse reactions, including nephrotoxicity and ototoxicity.
  7. Ampicillin: This penicillin antibiotic had one of the highest adjusted odds ratios for CA-CDI at 2.6, indicating a higher risk of adverse reactions.

As a FYI, a few decades ago, I persuaded my MD to give me Minocycline and Doxycycline by saying “Look you have no problem prescribing those to a teenager for acne — I have ME/CFS and on disability… are you saying that a teenager’s acne impacting their ability to get dates is more critical than ME/CFS? and being on disability?” I walked out with the prescriptions…..