I purchased a bottle of RESTORE a couple years back which was manufactured by Bionic Sciences LLC which is now ION* Gut Health and the company changed its name to Intelligence of Nature the ingredients of my RESTORE bottle says Aqueous Humid Substances ( Terrahydrate). 150mg per teaspoon and now the ingredients on the ION* bottle says Humic Extract from ancient soil 5mg per teaspoon … Are we talking about the same product here???
I proceeded to their site to see if they have any evidence. They linked to studies, I downloaded many of them:
My first impression is that we have gas-lighting here. It has not been peer-reviewed, but most people will not registered the “pending”. It has not been published.
Another of their studies seems like a deliberate attempt to mislead, iMedPub seems to be an attempt to mimic PubMed… Going to that site I see “All Published work is licensed under a Creative Commons Attribution 4.0 International License” and who owns that site is willfully hidden (checking its registration) and it is a “we publish anything for a fee site” – “Hence, the Journals operate solely through processing charges we receive from the authors and some academic/corporate sponsors. ‘[src]
So what is in it? They appear to have obfuscate the ingredients – Dropping the list and replacing it with a non-descript “Humic Extract (from Ancient Soil)”. In other words, I can get the same thing by just going to any National park and collecting some soil!!
The firm is my issue, not the concept. Studies have shown that results depend on the source/content of the humic acids. They have failed to provide scientific information on the content. They have failed to publish respectable studies and the studies on their site appears to be gas-lighting. Their prices is $72 for a 2 month supply… well, I can get 25 pounds of Granular Humic Acid Powder – 25lb Bag, for $20 from Walmart!
I have also commented in the past” A teaspoon of good soil will likely help many microbiome issues” (i.e. the hygiene hypothesis). Most of the bacillus probiotics are soil based bacteria.
This is a follow up to my blog post of Dec 30, 2021. Rosacea, Circulation and mild CFS. The person has tried the suggestions, and now we will attempt to see what the consequences are and the next set of suggestions.
Remember, the suggestions are based on mathematical modelling using clinical studies on study populations, so they may work or not work for individuals.
Reminder: I am a computer scientist and a statistician. I am not licensed to practice medicine, and where I live has strict laws about ‘appearing to practice medicine’. What I can do for readers is to write a public blog (anonymous) from your data and back story as an education post on using the software and the statistics it produces. I cannot consult. The content should be reviewed by a medical professional before implementing.
High Level Measures
Latest: 591 (38% increase in taxonomy)
Prior: Healthy 1, Unhealthy 8
Latest: Healthy 1, Unhealthy 9
Dr. Jason Hawrelak Recommendations
Prior: 99.7% (effectively excellent!)
Latest: 75.3%. What left ideal is below, nothing moved to ideal
My impression is that the microbiome has become more diverse, in one sense, unstable. The increase in the number of bacteria types reported (591) moved it just above the typical count for BiomeSight (578). My personal experience is that this is a good sign, the microbiome is changing, I experienced this spike is variety before my microbiome settled down into a new, healthier normal.
“This things has improved:
Seborrhoeic dermatitis is gone
Using the regression for all symptoms we had regressions for, we had 154 improved out of 209 items, or 74% had improvement in the prediction of symptoms.
Overall: Appears to be Improved
This person was a challenge originally because there was no dominate shifts or “smoking guns”. Being at the 99+% for Dr. Jason Hawrelak recommendations and the same items returned from other expert suggestions (many with more criteria) had no significant change. Supporting improvement: Increase in bacteria types closer to typical; significant decrease in number of Unhealthy Bacteria; improved symptoms; and last, prediction of symptoms had a major improvement.
Next Round of Suggestions
After the above sample, he actually started two more items:
10 days with doxycycline
started to take rosemary “Feels pretty good taking it. ”
The differences actually shocked me, a very very dramatic difference. On the current sample I see what is often on ME/CFS patients list appear at the top: miyarisan (jp) / miyarisan with also L. Plantarum Probiotic Powder. This suggests that he is moving towards/through a more typical ME/CFS microbiome. Given that he has issues but everything appeared normal or good, I take this as a good sign – we are exposing the issues.
We also have the option of probiotics based on symptoms (adjusted for the microbiome). See Using Samples and Symptoms to Suggest Probiotics post. The data is shown below in decreasing weight order. The nice thing to see is the decrease in the weight of everyone. One totally disappeared (the sole enterococcus faecalis one). It is interesting to note that while above using only the microbiome and resulted in major shifts between samples, when the symptoms are combined the suggestions are very similar and actually reflect improvement of the microbiome.
The person tried using the ME/CFS filter and got very different results. This person has mild ME/CFS; the studies on the US National Library of Medicine are for ME/CFS are typically severe and matches a yard of criteria for inclusion in the study. It is often not safe to use there filters when you self-diagnosis or are mild/controlled.
We saw improvements between the sample when this reader implemented some of the suggestions. Remember, the suggestions improves the odds, they do not guarantee nor is there any requirement or protocol to follow.
I am a computer scientist and a statistician. I am not licensed to practice medicine, and where I live has strict laws about ‘appearing to practice medicine’. What I can do for readers is to write a public blog (anonymous) from your data and back story as an education post on using the software and the statistics it produces. I cannot consult. The content should be reviewed by a medical professional before implementing.
35yr old, female with ME of around 15 years, Coeliac and Crohn’s diagnosed in 2014 plus simple temporal lobe seizures and endometriosis.
I have tested extremely extensively and most labs are generally normal with the exception of:
Prolactin- always slightly above high end of range
Lyme ELISA IgM positive but Blot negative (possibly cross-reactive with RF)
Rheumatoid factor – one point over upper range
LDH – consistently slightly above range
Aldolase – tested once, slightly above range
ALT – occasionally slightly above range
EBV – positive for past infection but never any evidence of reactivation
SIBO breath test positive for hydrogen only
I am really struggling with acne… I have been offered Lymecycline for the acne but don’t know if it’s worth the risk. I am currently on a 7-day course of Co-amoxiclav (amoxicillin + clavulanic acid) for an infected cyst (my Biome sample was taken before this).
I was able to control my crohn’s with an elemental diet, followed by strict paleo, then gradually reverting to a more relaxed diet. I did a course of oregano oil which was very harsh on the gut but it got rid of my constant bloating for the first time in my life (this came back and remains since reintroducing carbs). I’m 99.9% sure I’m on the autism spectrum. Interestingly, some of my autistic traits and my ME symptoms abate somewhat for a short period at the beginning of a cold virus (the first couple of days while fever is present). I had a similar temporary reaction to Sulforaphane.
My ME started while I was working full time, following glandular fever in 2006. The onset was characterised by ‘tired but wired’ and rolling PEM, finding it almost impossible to fall asleep until it was nearly time to get up and a complete inability to get into deep sleep. I reduced my working hours gradually but eventually gave up work fully in 2008. Even when ‘healthy’ I never had normal stamina, muscle mass and was really ready for bed by the end of the work day.
Possibly coinciding with my gastrointestinal diagnoses and subsequent avoidance of gluten, my symptoms calmed a bit from the ‘acute’ years, and I began to sleep a little better and get brief symptom-free interludes while at rest. Now, prolonged activity above baseline will lead to a return of the PEM and ‘tired but wired’ symptoms (inability to switch off nonsensical chattering thoughts at night leading to insomnia, feeling hot with chills, feverish, sweats, tossing and turning all night. These symptoms stop on rising but leave me extremely brain fogged from the sleep deprivation, and then repeat the next night. I also experience myalgia, headaches, orthostatic intolerance and strong need to lay horizontal throughout the day. I wake with heavy puffy face and eyelids most days. I go through periods of extreme dry mouth, worse on waking despite always hydrating well.
Even in my symptom-free-at-rest periods, I still struggle to get to sleep some nights, although I keep a strict routine 10pm-10am. I find it very difficult to get into the deeper stages of sleep almost all of the time. Even with all reasonable interventions and ear plugs I am easily startled awake by household sounds and there is usually activity from others from 4-5am onwards.
I am going to do three levels of Analysis. I will start with generic, then move on to diagnosis using US National Library of Medicine studies and ending with the latest refactor, using bacteria associated with symptoms discovered from uploads to this site. The purpose of these analysis to get suggestions for the most probable bacteria causing issues.
I will not go step by step (see this post with video for how to do this) but do the following suggestion generation and then look at the consensus
Both D-Ribose and Magnesium are well studied supplements in a ME/CFS context (confirming predictions to clinical practice the items are linked to CFSRemission Blog).
At this point I will stop for several reasons:
Purpose was to show the method
Person has brain fog often, so more notes may be counter productive
ME/CFS usually have restricted funds, so keeping the number of items low reduces frustrations over not being able to acquire.
A video will be added in the next few days
Questions And Answers
Q: I forgot to mention it, but I do have allergic rhinitis and high cholesterol (as listed under the detected conditions) so this is very accurate.
A: Although I see this often, it keeps surprising me about the accuracy of predictions!
Q: Interesting that it doesn’t pick up on any CFS-related bacteria at a species level, I wonder if this fluctuates and could possibly be because I was relatively low-symptom at the time of the sample, i.e. not in a PEM flare?
A: You are very likely correct, it does fluctuates. Also, keep in mind that there are many subsets of ME/CFS, so this can be a little hit-and-miss.
Should I take Lymecycline?
A: This is a little complex, we have mixed results.
But when I tried a different antibiotic often prescribed for acne, it is all positive
I would suggest making a counter proposal to your medical professional of minocycline instead.
Q: I’d be interested in your opinion on IgY hyperimmune egg powder supplements for targeting gut pathogens
A: There are many retail products like this. What I found are some vet studies[36 listed here]. I found a list of clinical studies here. My general impression is that it is favorable. There is one word of caution, it appears similar to transfer factor — i.e. the IgY may be targeted to specific bacteria/infections only. Hence, my advice would be to buy just one unit of it, if no response, change to a different brand when you finish it. Remember my motto: Rotate, rotate, rotate….
“Oral immunotherapy using egg yolk polyclonal IgYs against Eimeria sp. represents an effective and natural resource against severe E. tenella infection favoring the gradual withdrawal of the anticoccidial drugs and antibiotics.” 
Sue, a reader in Australia, shared her experience below on the challenge of taking supplements. Other people may have the same challenge. In some cases, retail products additives can be the source of problems. In this house, we tend to make our own or use additive free.
The problem began when Ken Lassesen’s brilliant AI came up with oils my daughter must take by swallowing them, with high probability of success. Coriander, thyme, lavender, perilla oils. She’s been sick to the point of house-bound for years, and we’ve got to get her into life. She has autism and chronic fatigue, and since 2018 Ken Lassesen’s AI has at least got her out of bed (unexpectedly, skads of licorice and thyme leaves are key players here) when no kindly, well-informed, hard-working doctor could achieve that.
So- where to get the oils? First call was to my excellent local pharmacy in Sydney – Newton’s – and they told me that their oils shouldn’t be ingested, but they’d heard of a place “somewhere in NSW” called “something like” TERRA, and they were “a bit expensive”. I found and rang TERRA, and they sent me the oils, one expensive from a company that’s licensed to provide ingestible oils, the other from a second company that I was assured was as good but hasn’t gone through the rigours of getting a license.
Now, how to get them into her. We tried dripping it into Bonvit gel caps from our local chemist with some “blotting paper” in the bottom of thiamine which she has to take anyway, but they disintegrated almost as we looked at them. Bonvit are fine with powders, but oils aren’t powders! Then we tried Surgipack’s capsules which were sturdier so they lasted until she put them in her mouth. A few seconds later, howls of pain.
Next morning we thought we had the solution and tracked down two sizes of Surgipack, so we put the oil and thiamine mixture into the smaller one and put that inside the bigger one, carefully wiping down the outside surface. We were very pleased with ourselves until a phone call with howls of pain with a burning oesophagus and stomach. I talked her into trying to take them right in the middle of breakfast, and she agreed to give them another go. It was still painful afterwards but she bravely soldiered on, saying that “it might be working” ! But after five days, the pain got too much to bear and she said she’d “never have that stuff again. However good it’s supposed to be”.
But there must be nasty meds taken all the time, so how do the commercial companies get them into people without the whole nation howling in pain, with mass revolts? They must know something we don’t.
We have a lot of private compounding chemists here so I rang around and asked them, one after another, if they used special capsules and could I buy some. But they make their money out of compounding, not selling their ingredients, so no. At last I chanced on a chatty girl who said what I needed was enteric-coated capsules”, but that her company couldn’t supply them. She vaguely mentioned legal reasons.
So then, the internet. We immediately found a supplier of enteric capsules in Australia, The Capsule Guy, costing $17 for 250 capsules. They come in sizes and we chose smallish ones, so we could put them inside a larger Surgipack capsule in case of dribbles.
We began 4 days ago. No howls. Then joy. Yesterday afternoon, her birthday, she went out to the party of a childhood friend who has the same birthday. She only stayed 3 hours before she wilted, but she went out and we are over the moon. Thank you, Ken. You are bringing our daughter into life.
Reading an account like this makes all of the hours that I spent on the blog and web site worthwhile. Thank you Sue for sharing! P.S. Sue started in 2018, it is not an overnight turnaround, it is a slow long march. Each person is unique, as is their microbiome. Microbiome Prescription is specific to an individual’s microbiome and not their diagnosis. The microbiome changes, hence retesting every few months is strongly encouraged.