A reader saw the new cross-validated suggestions for ME/CFS using his own microbiome. Cross validated means the item must meet two criteria:

• They are computed by the expert system to correct bacteria shifts
• They have been reported in studies to help people with ME/CFS (at least a study subset)

If interested, his cross validated suggestions are here.

He is exploring trying the Jadin Protocol (1 week of one antibiotic, 3 weeks off, then repeat for a different antibiotics). For more information see: Video Presentation of Dr. Jadin’s Current Protocol for ME/CFS, Q-Fever, Chronic Lyme and related conditions

He wanted to know which has the least risk — well, I have grown to trust Perplexity.Ai to give good answers (with the sources of information linked). The FULL ANSWER IS HERE (with References).

The preferences are with 1 being the lowest risk.

1. Minocycline and 2. Doxycycline: These tetracyclines appear to have the lowest risk. The search results indicate that tetracyclines, particularly minocycline, have a low risk of adverse reactions. Minocycline had an adjusted odds ratio of 0.79 for community-acquired Clostridioides difficile infection (CA-CDI), while doxycycline had an adjusted odds ratio of 0.96, both lower than most other antibiotics.
2. Neomycin: As an aminoglycoside, neomycin is likely to have a relatively low risk. The search results mention that aminoglycosides were classified among the safest antibiotics in terms of anaphylaxis risk.
3. Metronidazole: While not specifically mentioned in the search results, metronidazole is generally considered to have a moderate risk profile.
4. Azithromycin: This macrolide antibiotic had an adjusted odds ratio of 1.31 for CA-CDI, higher than tetracyclines but lower than other antibiotics on this list.
5. Erythromycin: Another macrolide, erythromycin had a higher adjusted odds ratio of 1.53 for CA-CDI compared to azithromycin.
6. Vancomycin: While not directly compared in the search results, vancomycin is known to have potential for significant adverse reactions, including nephrotoxicity and ototoxicity.
7. Ampicillin: This penicillin antibiotic had one of the highest adjusted odds ratios for CA-CDI at 2.6, indicating a higher risk of adverse reactions.

As a FYI, a few decades ago, I persuaded my MD to give me Minocycline and Doxycycline by saying “Look you have no problem prescribing those to a teenager for acne — I have ME/CFS and on disability… are you saying that a teenager’s acne impacting their ability to get dates is more critical than ME/CFS? and being on disability?” I walked out with the prescriptions…..

This uses the consensus model and does the following:

• Identifies the bacteria shifts reported in the literature that are seen in your microbiome sample
• Computes substances that should improve those shifts
• FILTER these substances using the literature of what helps the condition.

So, you have a list of things to fix the microbiome that are also known to help the condition. Many studies find that only a portion of people are helped. Our hypothesis is that the microbiome is a key factor here.

Last we give the top other suggestions (in general, they have never been tested in a clinical study — and thus we are depending on the microbiome impact)

After this, we give a list of studies used to generate the report. This should buy creditability with MD for what is being done as well as educate them.

This new suggestions report also handles multiple conditions. The example below is for someone that has both Autism and ME/CFS. It gives a good illustration of the new report intent.

The list of items reported to help ME/CFS is here with the studies the items are cited in.

This report is for Private@Annon.comand uses their reported medical conditions, microbiome sample and a fuzzy logic expert system to compute recommendations

The reported condition(s) are

1. Autism –
   Common Advice:
   1. Omega-3 Fatty Acids: Some studies have explored omega-3 supplements (particularly those containing EPA and DHA) due to their potential neuroprotective and anti-inflammatory properties. While research results have been mixed, some parents or caregivers of individuals with ASD might consider omega-3 supplements based on the belief that they could positively impact cognitive and behavioral functions.
   2. Probiotics: The gut-brain connection has sparked interest in the potential role of probiotics in influencing behavior and cognition. Some studies suggest that gut health might affect certain aspects of behavior in individuals with ASD. However, the use of probiotics for managing autism symptoms lacks robust scientific evidence, and their effectiveness remains unclear.
   3. Vitamin D: Low vitamin D levels have been observed in some individuals with ASD. While research is ongoing, maintaining adequate vitamin D levels is considered important for overall health. Some parents may opt for vitamin D supplements under the guidance of a healthcare professional.
   4. Multivitamins and Minerals: Individuals with ASD might have specific dietary habits that could lead to deficiencies in certain vitamins or minerals. Ensuring a balanced diet or supplementing with multivitamins and minerals under the guidance of a healthcare provider might be considered to address potential deficiencies.
2. Chronic Fatigue Syndrome – CFS,ME,Myalgic encephalomyelitis
   Common Advice:
   1. Coenzyme Q10 (CoQ10): Some studies have suggested that CoQ10 supplementation might have potential benefits in reducing fatigue and improving energy levels in individuals with CFS. However, more research is needed to establish its effectiveness for CFS specifically.
   2. Omega-3 Fatty Acids: Omega-3 supplements containing EPA and DHA have anti-inflammatory properties and may support overall health. Some individuals with CFS might consider omega-3 supplementation for potential benefits, although evidence supporting their use specifically for CFS is limited.
   3. Probiotics: The role of probiotics in managing CFS symptoms is an area of ongoing research. Some studies suggest that probiotics might impact gut health and the immune system, which could potentially affect symptoms in some individuals with CFS. However, specific probiotic strains, dosages, and their efficacy for CFS require further investigation.
   4. Vitamins and Minerals: Nutritional deficiencies are common in individuals with CFS, possibly due to poor dietary intake or other factors. Some individuals might have deficiencies in vitamins (such as vitamin D, B vitamins) or minerals (like magnesium or iron). Supplements might be recommended to address identified deficiencies.

Significant Bacteria Shifts

Based on the existing literature on the US National Library of Medicine and this microbiome sample, we have the following matches of bacteria shifts. There is a growing body of literature finding that the effectiveness of interventions depends on the existing microbiome. We filter by suggested interventions and this person’s specific microbiome to produce this “double validated” list..

Cross Validated Suggestions

The following improves the bacteria identified above and also is reported in the literature of helping some people with this condition. Each is link to the source study.

Suggestions Impact by Bacteria

Reviewing substances reported to help with this condition on the US National Library of Medicine, and which will correct the above bacteria shifts. the following are recommended. Some bacteria may lack literature because none of the studied substances for the condition(s) are known to modify the bacteria.

• Acidobacteriota
  • lactobacillus reuteri (probiotics) ^64 566
• Actinomycetota
  • Astragalus ^71 715
  • Coenzyme Q10 ^33 756
  • fructo-oligosaccharides (prebiotic) ^{56 61 72 87 89 98 105 536 756}
  • inulin (prebiotic) ^64 557
  • lactobacillus paracasei (probiotics) ^{61 64 631 772}
  • lactobacillus plantarum (probiotics) ^36 494
  • low fodmap diet ^{36 37 58 59 60 75 260 494 617}
  • minocycline (antibiotic)s[CFS] ^65 107
  • selenium ^{66 72 107 664}
  • Tryptophan ^{72 87 88 632 664}
  • vitamin d ^38 731
• Akkermansia
  • (r)-propranolol hydrochloride,(prescription) ^{38 45 46 72 76 94 308 731 773}
  • aripiprazole,(prescription) ^55 308
  • azithromycin,(antibiotic)s[CFS] ^70 119
  • doxepin hydrochloride,(prescription) ^70 76 308
  • doxycycline (antibiotic)s[CFS] ^67 308
  • erythromycin (antibiotic)s[CFS] ^68 308
  • Far infrared Sauna ^82 662
  • iron ^{72 83 84 85 438 662}
  • ketotifen fumarate,(prescription) ^72 308
  • lactobacillus plantarum (probiotics) ^{36 74 236 308}
  • lactobacillus reuteri (probiotics) ^{36 37 58 59 60 64 236 532 569 746 763}
  • liothyronine,(prescription) ^74 308
  • maprotiline hydrochloride,(prescription) ^100 308
  • melatonin supplement ^72 308
  • minocycline (antibiotic)s[CFS] ^65 76 308
  • omega-3 fatty acids ^{35 66 260 308}
  • resveratrol (grape seed/polyphenols/red wine) ^{38 43 44 54 72 212 260}
  • risperidone,(prescription) ^55 308
  • trazodone hydrochloride,(prescription) ^72 308
  • Vitamin B1,thiamine hydrochloride ^76 91 308
  • Vitamin B9,folic acid ^{27 92 93 308}
  • zinc ^{27 28 29 30 72 86 308 438}
• Akkermansia muciniphila
  • (r)-propranolol hydrochloride,(prescription) ^76 308
  • aripiprazole,(prescription) ^55 308
  • azithromycin,(antibiotic)s[CFS] ^70 119
  • doxepin hydrochloride,(prescription) ^70 76 308
  • doxycycline (antibiotic)s[CFS] ^67 308
  • erythromycin (antibiotic)s[CFS] ^68 308
  • Far infrared Sauna ^82 662
  • iron ^{72 83 84 85 438 662}
  • ketotifen fumarate,(prescription) ^72 308
  • lactobacillus plantarum (probiotics) ^{36 74 236 308}
  • lactobacillus reuteri (probiotics) ^{36 37 58 59 60 64 236 532 746 763}
  • liothyronine,(prescription) ^74 308
  • maprotiline hydrochloride,(prescription) ^100 308
  • melatonin supplement ^72 308
  • minocycline (antibiotic)s[CFS] ^65 76 308
  • omega-3 fatty acids ^{35 66 260 308}
  • resveratrol (grape seed/polyphenols/red wine) ^{38 43 44 54 72 212 260}
  • risperidone,(prescription) ^55 308
  • trazodone hydrochloride,(prescription) ^72 308
  • Vitamin B1,thiamine hydrochloride ^76 91 308
  • Vitamin B9,folic acid ^{27 92 93 308}
  • zinc ^{27 28 29 30 72 86 308 438}
• Alcaligenaceae
  • azithromycin,(antibiotic)s[CFS] ^70 521
• Bacteroides ovatus
  • azithromycin,(antibiotic)s[CFS] ^70 308
  • bifidobacterium infantis,(probiotics) ^{61 70 265 709}
  • Cacao ^{33 62 139 265}
  • doxepin hydrochloride,(prescription) ^{33 76 104 139 308 561}
  • doxycycline (antibiotic)s[CFS] ^67 270
  • erythromycin (antibiotic)s[CFS] ^{67 68 308 709}
  • folinic acid calcium salt,(prescription) ^{38 68 308 709}
  • fructo-oligosaccharides (prebiotic) ^{41 42 61 308 336}
  • glycyrrhizic acid (licorice) ^{61 101 384 548}
  • guanfacine hydrochloride,(prescription) ^{76 102 103 308 548}
  • iron ^72 438
  • lactobacillus plantarum (probiotics) ^36 581
  • lactobacillus reuteri (probiotics) ^{37 58 59 60 64 315 581}
  • liothyronine,(prescription) ^{64 74 308 532}
  • melatonin supplement ^72 308
  • minocycline (antibiotic)s[CFS] ^{65 76 270 308}
  • momordia charantia(bitter melon, karela, balsam pear, or bitter gourd) ^{65 66 90 260 270 308}
  • N-Acetyl Cysteine (NAC), ^57 548
  • resveratrol (grape seed/polyphenols/red wine) ^{54 72 152 548}
  • ß-glucan ^{54 69 260 381 394}
  • Vitamin B1,thiamine hydrochloride ^91 308
  • Vitamin B9,folic acid ^{27 92 93 308 438}
  • vitamin d ^{28 29 30 38 72 86 438 775}
• Bacteroides uniformis
  • aripiprazole,(prescription) ^{45 46 55 72 94 308 775}
  • azithromycin,(antibiotic)s[CFS] ^70 308
  • bifidobacterium infantis,(probiotics) ^{61 70 265 709}
  • Cacao ^{33 62 139 265}
  • doxepin hydrochloride,(prescription) ^{76 104 139 308}
  • doxycycline (antibiotic)s[CFS] ^67 270
  • erythromycin (antibiotic)s[CFS] ^{67 68 308 709}
  • fructo-oligosaccharides (prebiotic) ^{61 68 336 709}
  • glycyrrhizic acid (licorice) ^{61 101 384 548}
  • guanfacine hydrochloride,(prescription) ^{76 102 103 308 548}
  • lactobacillus plantarum (probiotics) ^36 581
  • lactobacillus reuteri (probiotics) ^{37 58 59 60 64 315 581}
  • maprotiline hydrochloride,(prescription) ^{64 100 308 532}
  • melatonin supplement ^72 308
  • minocycline (antibiotic)s[CFS] ^{65 76 270 308}
  • momordia charantia(bitter melon, karela, balsam pear, or bitter gourd) ^{65 66 90 260 270 308}
  • N-Acetyl Cysteine (NAC), ^57 548
  • naltrexone hydrochloride dihydrate,(prescription) LDN ^72 308 548
  • resveratrol (grape seed/polyphenols/red wine) ^{54 74 77 152 308}
  • risperidone,(prescription) ^{54 55 308 381 394}
  • ß-glucan ^69 260
  • trazodone hydrochloride,(prescription) ^72 308
  • Vitamin B9,folic acid ^{27 76 308 438}
  • vitamin d ^{28 29 30 38 72 86 438 775}
• Citrobacter
  • azithromycin,(antibiotic)s[CFS] ^{45 46 70 72 94 119 775}
  • bifidobacterium infantis,(probiotics) ^61 497
  • bifidobacterium lactis bb12 (probiotics) ^{61 62 324 497}
  • fructo-oligosaccharides (prebiotic) ^{61 63 313 324}
  • inulin (prebiotic) ^{61 64 136 323}
  • iron ^{64 72 371 392}
  • lactobacillus paracasei (probiotics) ^61 361
  • lactobacillus plantarum (probiotics) ^{36 61 158 435}
  • lactobacillus reuteri (probiotics) ^{36 37 58 59 60 64 158 171 187 233 364 502 581}
  • lactobacillus rhamnosus (probiotics) ^{61 64 288 315 372 440}
  • minocycline (antibiotic)s[CFS] ^65 457
  • resveratrol (grape seed/polyphenols/red wine) ^{54 66 348 457}
  • selenium ^72 128
  • Sulforaphane (In broccoli sprouts,cauliflower, kale, cole crops, cabbage, collards, mustard, and cress) ^{38 72 87 88 128 377 678}
  • Vitamin B-12 ^{38 39 49 50 51 52 53 199 678}
  • vitamin d ^{38 47 48 72 173 199}
  • zinc ^{45 46 72 94 173 343}
• Coprococcus
  • fructo-oligosaccharides (prebiotic) ^{61 72 159 377}
  • glycyrrhizic acid (licorice) ^{61 101 201 743}
  • inulin (prebiotic) ^{64 102 103 205 743}
  • iron ^{64 72 290 292 332 365 371 482 489 772}
  • lactobacillus paracasei (probiotics) ^{61 72 155 438}
  • lactobacillus plantarum (probiotics) ^{36 61 158 626}
  • lactobacillus reuteri (probiotics) ^{36 37 58 59 60 64 158 191 644 746}
  • lactobacillus rhamnosus (probiotics) ^{61 64 393 532}
  • melatonin supplement ^72 708
  • minocycline (antibiotic)s[CFS] ^{65 76 107 708}
  • omega-3 fatty acids ^{35 65 66 107 193 506}
  • resveratrol (grape seed/polyphenols/red wine) ^{35 38 43 44 54 72 506 512 520}
  • Tryptophan ^72 632
  • Vitamin B9,folic acid ^27 438
  • vitamin d ^{28 29 30 38 72 86 438 601}
• Dorea
  • bifidobacterium infantis,(probiotics) ^{38 45 46 61 72 94 508 601 641 731 773 774}
  • fructo-oligosaccharides (prebiotic) ^{61 62 159 508}
  • glycyrrhizic acid (licorice) ^{61 101 201 743}
  • inulin (prebiotic) ^{64 102 103 205 743}
  • iron ^{64 72 290 292 332 365 371 489 772}
  • lactobacillus paracasei (probiotics) ^61 626
  • lactobacillus plantarum (probiotics) ^36 158
  • lactobacillus reuteri (probiotics) ^{36 37 58 59 60 64 158 191 644 746}
  • lactobacillus rhamnosus (probiotics) ^{61 64 393 532}
  • melatonin supplement ^72 708
  • minocycline (antibiotic)s[CFS] ^{65 76 107 708}
  • omega-3 fatty acids ^{35 65 66 107 193 506}
  • resveratrol (grape seed/polyphenols/red wine) ^{35 38 43 44 54 72 506 512 520}
  • Tryptophan ^72 632
  • vitamin d ^38 601
• Eggerthella
  • colostrum ^{38 45 46 62 72 94 601 731 738}
  • resveratrol (grape seed/polyphenols/red wine) ^54 138
  • vitamin d ^38 164
• Escherichia
  • azithromycin,(antibiotic)s[CFS] ^{45 46 70 72 94 164 269}
  • doxycycline (antibiotic)s[CFS] ^67 121
  • d-ribose ^{34 67 609 732}
  • erythromycin (antibiotic)s[CFS] ^{34 35 68 72 609 675 732}
  • fructo-oligosaccharides (prebiotic) ^61 159
  • inulin (prebiotic) ^{61 64 354 772}
  • iron ^72 438
  • minocycline (antibiotic)s[CFS] ^{65 72 133 580}
  • resveratrol (grape seed/polyphenols/red wine) ^{54 66 133 334}
  • risperidone,(prescription) ^55 433
  • SAM-e ^31 585
  • Vitamin B9,folic acid ^27 438
  • vitamin d ^{28 29 30 38 72 86 438 571}
  • zinc ^{45 46 72 94 130 571}
• Faecalibacterium
  • azithromycin,(antibiotic)s[CFS] ^{70 72 269 438}
  • colostrum ^62 738
  • fructo-oligosaccharides (prebiotic) ^61 260
  • inulin (prebiotic) ^64 537
  • iron ^{64 72 264 772}
  • lactobacillus paracasei (probiotics) ^61 155
  • lactobacillus plantarum (probiotics) ^36 236
  • lactobacillus rhamnosus (probiotics) ^{37 58 59 60 61 222 236}
  • low fodmap diet ^{61 75 260 372}
  • omega-3 fatty acids ^35 260
  • vitamin d ^{35 38 43 44 72 260 506 652}
  • zinc ^{45 46 72 94 237 652}
• Oscillospiraceae
  • azithromycin,(antibiotic)s[CFS] ^70 269
  • colostrum ^62 738
  • doxycycline (antibiotic)s[CFS] ^67 121
  • fructo-oligosaccharides (prebiotic) ^61 414
  • glycyrrhizic acid (licorice) ^{61 101 516 743}
  • inulin (prebiotic) ^{64 102 103 290 743}
  • iron ^{64 72 264 537 772}
  • lactobacillus paracasei (probiotics) ^61 155
  • lactobacillus plantarum (probiotics) ^{36 61 236 635}
  • lactobacillus reuteri (probiotics) ^{37 58 59 60 64 236 532}
  • lactobacillus rhamnosus (probiotics) ^61 372
  • omega-3 fatty acids ^35 506
  • resveratrol (grape seed/polyphenols/red wine) ^{38 43 44 54 72 506 696}
  • Vitamin B1,thiamine hydrochloride ^{54 91 235 699}
  • Vitamin B9,folic acid ^{27 92 93 235 691}
  • vitamin d ^{28 29 30 38 72 86 616 691}
  • zinc ^{38 45 46 72 94 237 616 652 773 774}
• Phascolarctobacterium
  • fructo-oligosaccharides (prebiotic) ^61 414
  • inulin (prebiotic) ^64 332
• Phocaeicola vulgatus
  • bifidobacterium lactis bb12 (probiotics) ^{61 64 161 772}
  • doxycycline (antibiotic)s[CFS] ^{63 67 121 161}
  • fructo-oligosaccharides (prebiotic) ^61 260
  • inulin (prebiotic) ^64 365
  • iron ^72 371
  • lactobacillus plantarum (probiotics) ^{36 72 232 438}
  • lactobacillus rhamnosus (probiotics) ^{36 37 58 59 60 61 232 236 372}
  • minocycline (antibiotic)s[CFS] ^65 107
  • resveratrol (grape seed/polyphenols/red wine) ^{54 66 107 146}
  • Vitamin B9,folic acid ^{27 54 212 262 387 438}
  • vitamin d ^{28 29 30 38 72 86 164 438}
• Pseudomonadaceae
  • Astragalus ^{45 46 71 72 94 164 548}
  • erythromycin (antibiotic)s[CFS] ^{68 71 260 716}
  • glycyrrhizic acid (licorice) ^101 548
  • iron ^{72 102 103 499 548}
  • lactobacillus reuteri (probiotics) ^{64 72 548 639}
• Pseudomonas
  • Astragalus ^71 548
  • erythromycin (antibiotic)s[CFS] ^{68 71 260 716}
  • glycyrrhizic acid (licorice) ^101 548
  • iron ^{72 102 103 499 548}
  • lactobacillus reuteri (probiotics) ^{64 72 548 639}
• Ruminococcaceae
  • azithromycin,(antibiotic)s[CFS] ^70 269
  • doxycycline (antibiotic)s[CFS] ^67 121
  • fructo-oligosaccharides (prebiotic) ^61 260
  • glycyrrhizic acid (licorice) ^101 743
  • iron ^{72 102 103 264 743}
  • lactobacillus paracasei (probiotics) ^61 155
  • lactobacillus rhamnosus (probiotics) ^61 222
  • low fodmap diet ^{61 75 260 372}
  • omega-3 fatty acids ^35 260
  • Vitamin B9,folic acid ^{27 38 43 44 72 260 691}
  • zinc ^{28 29 30 72 86 237 691}
• Staphylococcus
  • Astragalus ^71 548
  • lactobacillus plantarum (probiotics) ^36 158
  • lactobacillus reuteri (probiotics) ^{37 58 59 60 64 158 548}
  • vitamin d ^38 571
• Sutterella
  • azithromycin,(antibiotic)s[CFS] ^{45 46 70 72 94 229 571}
  • lactobacillus paracasei (probiotics) ^61 635
  • lactobacillus plantarum (probiotics) ^36 236
  • lactobacillus reuteri (probiotics) ^{37 58 59 60 64 236 532}
• Sutterellaceae
  • azithromycin,(antibiotic)s[CFS] ^70 229
  • inulin (prebiotic) ^64 772
  • lactobacillus paracasei (probiotics) ^61 635
  • lactobacillus plantarum (probiotics) ^36 236
  • lactobacillus reuteri (probiotics) ^{37 58 59 60 64 236 532}
• Veillonellaceae
  • d-ribose ^34 522
  • inulin (prebiotic) ^{34 35 64 72 283 522 523 524}
  • lactobacillus paracasei (probiotics) ^{61 64 392 635}
  • lactobacillus reuteri (probiotics) ^64 171
  • ß-glucan ^69 362
  • vitamin d ^38 731

Additional Suggestions

There are many other interventions to correct the bacteria shifts seen with this person. The top 20 suggestions are listed below as the top 20 items to avoid.

Reference

The following is a partial list of the critical citations used above.¹New evidences on the altered gut microbiota in autism spectrum disorders.
²The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism.
³Analysis of gut microbiota profiles and microbe-disease associations in children with autism spectrum disorders in China.
⁴Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified.
⁵Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome.
⁶Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder.
⁷Can we reduce autism-related gastrointestinal and behavior problems by gut microbiota based dietary modulation? A review.
⁸The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD.
⁹Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
¹⁰Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador.
¹¹Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder.
¹²Autism spectrum disorder is associated with gut microbiota disorder in children.
¹³[Correlation between gut microbiota and behavior symptoms in children with autism spectrum disorder].
¹⁴Changes in the Gut Microbiota of Children with Autism Spectrum Disorder.
¹⁵Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder.
¹⁶Gut Microbial Dysbiosis in Indian Children with Autism Spectrum Disorders.
¹⁷Potential role of microbiome in Chronic Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME).
¹⁸Altered Gut Microbiota in Korean Children with Autism Spectrum Disorders.
¹⁹Are Fecal Metabolome and Microbiota Profiles Correlated with Autism Severity? A Cross-Sectional Study on ASD Preschoolers.
²⁰Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder.
²¹Mucosa-associated specific bacterial species disrupt the intestinal epithelial barrier in the autism phenome.
²²Autism Spectrum Disorders and the Gut Microbiota.
²³Altered Gut Microbiota and Short-chain Fatty Acids in Chinese Children with Constipated Autism Spectrum Disorder.
²⁴Machine Learning Algorithms Applied to Predict Autism Spectrum Disorder Based on Gut Microbiome Composition.
²⁵The Role of Short-Chain Fatty Acids and Altered Microbiota Composition in Autism Spectrum Disorder: A Comprehensive Literature Review.
²⁶Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
²⁷Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
²⁸[Vitamin B12 and chronic fatigue].
²⁹[Vitamin B12, chronic fatigue and injection treatment].
³⁰Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
³¹Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.
³²Cognitive behaviour therapy for the chronic fatigue syndrome. Evening primrose oil and magnesium have been shown to be effective.
³³Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.
³⁴The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.
³⁵Role of dietary modification in alleviating chronic fatigue syndrome symptoms: a systematic review.
³⁶Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial.
³⁷Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience.
³⁸Dietary Supplement for Core Symptoms of Autism Spectrum Disorder: Where Are We Now and Where Should We Go?
³⁹Effect of camel milk on thymus and activation-regulated chemokine in autistic children: double-blind study.
⁴⁰Camel Milk as a Potential Therapy as an Antioxidant in Autism Spectrum Disorder (ASD).
⁴¹Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups.
⁴²Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial.
⁴³Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial.
⁴⁴Internet-based, randomized, controlled trial of omega-3 fatty acids for hyperactivity in autism.
⁴⁵Retraction: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder.
⁴⁶Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children.
⁴⁷Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.
⁴⁸Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism.
⁴⁹Sulforaphane treatment for autism spectrum disorder: A systematic review.
⁵⁰Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood.
⁵¹Sulforaphane treatment of autism spectrum disorder (ASD).
⁵²Sulforaphane treatment of autism spectrum disorder (ASD).
⁵³Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial.
⁵⁴Resveratrol as adjunctive therapy in treatment of irritability in children with autism: A double-blind and placebo-controlled randomized trial.
⁵⁵Aripiprazole for the treatment of irritability associated with autism.
⁵⁶Coenzyme Q(10) supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders.
⁵⁷N-acetylcysteine as an adjunctive therapy to risperidone for treatment of irritability in autism: a randomized, double-blind, placebo-controlled clinical trial of efficacy and safety.
⁵⁸Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of Lactiplantibacillus plantarum intervention.
⁵⁹Lactiplantibacillus plantarum N-1 improves autism-like behavior and gut microbiota in mouse.
⁶⁰Lactiplantibacillus plantarum ST-III-fermented milk improves autistic-like behaviors in valproic acid-induced autism spectrum disorder mice by altering gut microbiota.
⁶¹Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder.
⁶²Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms.
⁶³Bifidobacterium animalis subsp. lactis Probio-M8 alleviates abnormal behavior and regulates gut microbiota in a mouse model suffering from autism.
⁶⁴A synbiotic formulation of Lactobacillus reuteri and inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut-brain axis.
⁶⁵Oral Minocycline Therapy Improves Symptoms of Myalgic Encephalomyelitis, Especially in the Initial Disease Stage.
⁶⁶Could Minocycline Be a “Magic Bullet” for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
⁶⁷Long-term effect of cognitive behavioural therapy and doxycycline treatment for patients with Q fever fatigue syndrome: One-year follow-up of the Qure study.
⁶⁸Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.
⁶⁹Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
⁷⁰Azithromycin in chronic fatigue syndrome (CFS), an analysis of clinical data.
⁷¹Chronic fatigue syndrome post-COVID-19: triple-blind randomised clinical trial of Astragalus root extract.
⁷²[Post-COVID syndrome with fatigue and exercise intolerance: myalgic encephalomyelitis/chronic fatigue syndrome].
⁷³Neurovascular Dysregulation and Acute Exercise Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Placebo-Controlled Trial of Pyridostigmine.
⁷⁴Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives.
⁷⁵Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: an evidence-based approach to diagnosis and management by clinicians.
⁷⁶Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
⁷⁷Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia.
⁷⁸Effects of Hyperbaric Oxygen Therapy on Long COVID: A Systematic Review.
⁷⁹Reversible widespread brain (18)F-FDG PET hypometabolism in chronic fatigue syndrome treated by hyperbaric oxygen therapy.
⁸⁰[Fibromyalgia and myalgic encephalomyelitis: The oxygen clue].
⁸¹The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome.
⁸²Effects of Waon therapy on chronic fatigue syndrome: a pilot study.
⁸³Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) – a clinical audit.
⁸⁴[A new treatment: thermal therapy for chronic fatigue syndrome].
⁸⁵The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.
⁸⁶Clinical activity of folinic acid in patients with chronic fatigue syndrome.
⁸⁷Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
⁸⁸Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.
⁸⁹Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome.
⁹⁰News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments.
⁹¹Effects of Qiye Shen`an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life in Patients with Chronic Fatigue Syndrome.
⁹²B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
⁹³Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
⁹⁵Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review.
⁹⁶[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].
⁹⁷Intravenous magnesium loading in chronic fatigue syndrome.
⁹⁸Prospective observational study of treatments for unexplained chronic fatigue.
⁹⁹[Therapy of chronic fatigue syndrome].
¹⁰⁰Psychotropic treatment of chronic fatigue syndrome and related disorders.
¹⁰¹Chronic fatigue syndrome and liquorice.
¹⁰²Chronic fatigue syndrome and liquorice.
¹⁰³Liquorice and chronic fatigue syndrome.
¹⁰⁴High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome.
¹⁰⁵Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
¹⁰⁶Assessment of Bioautography and Spot Screening of TLC of Green Tea (Camellia) Plant Extracts as Antibacterial and Antioxidant Agents
¹⁰⁷GUT MICROBIOTA DYSBIOSIS IS LINKED TO HYPERTENSION
¹⁰⁸Modulation of the gut microbiota composition by rifaximin in non-constipated irritable bowel syndrome patients: a molecular approach
¹⁰⁹The Influence of Nonsteroidal Anti-Inflammatory Drugs on the Gut Microbiome
¹¹⁰Impact of probiotic supplements on microbiome diversity following antibiotic treatment of mice
¹¹¹Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men
¹¹²Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier
¹¹³Antibiotic use in childhood alters the gut microbiota and predisposes to overweight
¹¹⁴Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior
¹¹⁵Energy-dense diet triggers changes in gut microbiota, reorganization of gut-brain vagal communication and increases body fat accumulation
¹¹⁶Health benefit of vegetable/fruit juice-based diet: Role of microbiome