For updated information see Microbiome Prescription

Megasphaera elsdenii NCIMB 41125 is used as a probiotic with cattle

DataPunk.Net Data

ANTIBIOTIC RESISTANCE

• Tetracycline

PubMed Data

There are 400+ studies on PubMed.

Disease

• “We identified links between rosacea and several changes in gut microbiota: reduced abundance of Peptococcaceae family unknown genus, Methanobrevibacter (genus), Slackia (genus), Coprobacillus (genus), Citrobacter (genus), and Desulfovibrio (genus), and increased abundance of Acidaminococcus (genus), Megasphaera (genus), and Lactobacillales order unknown family unknown genus. ” [2017]
• ” Bifidobacterium, Megasphaera, Haemophilus and Streptococcus; and five genera enriched in infants with eczema: Escherichia/Shigella, Veillonella, Faecalibacterium, Lachnospiraceae incertae sedis ” [2016]

Diet

• “The levels of Selenomonas ruminantium, Anaerovibrio lipolytica, Ruminobacter amylophilus, Succinivibrio dextrinosolvens and Megasphaera elsdenii were increased by ginkgo extract supplementation, possibly contributing to the higher propionate production.” [2017]

Prebiotics

Probiotics

• “Dietary supplementation with B. subtilis resulted in increased (P < 0.05) cecal counts of Megasphaera elsdenii.” [2015]

Antibiotics

Bottom Line

Avoid

• Ginkgo
• Bacillus  subtilis

Take

For updated information see Microbiome Prescription

DataPunk.Net Data

INHIBITED BY

• Flaxseed [parent]

ENHANCED BY

• Proton-pump inhibitors (PPI)
• Partial Sleep Deprivation [parent]
• Navy bean (Cooked)

PubMed Data

There are 14+ studies on PubMed.

Disease

• ” morbidly obese insulin resistant group had a significant increase in the abundance of Firmicutes, Fusobacteria, Pseudomonaceae, Prevotellaceae, Fusobacteriaceae, Pseudomonas, Catenibacterium, Prevotella, Veillonella and Fusobacterium compared to the morbidly obese low insulin resistant group. ” [2016]
• “two genera were depleted among those with high versus low cardiovascular disease risk profile” [2016]
• “Brachybacterium, Catenibacterium, Enterobacteriaceae, Halomonadaceae, Moraxellaceae, Nesterenkonia, Polyangiaceae, Pseudomonadaceae, and Thiothrix families were markedly increased in patients with end-stage renal disease.” [2013]
• “in subjects with a history of  C. difficile associated diarrhea , the dominant species were either Catenibacterium (33.0%) or Ruminococcus (65.6%).” [2011]

Diet

Prebiotics

Probiotics

• “Ruminococcus, Catenibacterium, Tanneralla, Allstipes, etc.  appeared only in the Enterococcus faecium treatment group,” [2016]
• “We also observed a significant decreased in Catenibacterium communities with Saccharomyces boulardi” [2017]
• “30 days after the start of probiotics (BIO-THREE®), the peak of Enterococcus was not seen any more, and Clostridium, Ruminococcus, Eubacterium, Catenibacterium and Bacteroides began to be detected,” [2012]

Antibiotics

• “There was a reduction in the abundance of Blautia, Catenibacterium, Lactobacillus, and Faecalibacterium species and an increase in Butyrivibrio, Oscillospira and Ruminococcus after (a cocktail of) bacteriophage administration. ” [2017]

BottomLine

Avoid

• Enterococcus faecium
• BIO-THREE
• Partial Sleep Deprivation [parent]
• Navy bean (Cooked)
• Proton-pump inhibitors (PPI)

Take

• Saccharomyces boulardi
• Flaxseed

A reader informed me that he has just gotten his 4th ubiome done. This is especially interesting because he recorded his Health Score when each one was done — thus we may be able to see patterns between the microbiome and the health score.

The Raw data

A Narrative

• Best:
  • Firmicutes:Bacteroidetes ratio  2.1 (normal)
  • Overgrowth Orders: 1
  • Overgrowth Genus ( > 1.5): 6
• 2nd Best
  • Firmicutes:Bacteroidetes ratio  1.7 (19% below)
  • Overgrowth Orders: 3
  • Overgrowth Genus ( > 1.5): 7
• 3rd Best
  • Firmicutes:Bacteroidetes ratio  3.1 (47% above)
  • Overgrowth Orders: 3
  • Overgrowth Genus ( > 1.5): 8
• Worst
  • Firmicutes:Bacteroidetes ratio  1.3 (39% above)
  • Overgrowth Orders: 7
  • Overgrowth Genus ( > 1.5): 11

It looked like Clostridiales overgrowth was the start, as it grew it made a friendly environment for two more to join: Flavobacteriales, and Coriobacteriales. This allowed the Burkholderiales to get established (eventually pushing out Clostridiales which has dropped  to just 71% in the last uBiome).  Burkholderiales foster the growth of many other orders as a result with the result massive drop in health status.

In short, we see an ongoing battle between the various bacteria-cartels!

Deep dive into the current uBiome example

A fresh ubiome sample is something that should be used to modify diet, supplements as soon as possible. As we have seen above, there are ‘bacteria wars’ between bacteria cartels so we have a moving target!

• Sutterella: https://cfsremission.wordpress.com/2017/10/13/decreasing-sutterella-genus/
• Moryella: https://cfsremission.wordpress.com/2017/11/11/decreasing-moryella-genus/
• Bilophila:   https://cfsremission.wordpress.com/2017/10/14/decreasing-bilophila-genus/
• Phascolarctobacterium: https://cfsremission.wordpress.com/2017/11/12/decreasing-phascolarctobacterium-genus/
• Erysipelatoclostridium: https://cfsremission.wordpress.com/2017/11/14/decreasing-erysipelatoclostridium-genus/
• Collinsella: https://cfsremission.wordpress.com/2017/10/10/decreasing-collinsella-genus/
• Dorea :  https://cfsremission.wordpress.com/2017/10/18/reducing-dorea-genus/
• Parabacteroides: https://cfsremission.wordpress.com/2017/10/17/decreasing-parabacteroides-genus/
• Anaerostipes:   https://cfsremission.wordpress.com/2017/10/07/decreasing-anaerostipes-genus/
• Peptoclostridium: https://cfsremission.wordpress.com/2017/11/18/reducing-peptoclostridium-genus/
• Senegalemassilia: https://cfsremission.wordpress.com/2017/11/18/reducing-senegalemassilia-genus/

My immediate concern is Peptoclostridium, because it includes Peptoclostridium  difficile, the bacteria formerly known as Clostridium difficile!

Bottom Line Suggestions

The lists below are done by merging the lists from the deep dives linked above. Some items may encourage one genus and discourage another genus — those are removed (unless it seems that it strongly predominates on one). The impact on Lactobacillus, Bifidobacterium and E.Coli are intentionally ignored [See this post for the logic]. This is all based on applying logic to the results of studies — thus theoretical. This is an addition (not a replacement) to this overview post.

Avoid

• Amoxicillin-Clavulanate antibiotics
• Animal-based diet
• arabinoxylans
• Barley
• Berberine
• Bifidobacterium adolescentis
• Bifidobacterium longum.
• Bile
• BPA bottles
• Butyrate producing probiotics
• Canole Oil
• Chicory root
• Dairy
• Glucose foods (fructose [fruit sugar] appears to be fine)
• Helminth infections
• Isoniazid-
• Lactobacillus rhamnosus
• Lingonberries
• L-sorbose
• Milk-derived saturated fat
• Polydextrose
• Proton-pump inhibitors (PPI)
• Pyrazinamide
• Raspberries
• Rhubarb
• Rifampin-
• Saccharomyces boulardii
• Sleepless nights
• Soluble corn fiber
• Stress
• Walnuts
• Wheat Breads
• xylitol

Take

• Acarbose
• Capsaicin(chili peppers)
• Chicory
• Cranberry bean flour [parent]
• Flaxseed
• Fructooligosaccharides (FOS)
• Fumarate
• Galactooligosaccharides
• Galactooligosaccharides (GOS)
• Ketogenic diet
• Lactobacillus kefiri
• Lactobacillus paracasei
• Lactobacillus plantarum
• Lactobacillus reuteri
• l-glutamine
• Metronidazole antibiotics
• Mutaflor (E.Coli Nissle 1917)
• NSAIDs (see list here), I prefer aspirin as first choice.
• Oral Iron Supplements
• Polymannuronic acid
• Pomegranate
• Resveratrol (grape seed extract)
• Sleep
• Sodium chloride (Table Salt)
• Streptococcus probiotics
• Tea
• Vitamin D3
• β-glucan

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of CFS. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

For updated information see Microbiome Prescription

DataPunk.Net Data

ENHANCED BY

• Partial Sleep Deprivation [parent]

PubMed Data

There are 1+ studies on PubMed.

“This bacterium was isolated from the feces of a healthy Senegalese patient. It is a Gram-positive, anaerobic, indole-negative coccobacillus. ” [2013]

Disease

Diet

Prebiotics

Probiotics

Antibiotics

Bottom Line

Avoid

Take

• Lots of sleep!