Estácio Ferreira Ramos M.D. CEO, Cytomica®, Inc. | CTO, Microbio.World® | Hematology-

If you search ME/CFS + the name of a developed country, and then others, you will find that nations with high HDI are dealing with a bizarre, chameleonic, epidemic and endemic disease, a debilitating, systemic, very serious condition in many cases, and associated to suicides – a disease that has an incredible and revealing history, and that is expanding in cities almost all over the world, especially in the West.

Although it is said that it is still not enough, there are initiatives in these countries by numerous foundations, NGOs, universities, health systems, social movements, professionals, clinics and laboratories, patient associations, and company programs, aimed at raising awareness, funding, and combating the disease. Recently ME/CFS was discussed in the German parliament, and yesterday I read that it will be part of the UK medical curriculum. Fantastic. I have been studying the disease for 18 years.

The Netherlands, Belgium, and the Scandinavian countries are also especially victimized by ME/CFS and similarly develop medical education, awareness, treatment, and prevention programs. In the highly evolved and cold Iceland, where epidemic outbreaks occurred, the disease was so prevalent that it acquired local names: neuromyasthenia, Akureyri’s disease, and later Iceland disease. In the United States, in 2008, ME/CFS was considered by the CDC as the most concerning public health problem in the country. In Canada, the prevalence is as high or greater than in the USA.

These are characteristics common to countries with a lot of ME/CFS, a high HDI, an abundance of industrialized (sterilized) food; and perhaps, very cold winters. In Oceania and Japan, the prevalence appears to be somewhat lower.

A map of ME/CFS epidemics published by Donald Acheson in 1959 already showed target countries; these have changed little, but the number of patients has exploded.

The maps in Chapter 15 of Pandemics Entangled© also lay bare this epidemiological aberration, and the website of the American Myalgic Encephalomyelitis and Chronic Fatigue Syndrome Society brings another outdated world map of ME/CFS that confirms what this text describes: ME/CFS is a disease of rich countries.

However, in developing nations the ME/CFS story is different. Let us see.

Search now ME/CFS + the name of a tropical developing country: you find nothing or almost nothing. In these countries, the disease is practically unknown, because, in fact, the number of people affected is relatively much smaller. But not just for that.

These numbers are repeated throughout Latin America, and most of Asia: ME/CFS in these regions is almost non-existent. In African nations, the prevalence is very low, with two exceptions: South Africa (where there is a high HDI and cold winters), and Nigeria, whose high prevalence of ME/CFS is attributed to endemic malaria; but which in my opinion is due more to the excessive or preventive use of antibiotics, due to the large number of infections of the water cycle.

Let’s consider Brazil, a continental country, with 215 million inhabitants, large metropolises, 546 thousand doctors, powerful advanced medicine, hospitals among the best on the planet, a gigantic public and universal health system, legal telemedicine, and 357 medical schools – the largest number of medical schools in the world. However, searching today (June 24, 2023) on Google using Chrome: ME/CFS + Brasil; I found only one paper from 2010 that mentions CFS, nothing else. No publication in the last thirteen years even mentions the acronym ME/CFS.

Using Microsoft’s Bing, I found only a brief discussion on a Forum (February 2021) outside of Brazil Brazil: ME/CFS in Brazil | Phoenix Rising ME/CFS Forums, which reported on the lack of awareness of the disease in the country; and revealed the launch of the country’s first website about the condition.

I participate in some groups of doctors; among 800 professionals, only six knew about the disease; two of them have the condition.

And why does this happen?

I understand there are four reasons:

1) The country’s medical culture ignores the existence of ME/CFS, setting up a classic example by Claude Bernard: the doctor does not know what he is looking for, and does not value what he finds;

2) many patients with ME/CFS are labeled as having fibromyalgia, and many others remain undiagnosed;

3) because there is much less disease; restricted to classes A|B, almost three women for every man; and …

4) due to prejudice from health professionals; resulting from lack of knowledge and the unresolved problem that each patient brings or represents; and that closes the vicious circle. Just to cite one example, months ago, a renowned cardiologist colleague confessed to me among friends and other colleagues: “I hate it when the patient says he has fibromyalgia! ”… And he added: “If I could avoid it, I wouldn’t even evaluate the patient.”

So it is. For fifteen years, in order to better identify and investigate 70 patients with ME/CFS, I had to see 201 patients whose main diagnosis was fibromyalgia; another 39 were diagnosed with Lyme, viral fatigue, chronic EBV, psychosis, etc. Only 20 had the initial diagnosis of ME/CFS, formulated by me.

ME/CFS is a disease of rich countries, yes; but not only of those. And don’t make the mistake of thinking that the number of ME/CFS victims in Brazil and other developing countries is negligible; in the most privileged parts of these countries thousands live under a high HDI; and similarly develop the condition and fill the most luxurious offices and the relatively new pain clinics.

Importantly, in early 2020, long before the coexistence of ME/CFS and Covid complications now known as Covid Longa was described, I foresaw what are now facts: that the incidence of ME/CFS would explode in the post-Covid world, and that sequelae or late effects of the coronavirus would add to, or confound with ME/CFS – that the pandemics would entangle.

Therefore, in mid-2020 I changed the title of the work to Outbreak 64®, and then created the new page on LinkedIn, starting Pandemics Entangled© the only editorial project on the platform, where I published the Foreword, and then the first chapters of a now completed book.

The results of the research, the experience with the patients, and data from the literature make it necessary to recognize that the fundamental etiogenic factor for ME/CFS is the hostile environmental disturbance that leads to the breakdown of the greater symbiosis; understanding the greater symbiosis as the complex and vital relationship that we need to maintain with the microbial world, and which, when broken, imposes burdens on homeostasis and leads to the state of disease.

There are many examples of our dependence on flora. Doctors are aware of the bleeding problem that stems from antibiotics. These drugs reduce the population of bacteria in the intestine that produce vitamin K, which is needed for clotting proteins. Without these bacteria, without this vitamin, we can bleed.

By way of illustration, in an elegant post by Elena Panzeri, the infographic below reveals 35 metabolites of the microbiome that participate in the development, function, and integrity of the human brain.

The list is another example of the vital principles that are provided by the microscopic creatures that surround us and that we carry along with us; whose scarcity, imbalance, or anomalous interaction in an inhospitable environment, leads to what we know as ME/CFS. It makes sense to assume that the same is true for all other organs and systems.

The paradox of a so-called incurable disease, which has a rate of 4% to 8% of spontaneous cures reinforces this conviction. These healings occur by re-establishing the great symbiosis – casual, deliberate, or professionally oriented.

Today I read an article in which the author advocates the need for caution in attempts to restore the microbiome in ME/CFS patients, with which I wholeheartedly agree; it is difficult. But I don’t agree with the viral illness that she advocates as the cause of illness.

The cause is the deprivation and destruction of beneficial microorganisms in the surroundings and in the lives of those affected. In other words, the cause is the victory of civilization in the stupid war imposed on the microorganisms on which we depend for life and health. Due to fear of infections, we resolved that we should destroy them all around us, malefic and benefic, in every way. The result is ME/CFS. Just do not see it who refuses to see.

I have already posted repeatedly here that, once installed, the ME/CFS is a heavy transatlantic that left its course carried away by a strong current; correcting its course is usually a slow, tiring, painful process.

What I call an antibiotic environment is an environment hostile to the microbiome of urban life, with a high standard of sanitation, excessive hygiene, chlorinated and fluoridated water, and reduced social contact. The antibiotic environment is in hospitals and in the lives of health professionals; it can start with surgical, aseptic birth, and expand into the lives of solitary people, small families, apartments without animals and plants; and in detergents and antiseptics in all their forms; in the excessive use of antibiotics and antifungals, deodorants, alcohol gel, mouthwashes; it is in fast food, and in sterile foods, mainly industrially processed ones, in the additives and agrochemicals added to those; in pasteurization, in UHT, in irradiated foods, in preserves, in canned goods.

There is an enormous amount of chemical and antibacterial substances in industrialized foods, and it is legitimate to believe that they damage our flora.

In human food, this friendly, green, ECO logo, with a natural, organic look, is the radura logo. It signals that your food has been irradiated.

Irradiation is the pasteurization of the 21st century.

Radiation does not remain in the product and theoretically irradiated food is not harmful; but the good it does is limited; it roasts the DNA of any form of life, it kills all fungi and bacteria; extends the validity and duration of products. Dairy products lose life (fermenters die), are plasticized, and get chemical flavorings for flavor; and the banana in the plastic wrapper lasts over a month on the shelf.

It is relevant information that ME/CFS does not exist in simple people, nor in the rural environment in Brazil.

The opposite of ME/CFS is life in the countryside, it’s in full houses, with real food, made by hands, with fresh ingredients. It is in the water of the rivers, in the garden and in the garden, in bare feet, in unprotected sex, on the beach, in craft beer, in wine, in domestic animals, in fresh milk, and in food fermented at home.

I have examples and testimonies of people who have been healed by lifestyle changes. The adoption of a probiotic lifestyle, which includes the consumption of various natural probiotics, gradually improves the clinical picture.

There is a video of the end of the pandemic, in which the famous Brazilian actor Lima Duarte recounts his childhood in which he would wake up with his father at dawn, to take the calf to the cow and be able to milk it. He says that it is the cow’s love for her calf that makes her release her milk; and prophesies that other pandemics will come because we are living wrong – that the cow’s love is missing in the milk from mechanical milking. And what is more serious, I add: cow and calf microbiomes are also missing, my dear.

ME/CFS is the apple of the eye of anyone who sells diagnoses and treatments, finances or carries out research, creates products, information, and technology to treat the symptoms of a so-called never-ending disease, which causes so much suffering – and which is also a vast and fertile ground for all kinds of quackery.

To avoid conflict of interest, all medical research work was pro bono. All patients were returned to the colleagues who referred them.

Source: https://www.linkedin.com/pulse/mecfs-pandemic-wealthy-est%C3%A1cio-ferreira-ramos-m-d-/

Estácio Ferreira Ramos M.D. CEO, Cytomica®, Inc. | CTO, Microbio.World® | Hematology-

There is a giant sphinx of evidence showing that restricted access to the planet’s microbiome is the fundamental etiogenic factor of ME/CFS, but most scientists refuse to face this veritable monument of information.

Let us see a few things.

There are 63 recognized epidemics of the disease, 31 of which occurred in hospitals, just affecting health professionals. The first, in 1934, hit all 198 nurses and doctors at the Los Angeles County Hospital, but curiously, none of the patients admitted to the institution. Until today, the predilection of the disease for health professionals is an undisputed fact; why is that? …

The fact is, health professionals spend most of their lives in aseptic environments, where access to the natural microbiome is blocked. Mechanical barriers (masks, gloves, caps, sterile clothing, disposable aprons, safety glasses, shoe covers), chemicals (frequent washing of hands with detergents, abusive and continuous use of degerming agents (alcohol, chlorhexidine, iodine, hypochlorite, etc.), and even cultural behaviors block the access to beneficial microorganisms. In 2010, I saw in London the recommendation to avoid kisses on the cheeks and handshakes on hospital premises.

England is one of the nations with the highest incidence of ME/CFS, and in which a culture of greater distance and respect for personal space prevails. With the COVID-19 pandemic, this culture has been intensified throughout the world, a fact that made me foresee the global increase of ME/CFS, and change the title of my work, from Outbreak 64© to Pandemics Entangled©.

Taking the first epidemic of ME/CFS as a paradigm, in 1934 Pasteur had already demonstrated the bacterial origin of the infections, but penicillin was still not available, and the hospital had many infections; hygiene norms were therefore neurotic. In addition, foods were also strictly sterile, and there was a boom in spam and canned foods, considered safer because they were sterile (the occurrence of botulism in the first canned foods led the industry to intensify food sterilization systems in cans).

DeMeirleir et.al. advocate that the ingestion of metals by people living with dysbiosis triggers or aggravates ME/CFS, and the welds of the first cans contaminated the food they contained with toxic metals.

The other epidemics victimized human groups in relatively isolated or restricted coexistence: convents, military bases, schools, a ship, industries, groups of athletes, having in common few interpersonal contacts, and cafeterias with carefully sterile food, aiming at the prevention of food infections. I believe that cold winters also favor the emergence of disease, by limiting the expansion of the natural microbiome.

Read under this light, the long history of ME/CFS and fibromyalgia, thoughtfully summarized in Chapter 9 of Pandemics Entangled©, makes this truth much easier to understand and accept.

Besides, considering the Epidemiology of ME/CFS, summarized in Chapter 15, it solidifies the understanding that the greater symbiosis breakdown leads to this confusing spectrum of diseases.

Adding to this set of evidence is the fact that isolated cases of these diseases began to affect middle-aged upper-middle-class women: more acculturated mothers and grandmothers, with access to better sanitation, and higher hygienic standards; determined to make food safer (meaning sterile) for their children and grandchildren.

I am not refuting here any of the hundreds, perhaps thousands, of research that demonstrates countless pathophysiological mechanisms involved in ME/CFS (although many are refutable); I just focus on the essential condition that leads to the development of the disease: the war imposed by civilization on the microbiome of the blue planet.

I am sure that in the near future a good epidemiologist with access to the internet, and with some software or calculator, will confirm my theory; which supports and has been strengthened by the research I have carried out over fifteen years.

In addition, I envision the moment when artificial intelligence resources and/or a broader meta-analysis will seal this knowledge.

This sphinx will not devour me. Neither will those willing to accept the intuitive knowledge that deciphers it.

The worst blind is the one who refuses to see.

Source: https://www.linkedin.com/pulse/mecfs-sphinx-microbiome-est%C3%A1cio-ferreira-ramos-m-d-/

Estácio Ferreira Ramos M.D. CEO, Cytomica®, Inc. | CTO, Microbio.World® | Hematology-Oncology

Se você pesquisar ME/CFS + o nome de um país desenvolvido, e depois outros, você descobrirá que as nações com alto IDH estão lidando com uma doença bizarra, camaleônica, epidêmica e endêmica, debilitante, sistêmica, gravíssima em muitos casos, e associada a suicídios – uma doença que tem uma história incrível e reveladora, e que se expande nas cidades de quase todo o mundo, em especial no Ocidente.

Embora se diga que ainda é muito pouco, há nesses países iniciativas de numerosas fundações, ONGs, universidades, sistemas de saúde, movimentos sociais, profissionais, de clínicas e laboratórios, associações de pacientes, e programas de empresas, voltados à conscientização e ao combate da doença. Recentemente ME/CFS foi discutida no parlamento alemão, e ontem li que fará parte do currículo médico do Reino Unido. Fantástico. Há 18 anos eu estudo a doença.

Holanda, Bélgica e os países da Escandinávia são também especialmente vitimados por ME/CFS, e similarmente desenvolvem programas de educação médica, conscientização, tratamento e prevenção. Na evoluída e gelada Islândia, onde ocorreram surtos epidêmicos, a doença é de tal prevalência que adquiriu designações locais: neuromiastenia, doença de Akureyri, depois doença da Islândia. Nos Estados Unidos, em 2008, ME/CFS foi considerada pelo CDC como o problema de saúde pública mais preocupante no país. No Canadá a prevalência é tão alta ou maior que a dos USA.

São características comuns aos países com muita ME/CFS, um elevado IDH, abundância de alimentos industrializados (esterilizados); e talvez, invernos muito frios. Na Oceania e no Japão a prevalência parece ser um pouco menor.

Um mapa das epidemias de ME/CFS publicado por Donald Acheson em 1959 já mostrava os países-alvo; esses pouco mudaram, o número de doentes é que explodiu.

Os mapas no Capítulo 15 de Pandemics Entangled© também desnudam essa aberração epidemiológica; e no site da American Myalgic Encephalomyelitis and Chronic Fatigue Syndrome Society, um outro mapa mundi desatualizado da ME/CFS já confirmava o que este texto descreve: ME/CFS é doença de países ricos.

Entretanto, nas nações em desenvolvimento a história da ME/CFS é outra. Vamos ver?

Pesquise agora ME/CFS + o nome de um país tropical em desenvolvimento: você não encontra nada, ou quase nada. Nesses países a doença é praticamente desconhecida, porque de fato, o número de acometidos é relativamente bem menor. Mas não só por isso.

Esses números se repetem em toda a América Latina, e na maior parte da Ásia: ME/CFS nessas regiões quase inexiste. Nas nações da África, a prevalência é baixíssima, com duas exceções: a África do Sul (onde há IDH alto e invernos frios), e a Nigéria, cuja alta prevalência de ME/CFS é atribuída a malária endêmica; mas que no meu entender deve-se mais ao uso excessivo ou preventivo de antibióticos em razão de grande número de infecções do ciclo da água.

Vamos considerar o Brasil, um país continental, com 215 milhões de habitantes, grandes metrópoles, 546 mil médicos, medicina pujante, hospitais dentre os melhores do planeta, um gigantesco sistema público e universal de saúde, e 357 escolas médicas, o maior número de escolas de medicina no mundo. Não obstante, pesquisando hoje (24 de junho de 2023) no Google usando o Chrome: ME/CFS + Brasil; encontrei apenas um trabalho de 2010 que menciona CFS, nada mais. Nenhuma publicação nos últimos treze anos que sequer mencione a sigla ME/CFS.

Usando o Bing da Microsoft, encontrei apenas uma breve discussão em um Fórum (Fevereiro de 2021) fora do Brasil Brazil: ME/CFS in Brazil | Phoenix Rising ME/CFS Forums., que informava sobre o desconhecimento da enfermidade no país; e revelava o lançamento do primeiro site no país sobre a doença.

Participo de alguns grupos de médicos; dentre 800 profissionais, apenas seis conheciam a doença; dois deles portadores da condição.

E porque isto ocorre?

Entendo que há quatro motivos:

1) A cultura médica do país ignora a existência de ME/CFS, configurando um exemplo clássico de Claude Bernard: o médico não sabe o que procura, e não valoriza o que encontra;

2) muitos pacientes com ME/CFS são rotulados como portadores de fibromialgia, e outros tantos ficam sem diagnóstico;

3) porque há muito menos doença mesmo; restrita às classes A|B, quase três mulheres para cada homem; e …

4) por preconceito dos profissionais de saúde; decorrente de desconhecimento e do problema sem solução que cada paciente traz ou representa; e que fecha o círculo vicioso. Só para citar um exemplo, meses atrás, um renomado colega cardiologista me confessou entre amigos e outros colegas: “eu odeio quando o paciente diz que tem fibromialgia! ”… E completou: “se eu pudesse evitar, eu nem atenderia. ”

Assim é. Por quinze anos, para identificar e conseguir investigar melhor 70 pacientes com ME/CFS, precisei atender em consultório 201 pacientes cujo principal diagnóstico era fibromialgia; outros 39 foram diagnosticados Lyme, fadiga viral, EBV crônico, psicose, etc.  Apenas 20 tiveram o diagnóstico inicial de ME/CFS, formulado por mim.

ME/CFS é doença de países ricos, sim; mas não só deles. E não cometa o erro de achar que é desprezível o número de vítimas da ME/CFS no Brasil e nos demais países em desenvolvimento; nas parcelas mais privilegiadas nesses países milhares vivem sob um IDH elevado; e similarmente desenvolvem a condição e enchem os consultórios mais luxuosos, e as relativamente novas clínicas da dor.

Importante, no início de 2020, muito antes de ser descrita a coexistência de ME/CFS e complicações da Covid hoje conhecidas por Covid Longa, antevi o que hoje são fatos: que a incidência de ME/CFS explodiria no mundo pós-Covid, e que as sequelas ou efeitos tardios do coronavírus se somariam ou confundiriam com ME/CFS – que as pandemias se entrelaçariam.

Por isso, em meados de 2020 modifiquei o título do trabalho que seria Outbreak 64®, e depois criei a nova página no LinkedIn, dando início a Pandemics Entangled© o único projeto editorial na plataforma, onde publiquei o Prefácio, e a seguir os primeiros capítulos do um livro agora concluído.

Os resultados da pesquisa, a vivência com os pacientes, e os dados da literatura impõem reconhecer que o fator etiogênico fundamental à ME/CFS é o distúrbio ambiental hostil que leva à quebra da grande simbiose; entendida a grande simbiose como o relacionamento complexo e vital que precisamos manter com o mundo microbiano, e que rompido impõe gravames à homeostasia e leva ao estado de doença.

São muitos os exemplos da nossa dependência da flora. Os médicos conhecem o problema hemorrágico que decorre de antibióticos. Esses medicamentos reduzem no intestino a população de bactérias que produz a vitamina K, necessária às proteínas da coagulação. Sem essas bactérias, sem essa vitamina, podemos apresentar sangramentos.

A título ilustrativo, em elegante post de Elena Panzeri, o infográfico abaixo revela 35 metabólitos do microbioma que participam do desenvolvimento, da função e da integridade do cérebro humano.

A lista é outro exemplo dos princípios vitais que são fornecidos pelas microscópicas criaturas que nos cercam e que levamos conosco; cuja escassez, desequilíbrio, ou interação anômala em um ambiente inóspito, leva ao que conhecemos por ME/CFS. Faz sentido supor que o mesmo ocorre para todos os outros órgãos e sistemas.

O paradoxo de uma doença dita incurável, mas que apresenta um índice de 4% a 8% de curas espontâneas reforça essa convicção. Essas curas ocorrem pelo restabelecimento da grande simbiose – casual, deliberado ou profissionalmente orientado.

Hoje li um artigo em que a autora advoga a necessidade de cuidado nas tentativas de restaurar o microbioma nos pacientes de ME/CFS, com o que concordo plenamente; é difícil. Mas não concordo com a doença viral que ela advoga ser a causa da doença.

A causa é a privação e a destruição dos microrganismos benéficos no entorno e na vida dos acometidos. Dito de outra forma, a causa é a vitória da civilização na estúpida guerra imposta aos microrganismos dos quais dependemos para viver e ter saúde. Por medo das infecções, resolvemos que deveríamos destruí-los a todos, maléficos e benéficos, de todas as formas. O resultado é ME/CFS. Só não vê quem não quer.

Já postei repetidamente aqui, que uma vez instalada, ME/CFS é um transatlântico pesado que saiu da sua rota levado por uma corrente forte; corrigir o seu curso é geralmente um processo lento, cansativo, sofrido.

O que chamo de ambiente antibiótico é o ambiente hostil ao microbioma da vida urbana, com elevado padrão de saneamento, higiene excessiva, água clorada e fluoretada, e reduzidos contatos sociais. O ambiente antibiótico está nos hospitais e na vida dos profissionais de saúde; pode ter início no nascimento cirúrgico, asséptico, e se expandir na vida dos solitários, das pequenas famílias, nos apartamentos sem animais e plantas; e nos detergentes e antissépticos em todas as suas formas, no uso excessivo de antibióticos e antifúngicos, de desodorantes e desodorizantes, de álcool-gel, de antissépticos bucais; está no fast-food, e nos alimentos estéreis, principalmente os industrialmente processados; nos aditivos e agroquímicos  adicionados; na pasteurização, no UHT, nos alimentos irradiados, nas conservas, nos enlatados.

Há uma quantidade enorme de substâncias químicas e antibacterianos nos alimentos industrializados, sendo lícito crer que danificam a nossa flora.

No alimento humano, esse logotipo simpático, verde, ECO, com cara de natural, de orgânico, é o radura logo. Ele sinaliza que a sua comida foi irradiada.

A irradiação é a pasteurização do século 21.

A radiação não fica no produto e teoricamente o alimento irradiado não faz mal; mas o bem que faz é limitado; ela torra o DNA de qualquer forma de vida, mata todos os fungos e bactérias; estende a validade e a duração dos produtos. Laticínios perdem vida (morrem os fermentadores), são plastificados e ganham aromatizantes para ter sabor; e a banana no invólucro plástico dura mais de um mês na prateleira.

É relevante a informação de que ME/CFS não existe no povo simples, nem no ambiente rural no Brasil.

O oposto de ME/CFS é a vida no campo, está nas casas cheias, com comida de verdade, feita por mãos, com ingredientes frescos. Está na água dos rios, na horta e no jardim, nos pés descalços, no sexo desprotegido, na praia, na cerveja artesanal, no vinho, nos animais domésticos, no leite fresco, no alimento fermentado em casa. Tenho exemplos e testemunhos de pessoas que ficaram curadas por mudanças no estilo de vida. A adoção de um estilo probiótico de vida, o que inclui o consumo de variados probióticos naturais, gradualmente produz melhora do quadro clínico.

Há um vídeo do fim da pandemia, em que o famoso ator brasileiro Lima Duarte narra a sua infância em que acordava com o pai nas madrugadas, para levar o bezerro ao pé da vaca e conseguir ordenhá-la. Ele diz que é o amor da vaca pelo bezerro que a faz liberar o leite; e profetiza que outras pandemias virão, porque estamos vivendo errado – que falta o amor da vaca no leite da ordenha mecânica. E o que é mais grave, eu acrescento: falta também o microbioma dela e do bezerro, meu caro.

ME/CFS é a menina dos olhos de quem vende diagnósticos e tratamentos, financia ou realiza pesquisas, cria produtos, informação, e tecnologia para tratar os sintomas de uma doença dita sem fim, que tanto sofrimento produz – e que também é terreno vasto e fértil para todo tipo de charlatanismo.

Para impedir conflito de interesse, todo o trabalho médico da pesquisa foi pro bono. Todos os pacientes foram retornados aos colegas que os encaminharam.

Source: https://www.linkedin.com/pulse/mecfs-pandemia-dos-ricos-est%C3%A1cio-ferreira-ramos-m-d-/

Estácio Ferreira Ramos M.D. CEO, Cytomica®, Inc. | CTO, Microbio.World® | Hematology-

July 24, 2023

In several moments of medicine, the cure was discovered before the cause of the disease was known. Hippocrates treated the anemia of women and children by giving them blackened water from a vase where he left a sword immersed for a few days: iron oxide and ferrous sulfate, the same active principles of medicines that we still use today to treat sideropenia.

In 1747, through the first clinical trial in history, James Lind discovered that citrus fruits and spruce beer cured scurvy, a terrible disease that killed thousands of English sailors, two centuries before the discovery of vitamin C, whose history is a special chapter in medicine. There are many other examples.

In the last half-century, many new epidemic and endemic diseases of insidious behavior have increased and continue to grow in the world, especially in the most civilized regions of the planet; and the sum of evidence points to the depletion and breakdown of the symbiosis with the microbiome as the main factor associated with these many conditions.

The fact is, as we barely understand how it operates or how we actually interact with the microbiota of the planet; and its composition is so vast, and the interactions so complex that we cannot yet speak of causalities, but only of associations. And there are so many associations, and the spectrum of clinical conditions is so varied, that there is no way to escape the recognition that the breakdown of what I have called the greater symbiosis is indeed the cause of this variety of ills, which are even intertwined.

For example, through the extensive research described in Pandemics Entangled©, I have disclosed that the fundamental etiogenic factor in the ME/CFS/Fibromyalgia complex is the distancing or destruction that civilization imposes on the planet’s microbiome around and inside us, and the consequences of this go further.

Thus, science associates the altered microbiome with conditions such as allergies, sensitivity to multiple substances, ulcerative colitis, necrotizing enteritis of newborns, inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, diabetes, atopy and asthma, cardiometabolic diseases, and cancer. Plus those strange conditions that I didn’t see in medical school, but are now part of my daily life: epidemic gastroesophageal reflux disease, pandemic h. pylori and gastric disease, non-celiac gluten intolerance, endemic obesity, panic disorder, irritable bowel syndrome, autism, ADHD, anxiety, depression suicide complex. The list is much longer, and growing.

If we consider the history of ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome/fibromyalgia) we find that those are conditions of people and human groups that, in different ways and always for reasons related to civilization, have distanced themselves from nature, from the symbiosis with the microcosm. And this led to some very strange things, like the Gulf War Syndrome – in which ailments in veterans caused by factors directly related to the war entangle with (a disease identical to) ME/CFS that afflicted them, but also the non-military personnel who were in the war, such as administrative staff and members of the press. And more strangely, many of their family members – people who have never been to the Middle East.

Going back to the first paragraph, the fundamental etiogenic factor for scurvy in sailors was the prolonged time at sea, more specifically the prolonged distance from land, where there was a vital principle that did not exist in the sea: vitamin C.

Seen from this perspective, civilized humans are now experiencing A NEW SCURVY, a set of diseases with a common etiogenic factor: the distancing of the natural microbiome; and this time not from land, but from Earth.

Again, the letter C represents a huge contingent of the affected, because according to the CDC it is in the class C of the United States that ME/CFS expands most in the country. It is in microbiome environments similar to that in which the North American class C lives that the disease expands in the world. The environment with sanitation, hygiene, and sterile food that only people from classes A-B reach in emerging countries. The same environment veterans were in during the Gulf War – and outside of it, their families.

In the environment of the 2001 Gulf War, military vehicles represented the British ships of the 17th and 18th centuries. Nowadays, the fear of water-cycle diseases has given rise to a portentous capacity to produce sterile military rations and drinking water, totally deprived of the microbiome; and which represents the new scurvy, the diet of those English soldiers in their old ships, deprived of a vital principle from which they should never split.

In the recent past, when a few hundred proteins and antibodies made it difficult to understand the HLA System, it took the intervention of a mathematician to unravel the complexity of that system, which today involves thousands of proteins.

However, our relationship with the microbiome is infinitely more complex. And although it has been easy to understand how a single kind of microorganism causes a disease (such as trypanosomiasis), or how two types of pathogens cause a disease (Paul-Vincent’s angina, and long-term salmonellosis); or how a single type of microorganism causes more than one disease (such as VZV causing chickenpox and herpes zoster, or EBV that determines mononucleosis and Burkitt’s lymphoma), understanding our interactions with millions of microorganisms that interact with each other and participate in the integrity and function of all living forms will indeed be an almost impossible, spectacular feat.

However, everything leads us to believe that meta-analyses evaluated by artificial intelligence under quantum computing, will soon be the power capable of showing the homo sapiens the fascinating dance of the micro-world with all living things is really like.

Those who live will see.

Source: https://www.linkedin.com/pulse/microbiome-new-scurvy-est%C3%A1cio-ferreira-ramos-m-d-/

Attached you will find a PowerPoint PDF with a YouTube presentation. The target audience is
Medical Practitioners treating ME/CFS and Long Covid.

Parallels between Hans Christian Andersen’s “The Emperor’s New Clothes” and the certainty of correct identification of bacteria often expressed by many microbiome researchers should be noted. “Andersen altered the source tale to direct the focus on courtly [academic] pride and intellectual vanity “

A detailed walk through targeted for Medical Practitioners on using the Microbiome to treat Long COVID and ME/CFS. New findings on strong associations (P less than 0.001) derived from the microbiome to these conditions. Discussion of how these finding can lead to treatment suggestions on an individual basis (instead of generic suggestions). Associations listed in full at:

• Long COVID: https://microbiomeprescription.com/sa…
• and for ME/CFS https://microbiomeprescription.com/sa…
• Associated Links:
  • https://cfsremission.com
  • https://microbiomeprescription.com
  • https://blog.microbiomeprescription.com

https://www.youtube.com/watch?v=8uG2z61rDcQ

Bottom Line

• Microbiome tests are not as precise as marketed. Tests have almost zero agreement with each other.
• Using test data with data from Kyoto Encyclopedia of Genes and Genomes produces extremely strong consistent associations to the absence (usually) or surplus of specific compounds across three different types of microbiome tests
• Working with this data quickly becomes very complex and require advance operations research techniques.
• To date, the results of this complex model has been in agreement with the literature (cross-validation), been show on individuals to objectively improve the microbiome with significant subjective improvement.