Autoimmune and Vitamin 1,25D

I thought that I should put together a collection on conditions that have been documented to have a high Vitamin 1,25D result(Calcitriol) when tested.

  • ” Results showed a strong positive association between these autoimmune conditions[ multiple sclerosis, lupus, psoriasis, osteoporosis, osteoarthritis, metabolic syndrome, fibromyalgia and chronic fatigue syndrome] and levels of 1,25-D >110 pmol/L. However, there was little association with vitamin D deficiency or the other inflammatory markers, meaning that the results challenge the assumption that serum levels of 25-D are a sensitive measure of the autoimmune disease state.” [2009]
  • “In granulomatous disease such as lymphoproliferative disorders, sarcoidosis, tuberculosis, and inflammatory bowel disease,”[emedicine]
  • “postural orthostatic tachycardia syndrome” – remission with calcitriol treatment [2012]

General Vitamin D level and symptoms

  • “A significant negative correlation between vitamin D level and widespread pain index was found.”[2012]
  • ” improvement became more significant when their blood level of 25(OH) D exceeded 50 ng/ mL.”[2011]
  • ” a positive association of vitamin D deficiency with a variety of nonspecific bone pain, particularly in women” [2010]
  • “Musculoskeletal pain is associated with very low levels of vitamin D in men” [2010]
  • “Resolution of hypersomnia following identification and treatment of vitamin d deficiency.” [2010]
  • “Vitamin D deficiency is a major risk factor for central nervous system (CNS) demyelinating diseases including multiple sclerosis (MS)” [2012]
  • “This study demonstrates for the first time a direct antiviral effect of vitamin D in an in vitro infectious virus production system.”[2011]
  • “vitamin D can suppress intracellular growth of M tuberculosis in vitro. Vitamin D also induced the expression of cathelicidin, which is involved in the first line of defense in TB patients” [2011]
  • “Vitamin D(3) skews cytokine responses toward an antiinflammatory profile,.. Candida albican” [2011]
  • Interesting that Epstain-Barr interfers with Vitamin D actions!!!! [2010]

For general information on Vitamin D and autoimnmune disease:

  • Studies have shown evidences of 1,25(OH)D in inhibiting disease induction in autoimmune encephalomyelitis, thyroiditis, type-1 diabetes mellitus, inflammatory bowel disease (IBD), systemic lupus  erythematosus, and collagen-induced arthritis and Lyme  arthritis, as reported by Hayes et al and Adorini et al.  Vitamin D deciency could accelerate the occurrence of autoimmune encephalomyelitis” [2007]