A recent comment stated “I had an allergic reaction to both CoQ10 (of which is listed as a “core” on this blog) and SAM-E – both of which are known to be required for the synthesis of ATP production.” I decided to do a little digging into this area.
CoQ10 – The literature
- We know that CoQ10 levels are lower with bronchial asthma ,   and with food intolerance and allergies 
- We also find that some bacteria can impact CoQ10  and that different bacteria produces it  
SAMe (Ademetionine)- The literature
The wikipedia article is an interesting read but has no reports of allergies. PubMed searches turned up similar findings as above, including production by bacteria.
We can similarly go on to other allergies, such as peanuts which had had an exponential growth as well as autoimmune. There is much speculation as to the cause.
My own speculation is that there has been an alteration of the microbiome from changes in food and that the root cause if this microbiome shift.
Inferential evidence come from some recent work:
- Mouth Microbes Influenced by Ethnicity “a machine-learning classifier was able to reliably identify a person’s ethnicity based on their subgingival microbes.”
- Black children have higher incidence in same urban areas than hispanic and other races  
- Arabs and Jews in Israel have different allergy profiles 
Our microbiome (including mouth) appears to have evolved with our traditional (ethnic) food and been passed along by such items as children sticking their fingers in their parent mouths. When this healthy population is subject to a different food supply (change of diet), then the microbiome shifts because there is an abundance of food that one uses, and a decrease in the food another one needs. A good population goes bad.
How to treat? Two experiments would be interesting to see if they impact allergies, especially peanut allergies,
- The oral probiotics:
- Fecal transplants or the new proposed pill version
The chemicals producing the allergic reaction may well be a result of chemicals released by the microbiome when exposed to these foods or supplements.