I stumbled across magnolia bark while looking for adaptogens.
Magnolia (Magnolia officinalis) is a medicinal plants commonly used as traditional remedies for reducing stress and anxiety. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects[ ] found that it significantly lower salivary cortisol . It is also a relatively strong anti-inflammatory Identification of Magnolia officinalis L. bark extract as the most potent anti-inflammatory of four plant extracts. Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression. confirmed its antidepressant-like effect.
Part of it’s mechanism is described in Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells and helps with cognitive damage Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction  as well as helping memory Ethanol extract of Magnolia officinalis prevents lipopolysaccharide-induced memory deficiency via its antineuroinflammatory and antiamyloidogenic effects.. Of special interest is its positive impact on memory Alzheimer’ (because some CFS SPECT scans appear similar to early Alzheimer) A Comparison between Extract Products of Magnolia officinalis on Memory Impairment and Amyloidogenesis in a Transgenic Mouse Model of Alzheimer’s Disease
For those with sleep disturbance, Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.
It’s impact on gut bacteria is less well known, however it does appear to have impact on oral bacteria according to Effect of a sugar-free chewing gum containing magnolia bark extract on different variables related to caries and gingivitis: a randomized controlled intervention trial. and Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor, Antimicrobial activity of magnolol and honokiol against periodontopathic microorganisms[1998-.. As well as some bacteria, Antimicrobial effect of Magnolia officinalis extract against Staphylococcus aureus. as well Antifungal activity of magnolol and honokiol
Bottom line: This is definitely an excellent candidate supplement for CFS, especially when taken immediately after dinner as a potential assistance to sleep disturbances.