Where to start…

As a result of some comments on another post, I realized that there appears to be a logical sequence for some of the supplements and probiotics. I suspect that this may be a good first sequence for many people because it should improve symptoms within a month.

  1. Magnesium deficiency is common with CFS patients. A 2012 study revealed that one bacteria is significant for the release of magnesium from food: Bifidobacterium :   http://www.ncbi.nlm.nih.gov/pubmed/22047159.
    1. This agrees with studies finding that Bifidobacterium are low in CFS patients.
  2. Low Magnesium levels inhibits the absorption of two items where higher levels have been found to have less symptoms:
    1. Vitamin D3
    2. Glutamine
  3. Magnesium is needed by some Lactobacillus species according to http://www.ncbi.nlm.nih.gov/pubmed/23082775 [2013]
    1. Thus low magnesium levels contribute to the low Lactobacillus levels seen in CFS patients.
    2. L.Reuteri is dependent on magnesium levels  — so low or no B12 production
      1. Enhancement of alpha- and beta-galactosidase activity in Lactobacillus reuteri by different metal ions. [2010]

This suggests that taking a magnesium supplement (like Magnesium Malate), eating magnesium rich food, and taking a pure  Bifidobacterium probiotics for the first 1-2 weeks, followed by adequate Vitamin D3 (15000 IU?) and Glutamine should reduce symptoms in 4 to 6 weeks.

  • NOTE: Align is a single strain Bifidobacterium that has been shown to put IBS into remission.  I found other pure Bifidobacterium at Walgreen’s — they are often label as digestive probiotics, for example Ultimate Flora RTS – Colon Care Probiotic which has six different ones and no Lactobacillus! 🙂   (
    • Bifidobacteria species.
    • Bifidobacterium lactis (A)
    • Bifidobacterium lactis (B)
    • Bifidobacterium bifidum
    • Bifidobacterium breve
    • Bifidobacterium lactis (C)
    • Bifidobacterium longum)
    • These are different then the Bifidobacterium infantis in Align. So there are seven species at least available.
  • Remember: The more species that you take the better your odds are finding one that “clicks with your DNA and takes up residence!” and “takes an attitude to the CFS causing cartel of bacteria”
  • “Bifidobacteria, naturally present in the dominant colonic microbiota, represent up to 25% of the cultivable faecal bacteria” (http://www.ncbi.nlm.nih.gov/pubmed/16167966 2005)…. reminder: there are myths about Lactobacillus being the dominant one… it’s false. Futhermore, L.Reuteri is the dominant one of all Lactobacillus in healthy mammals (including humans) — not L.acidophilus which just flows thru your bowels (and does NOT take up residence)!

This is all theoretical.  I do know that I was taking a lot of Magnesium Malate during my second onset to moderate symptoms (and it worked) as well as 20,000 IU of vitamin D3.

To put it together as a picture:


References of interest: