Psoriasis,CFS and the microbiome

One of the interesting side effects of addressing a dysfunctional microbiome was the major reduction (almost disappearance) of my prior psoriasis. This makes sense because the level of inflammatory chemicals in the body would drop which would affect all aspects of the body.

Of course the question arises — is there any PubMed studies that could back this observation?

” recent research has identified a group of conditions probably resulting from dysbiosis, or alternatively referred to as originating from a misrecognition or aberrant response to the normal microbiota, including inflammatory bowel disease (IBD), psoriasis (PS), bacterial vaginosis (BV) and periodontal diseases (PD) (2326). These four diseases seem to cluster together from an epidemiological, pathogenic, genetic and microbial standpoint, with similarities between them being recently reported (2736).” [2014]

This article goes on with:

Over 50 years ago, it was noted that two thirds of patients with the variant guttate psoriasis (GP) had a preceding sore throat and serological evidence of a streptococcal infection (59). This was then confirmed by the isolation of beta haemolytic streptococci [BHS] from the throats of patients with GP (60). Furthermore, guttate flares in chronic plaque PS are associated with streptococcal pharyngitis (61). Microbiological analysis of psoriatic skin report conflicting evidence on types of bacteria associated with the lesions: 16S rRNA gene analysis using swabbing of the skin to recover bacteria, has revealed differences in bacterial colonisation compared to healthy skin, with an increase in Firmicutes and a decrease in Actinobacteria.”

Another article [2014] states “we hypothesize that common immune-mediated inflammatory pathways seen in the “skin-joint-gut axis” in psoriatic arthritis are induced or at least mediated by the microbiome

Now for actual on human studies with patients with psoriasis [2013]:
“In conclusion, oral administration of a single microbial agent, B. infantis 35624, was sufficient to reduce systemic inflammatory biomarkers in both gastrointestinal and extra-intestinal inflammatory disorders. ” This study included 26 patients with psoriasis.  This probiotic (commonly sold as Align) happens to be one of those that I took.

2019 Study

A reader forwarded me this new study:

Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study [2019]

The relationship between psoriasis and the subsequent risk of CFS was estimated through Cox proportional hazards regression analysis, with the incidence density rates being 2.27 and 3.58 per 1000 person-years among the non-psoriasis and psoriasis populations, respectively (adjusted hazard ratio [HR] = 1.48, with 95% confidence interval [CI] 1.07–2.06). In the stratified analysis, the psoriasis group were consistently associated with a higher risk of CFS in male sex (HR = 2.05, 95% CI 1.31–3.20) and age group of ≥ 60 years old (HR = 2.32, 95% CI 1.33–4.06). In addition, we discovered that the significantly increased risk of CFS among psoriasis patients is attenuated after they receive phototherapy and/or immunomodulatory drugs.

Conclusion: my improvement is psoriasis was indeed due to the probiotics!