Bacteria and Memory Issues

Readers know that my own experience was having a SPECT scan that was read as early Alzheimer’s Disease during my last flare. Remission of CFS resulted from aggressively altering bacteria. A reader just posted me a new research articles that rings true to me — because CFS has been associated with walking pneumonia in me for almost 40 years (before CFS was known). This was likely Chlamydophila pneumoniae in my case. 

J Alzheimers Dis. 2014 Sep 2. [Epub ahead of print]

Bacterial Infection and Alzheimer’s Disease: A Meta-Analysis.

Abstract

The possibility of an infectious etiology for Alzheimer’s disease (AD) has been repeatedly postulated over the past three decades. We provide the first meta-analysis to address the relationship between bacterial infection and AD. Studies examining the association between AD and spirochetal bacteria or Chlamydophila pneumoniae (Cpn) were identified through a systematic search of the databases MEDLINE, EMBASE, PubMed, and Google Scholar. Data combined from 25 relevant, primarily case-control studies demonstrated a statistically significant association between AD and detectable evidence of infection of either bacterial group. We found over a ten-fold increased occurrence of AD when there is detectable evidence of spirochetal infection (OR: 10.61; 95% CI: 3.38-33.29) and over a four-fold increased occurrence of AD in a conservative risk estimate (OR 4.45; 95% CI: 2.33-8.52). We found over a five-fold increased occurrence of AD with Cpn infection (OR 5.66; 95% CI: 1.83-17.51). This study shows a strongly positive association between bacterial infection and AD. Further detailed investigation of the role of bacterial infection is warranted.

An earlier study reported “After the first report on the presence of Chlamydia pneumoniae (Cpn) in brains of patients with AD appeared in 1998, this bacterium has most often been implicated in AD pathogenesis. However, while some studies demonstrate a clear association between Cpn infection and AD, others have failed to confirm these findings.” [2010]

The association issue failure is the classic medical tunnel vision — believing that a single infection is responsible for a single condition.  My model is that an infection by “farming the gut” will cause similar sets of bacteria overgrowth that will result in the same symptoms being reported. 

Interesting also, that antibiotics are known to slow Alzheimer’s disease. http://www.webmd.com/alzheimers/news/20031009/antibiotics-may-slow-alzheimers 

Interesting that they are also the ones that have been effective for CFS – 

“a three-month course of the antibiotics doxycycline and rifampin