Dave Berg of Hemex Labs back in 1990 reported that most CFS patients have a high incidence of coagulation problems — usually genetic in origin. Getting a MD to tested for these disorders is usually very hard, and made worst by most insurance (including national insurance) not willing to pay for them unless you are having a stroke.
The following is what I have been able to track down for Coagulation SNPs on PubMed. Tomorrow — we will look at a canned set of SNPs that a different site has available.
- Magnitude: is the risk compare to normal people (0).
- At present, some information is hidden from download by 23andMe, the value shown is “DI” Diagnostic information
- Check download file and https://www.23andme.com/you/explorer/snp/ – often one will read DI and the other will give the value
- Note on getting tested for most: “Factor V Leiden mutation testing should be reserved for patients with clinically suspected thrombophilia” – Mayo labs.
- Australia Medical Insurance: “Medicare will pay only if the pathology request identifies in writing that the patient has a personal history of venous thromboembolism. A rebate for the proven defect(s) only can also be claimed for the first degree relative of a person who has a proven defect of any of the above. A family history of venous thromboembolism alone is not sufficient. The request must specifically identify the proven defect(s).” – AKA you can’t get there from here!
- Readings Recommended:
|SNP||23andMe||Links – Comments (Magnitude)||My values|
|rs1799963||i3002432||G20210A mutation of the prothrombin F2 gene G20210A, Positive: A:A(3). A:G(3) Normal G:G ( 0.293 when controlling for other SNPs)||G:G|
|rs6025||yes||Leiden mutation, R506Q, Positive: A:A 9x risk(3.5), A:G(2.3), G:G (0) (C=3.57).
A common mutation.
|rs7538157||n/a||BLZF1 A->C (C=2.69)||n/a|
|rs16861990||yes||NME7 A->C (C=2.02)||A:A|
|rs2038024||yes||SLC19A2 C->A (C=1.53) (impacts absorption of B1)||A:A|
|rs2519093||n/a||ABO A->T, A->C (A=1.69)||n/a|
|rs8176719||yes||ABO blood type O allele] ?-> C||DI|
|rs118203905||na||FV Hong Kong R306G ( G=1.59)|
|rs118203906||na||FV Cambridge R306T( T=1.59)|
|rs1801020||na||C46T ( T=1.63) A->G||G:G|
|rs2232698||yes||R67X ( T=1.59) C->G, C->A||G:G|
|rs5985 Factor Protector||yes||Factor Protector (2-4) C->A||A:A|
|rs121909548||n/a||A3845 ( T=2.277) C->G, C->A|
|rs9804128||yes||SNP Interaction [G on this one]||A:G|
|rs4784379||yes||SNP Interaction [A on this one]||A:G|
As you can see, I have the expected genetic mutation to pre-dispose myself to coagulation. As I result, I can be more specific in searching for appropriate supplements to reduce the type of risk each one creates. I can also regularly search PubMed for new articles. For example, searching for rs495828 -found 8 articles at present. For example
- associated with angiotensin-converting enzyme (ACE) activity and inflammation .. and with enalapril-induced cough 
For Rs6025, there are 35 articles. One of which states “The goodness of fit of the genetic and combined scores improved when significant SNP-SNP interaction terms were included.”, i.e. the more you have, the greater the combined effect.
Unlike the latter two vectors associated with CFS, I have significant activity here. The absence of those two other factors may be why I have been able to slip from CFS to remission three times — my recovery is not hampered by those other factors.