Dave Berg of Hemex Labs back in 1990 reported that most CFS patients have a high incidence of coagulation problems — usually genetic in origin. Getting a MD to tested for these disorders is usually very hard, and made worst by most insurance (including national insurance) not willing to pay for them unless you are having a stroke.
The following is what I have been able to track down for Coagulation SNPs on PubMed. Tomorrow — we will look at a canned set of SNPs that a different site has available.
- Magnitude: is the risk compare to normal people (0).
- At present, some information is hidden from download by 23andMe, the value shown is “DI” Diagnostic information
- Check download file and https://www.23andme.com/you/explorer/snp/ – often one will read DI and the other will give the value
- Note on getting tested for most: “Factor V Leiden mutation testing should be reserved for patients with clinically suspected thrombophilia” – Mayo labs.
- Australia Medical Insurance: “Medicare will pay only if the pathology request identifies in writing that the patient has a personal history of venous thromboembolism. A rebate for the proven defect(s) only can also be claimed for the first degree relative of a person who has a proven defect of any of the above. A family history of venous thromboembolism alone is not sufficient. The request must specifically identify the proven defect(s).” – AKA you can’t get there from here!
- Readings Recommended:
| SNP | 23andMe | Links – Comments (Magnitude) | My values | |
|---|---|---|---|---|
| rs1799963 | i3002432 | G20210A mutation of the prothrombin F2 gene G20210A, Positive: A:A(3). A:G(3) Normal G:G ( 0.293 when controlling for other SNPs) | G:G | |
| rs6025 | yes | Leiden mutation, R506Q, Positive: A:A 9x risk(3.5), A:G(2.3), G:G (0) (C=3.57). A common mutation. |
C:C | |
| rs7538157 | n/a | BLZF1 A->C (C=2.69) | n/a | |
| rs16861990 | yes | NME7 A->C (C=2.02) | A:A | |
| rs2038024 | yes | SLC19A2 C->A (C=1.53) (impacts absorption of B1) | A:A | |
| rs2519093 | n/a | ABO A->T, A->C (A=1.69) | n/a | |
| rs495828 | yes | T->G (T=1.65) | G:T | |
| rs8176719 | yes | ABO blood type O allele] ?-> C | DI | |
| rs118203905 | na | FV Hong Kong R306G ( G=1.59) | ||
| rs118203906 | na | FV Cambridge R306T( T=1.59) | ||
| rs1801020 | na | C46T ( T=1.63) A->G | G:G | |
| rs2232698 | yes | R67X ( T=1.59) C->G, C->A | G:G | |
| rs5985 Factor Protector | yes | Factor Protector (2-4) C->A | A:A | |
| rs121909548 | n/a | A3845 ( T=2.277) C->G, C->A | ||
| rs9804128 | yes | SNP Interaction [G on this one] | A:G | |
| rs4784379 | yes | SNP Interaction [A on this one] | A:G |
As you can see, I have the expected genetic mutation to pre-dispose myself to coagulation. As I result, I can be more specific in searching for appropriate supplements to reduce the type of risk each one creates. I can also regularly search PubMed for new articles. For example, searching for rs495828 -found 8 articles at present. For example
- associated with angiotensin-converting enzyme (ACE) activity and inflammation .. and with enalapril-induced cough [2014]
For Rs6025, there are 35 articles. One of which states “The goodness of fit of the genetic and combined scores improved when significant SNP-SNP interaction terms were included.”[2014], i.e. the more you have, the greater the combined effect.
Unlike the latter two vectors associated with CFS, I have significant activity here. The absence of those two other factors may be why I have been able to slip from CFS to remission three times — my recovery is not hampered by those other factors.