Looking at the current Genova Diagnostics – GI Effects / Stool Profiles

A CFS reader asked me to review his results and provided a  masked copy of their report (Attached).

In looking at the report, I would describe it as better than the ones in the past.

Page 1

Summaries:

  • High IgA levels
  • Imbalance
  • Lower Diversity
  • Signifiant less abundance

Page 2

  • High Triglycerides – the odds of this with CFS is twice that of controls [2010]. It is also associated with some inherited coagulation defects.
    Fecal secretory IgA is in reference range which seems inconsistent with Page 1
  • n-Butyrate is slightly below the normal range, Propionate is higher. – which suggests IBS with CFS
    • “Patients with inflammatory bowel disease have lower numbers of Butyricicoccus bacteria in their stools. Administration of B pullicaecorum attenuates TNBS-induced colitis in rats and supernatant of B pullicaecorum cultures strengthens the epithelial barrier function by increasing the TER.” [2013]
    • ” Elevated levels of amino acids (alanine and pyroglutamic acid) and phenolic compounds (hydroxyphenyl acetate and hydroxyphenyl propionate) were found inIBS” [2011]

Page 3

  • High level of:
  • Low level of:
    •  Bifidobacterium – typical – See my earlier post
    • Firmicutes/Bacteroidetes Ratio – this is almost identical to the results of another CFS patient [Post]
  • Not detectable:
    • Anaerotruncus colihominis – just 3 pub med articles
    • Coprococcus eutactus – IBS marker [2014]
    • faecalibacterium prausnitzii. ” A reduction of enteric microbiota diversity has been observed in UC patients, mainly affecting the butyrate-producing bacteria, such as Faecalibacterium prausnitzii, which can repress pro-inflammatory cytokines [2014] which may explain the low butyrate levels.
    • Colinsella aerofaciens [ just one article]

Page 4

Gastroinstentinal Microbiome – one issue: Klebsiella pneumonia was high as seen in a prior reader’s lab

Page 5

Microscopic Exam Results – no issues

Page 6

Additional results – no issues

Page 7

Prescriptive Agents:

Only Klebsiella pneumonia was listed and the antibiotics effective against it. This is a histamine producing bacteria and thus over population can result in histamine sensitivity and many CFS like symptoms.

Bottom Line

The results are the same pattern of other CFS patients. The strong IBS indicators suggests that Prescript Assist (which has resulted in IBS remission for a significant percentage) is a logical course of treatment.

Anonomous Report Shared With Me