Anti-TNF Supplements – Part 2

I am continuing the review of items listed at  “HOW TO INCREASE PERFORMANCE AND IMPROVE HEALTH BY INHIBITING TNF-ALPHA“ to identify items with good and bad impacts on microbiome. While taking TNF-alpha reducers is a good intent to reduce inflammation, some have adverse effects, similar to what I found is anticoagulant supplements.

He has a long list so I will not be doing deep searches and excluding items with no information. I have NOT verified if his assertions are backed by PubMed articles.

  • Bile (R)
  • Glycine (R)
    • L. plantarum HEAL 9 increase it [2014]
    • Elevated can indicate bile issues  [2014]
    • Improves sleep [Wikipedia]
  • Chromium  (R)
    • Increases  Actinobacteria and Acidobacteria [2012]
  • Sialic Acid (RR2)
    • A relative rise in Prevotella and Lactobacillus species was accompanied by a corresponding reduction in the genera Escherichia/Shigella, Ruminococcus and Eubacterium [2015]
    • Increase Clostridium difficile [2013] – especially if antibiotic taken at same time
  • Arginine (R),
    • shift in the Firmicutes-to-Bacteroidetes ratio to favor Bacteroidetes [2014]
  • Bromelain (R),
    • Inhibits enterotoxigenic Escherichia coli[1996]
  • Berberine (RR2), — NOT recommended for CFS
    • Decrease Clostridium difficile [2015]
    • Increased the generation of bile acids [2015]
    • lower counts of Escherichia coli but greater Lactobacillus[2013]
    • Blautia and Allobaculum, were selectively enriched, [2012]
    • berberine has demonstrated highly significant activity againstStaphylococcus, Streptococcus, Salmonella, Klebsiella, Clostridium, Pseudomonas, Proteus, Shigella,Vibrio, and Cryptococcus species [2011]
  • Apple polyphenols (R)
    • Increases Bifidobacterium [2015] – studies deal with Systemic Lupus Erythematosus Patients Microbiota, an interesting read
    • Decrease Lactobacillus spp, increase Bifidobacterium spp..[2014]
  • Silymarin (R), – Nothing
  • Honokiol  (R), – Nothing
  • Chinese Skullcap (R)/Baicalin (R), – Nothing
  • Ginkgo (R), – Nothing
  • Hespderidin (R), (in Citric) see apple literature above [2015]
  • Carnosine (R), – Nothing clear
  • Phytosterols (R),
    • Reduces  lactobacilli [1999]
  • Tart Cherry  (R) high in sorbitol, not recommended for some conditions.
  • Astaxanthin (R), – nothing
  • Astragalus  (R), -Not recommended for CFS
    • lactobacilli and Bacillus cereus increases,  Escherichia coli decreases [2009] [2012]
    • increases Bifidobacterium longum subsp. longum (two strains), B. longum subsp. infantis (three strains), Lactobacillus acidophilus , B. lactis,[2013]
  • Cat’s claw (R), – Nothing
  • Artemisinin (R)
    • Reduces  Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia.[2015]
  • Carnitine (R) – Nothing clear
  • Genistein (R) – Nothing clear
  • Amla/Gooseberry (R)
    • Increases  lactobacilli and bifidobacteria, decreases  Clostridium spp. and Bacteroides spp were decreased [2014]
  • CoQ10 (R), – Nothing significant
  • Magnolol (R) – Nothing
  • Echinacea (R) – Nothing
  • Chaga/Betulin (R) – Nothing
  • Bitter melon (R) – Nothing
  • Mastic gum (R),
    • reduces Mutans streptococci[2014]
    • Reduces Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Parvimonas micra [2014]
  • Oxymatrine (R) – Nothing clear
  • Red clover (R) – Nothing clear
  • NAG,
  • Quercetin (R)
    • Reduces  Firmicutes/Bacteroidetes ratio, reduces Erysipelotrichaceae, Bacillus, Eubacterium cylindroides [2015]
    • Feeds Escherichia coli, Stretococcus lutetiensis, Lactobacillus acidophilus, Weissella confusa, Enterococcus gilvus, Clostridium perfringens and Bacteroides fragilis [2014]
    • Inhibits  R. gauvreauii, B. galacturonicus and Lactobacillus sp [2012]
  • Rutin  (R) – no impact [2008]
  • Myricetin (R)
    • Increases B. adolescentis [2013]
  • Ashwagandha,
    • Inhibits Streptococcus mutans and Streptococcus sobrinus[2013]
    • Inhibits Escherichia coli, Salmonella typhi, Citrobacter freundii, Pseudomonas aeruginosa and Klebsiella pneumonia [2012]