The role of Stools Consistency and the Microbiome – A path for CFS Diet

Working off the premise that CFS (and many auto-immune disease) is based on a stable dysfunctional shift in gut bacteria, I found the following PubMed article interesting:

Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates. Vandeputte D, Falony G, Vieira-Silva S, Tito RY, Joossens M, Raes J. Gut. 2015 Jun 11. pii: gutjnl-2015-309618. doi: 10.1136/gutjnl-2015-309618.

One of the premise of my treatment model is that any thing that produces an objective change of gut bacteria is a good change. One path has been selective probiotics, this is looking at another path.

Oh, what do I mean by objective change?

  • Frequency
  • “Floaters” vs “Sinkers”
  • The  bouquet of the stools — who says that smellless stools are healthy???
  • Consistency: pellets, loose, solid, diarrhea.

famdocquestions-1

Another path may be to alter stool consistency by changing of diet. A diet high in roughage can often result in 3-5 stool movements a day, other’s may have it as an event that occurs every few days only.

Results Stool consistency strongly correlates with all known major microbiome markers. It is negatively correlated with species richness, positively associated to the Bacteroidetes:Firmicutes ratio, and linked to Akkermansia and Methanobrevibacterabundance. Enterotypes are distinctly distributed over the BSS-scores. Based on the correlations between microbiota growth potential and stool consistency scores within both enterotypes, we hypothesise that accelerated transit contributes to colon ecosystem differentiation. While shorter transit times can be linked to increased abundance of fast growing species in Ruminococcaceae-Bacteroides samples, hinting to a washout avoidance strategy of faster replication, this trend is absent in Prevotella-enterotyped individuals. Within this enterotype adherence to host tissue therefore appears to be a more likely bacterial strategy to cope with washout.”

For clarity:  (low scores: firm stool and slow transit, high scores: loose stool and fast transit).

Remember where we are!!!

We have a stable dysfunction gut microbiome. We want to make it unstable and hopefully nudge towards  a functional one.

Food to consider (typically not in most Western diet – typically we eat only 1/2 of the recommended fiber intakes of 20-35 g/d,[1998])

  • Bran – Rice, Wheat and Oat brans are different in their impact
    • ‘The apparent digestibility of plant-derived neutral sugars decreased significantly when wheat but not oat bran was consumed. The apparent digestibility of neutral sugars provided by wheat bran was 56%; the apparent digestibility of those provided by oat bran was 96%.” [1998]
    • Wheat bran extract alters colonic fermentation and microbial composition, but does not affect faecal water toxicity: a randomised controlled trial in healthy subjects.[2014]
    • “rice bran phytosteryl ferulates mediate anti-inflammatory effects by down-regulating the inflammatory transcription factor, nuclear factor κB (NF-κB), which in turn reduces expression of inflammatory enzymes such as COX-2 and iNOS, and proinflammatory cytokines such as IL-1β, IL-6 and TNF-α.” [2011]
    • “support that SRB[Heat-stabilized rice bran] consumption can affect gut microbial metabolism” [2015]
    • “As markers of CRC risk, , faecal water genotoxicity was determined using the comet assay and faecal water cytotoxicity using a colorimetric cell viability assay. Intake of WBE induced a shift from urinary to faecal 15N excretion, indicating a stimulation of colonic bacterial activity and/or growth. Microbial analysis revealed a selective stimulation of Bifidobacterium adolescentis.”[2014]
    • Suggestion: Have porridge for breakfast and add 1/4 cup of some form of bran to it.
      •  A bran muffin has typically 1/8 cup of bran in it, so the alternative would be two a day.
  • A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs
    • A diet low in FODMAPs reduces symptoms of irritable bowel syndrome.Halmos EP, Power VA, Shepherd SJ, Gibson PR, Muir JG. [2014]
    • Low FODMAP diet information
    • “Diets differing in FODMAP content have marked effects on gut microbiota composition. The implications of long-term reduction of intake of FODMAPs require elucidation.”[2015]
    • Suggestion: Take Prescript Assist and/or Align concurrent with this diet change, both have been shown effective for IBS.

Full Article.