A reader wrote ”
- Fighting antibiotic resistance in the intensive care unit using antibiotics.
- “with a 28-day on-off regimen with tobramycin or aztreonam” 
- Antibiotic rotation strategies to reduce antimicrobial resistance in Gram-negative bacteria in European intensive care units: study protocol for a cluster-randomized crossover controlled trial .
- Antibiotic rotation for febrile neutropenic patients with hematological malignancies: clinical significance of antibiotic heterogeneity.
- ” implementing antibiotic cycling showed statistically significant improvements in susceptibility to ceftazidime and piperacillin/tazobactam, while susceptibility to imipenem remained unaltered. Susceptibility of E. coli isolates to piperacillin/tazobactam improved significantly, trend analysis showing this improvement to persist over the study period .” 
There are problems with MDs adopting it, because it is more complex then using just one, and there are likely misconceptions that somehow by prescribing two or more, “you’ll increase antibiotic resistance” because you are using twice the number of antibiotics and thus doubling the odds of antibiotic resistance — totally wrong!
Supplements – Organic
The first part of supplements, supplements/herbs/spices with anti-infection characteristics are simple — the above applies because they are anti-infection. This includes Ashwagandha (Withania Somnifera). Herbs like ashwagandha mechanism of action appear often to be via impact on bacteria or virii.
- Identification of anti-biofilm components in Withania somnifera and their effect on virulence of Streptococcus mutans biofilms.
- Antibacterial activity of Withania somnifera against Gram-positive isolates from pus samples (2014).
- Antimicrobial activity and probable mechanisms of action of medicinal plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus.
Another adaptogen, Rhodiola rosea (commonly golden root, rose root, roseroot, western roseroot, Aaron’s rod, Arctic root, king’s crown,lignum rhodium, orpin rose), is similar
- Rhodiola inhibits dengue virus multiplication by inducing innate immune response genes RIG-I, MDA5 and ISG in human monocytes .
- Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles.
- Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities.
Hence, rotation of all herbs is my preferred recommendation. If one is an EBV antiviral, then get a list of other anti-EBV herbs (documented by pub med please!!) and rotate them every 1-2 weeks.
- Effects of rotation of topical vitamin D3 in chronic plaque-type psoriasis. ” Our study showed that switching one VD3 reagent to another VD3 reagent could improve the objective scores of the psoriasis symptoms. It was surprising that switching to calcipotriol or other reagents improved the eruption in a similar way.”
- ” Because of the chronic course of the disease, appropriate choice of therapy in particular stage of the disease, so-called rotation therapy, is of paramount importance.”
- ” children showed significant academic and behavioral improvements within a few weeks or months of open-label treatment with nutrient supplements. …. For those who discontinued, it took at least 1 year to begin to see the first indications of decline in academic performance, and another year for their grades to drop significantly.” 
- So effective supplements have quick response and very slow reversal, suggesting no loss from pulsing.
“Unproven diet therapies for patients with CFS include megavitamin/mineral supplements; royal jelly and other dietary supplements; and elimination, avoidance, and rotation diets. Claims that these therapies relieve CFS symptoms and promote recovery are anecdotal and have not been substantiated by clinical research. The yeast-avoidance and sugar-free diets, both promoted to combat Candida albicans overgrowth, are of questionable value in treating patients with CFS. …. Diet strategies that call for the avoidance of food additives, preservatives, sweeteners, and other ingredients are not supported by available evidence and are not practical for patients with CFS.”  – some 23 years later, these claims are still circulating in the CFS patient’s community. The absence of studies finding them effective should not be ignored. I recall in 2000, many people trying these with good initial (aka Placebo) response that disappeared quickly.