CFS patients are often found to low on one vitamin, amino acid, etc. The logical approach has been to supplement those in the hope that it would help. Too often, there was no significant change found in clinical studies. The why may well be connected to an absence of gut bacteria needed to transform/transport these supplements into the body.

The following is a list of supplements demonstrated to have positive effects in clinical studies not on the prior lists.

• Vitamin D3 – Often 15,000 to 20,000 IU per day is need to keep a CFS/FM patient at the top end of the normal range where there can be a major reduction of symptom severity. Vitamin D2 is NOT recommended
• CoQ10  300 mg/day – Studies in this post.
• Magnesium

Other were included in earlier list: Piracetam, Licorice, D-Ribose.

B12 is also in the list, with preference for Lactobacillus Reuteri (produces B12 and this species is abnormally low with CFS patients). While L.Reuteri also produces lactic acid, the goal is to reduce lactic acid and not to totally eliminate it.