In my last post I stumbled on a PubMed article that appears to identify two probiotics that should reduce histamines:

• “We found that mice that received GG and PJS[Propionibacterium freudenreichii] exhibited significantly lower numbers of intestinal mast cells compared with control mice.”[2013]

The implied logic is simple, less mast cells in the intestines, the less histamines to release. When I had visited this item before, I was searching directly for histamines and probiotics.  Changing the search to probiotics and mast cells I came up with 47+ articles.  “Accordingly, subsets of patients with IBS show higher numbers and an increased activation of mucosal immunocytes, particularly mast cells. “[2012]

“Although the effect of probiotics on allergic responses is different depending on the strains, doses, and experimental protocols, animal studies generally …reduction of degranulated mast cells,” [2009]

From these articles, I found the following interesting reports:

• Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression [2015].
• Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet [2013].
• Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells [2011].
• “Oral treatment with both viable and heat-inactivated Lact. sakei probio 65 (isolated from Kimchi ) inhibits skin inflammation and AD-like skin lesions, as well as mast cell activation.”[2013]
• Systemic effects of ingested Lactobacillus rhamnosus: inhibition of mast cell membrane potassium (IKCa) current and degranulation.[2012] “the systemic effects of certain candidate probiotics may include mast cell stabilization and such actions could contribute to the beneficial effect of these organisms in allergic and other inflammatory disorders.”
• “numbers of total leukocytes and mast cells in BALF induced by OVA challenge were significantly suppressed by oral administration of LFK.[lysed Enterococcus faecalis FK-23 (LFK) orally for 28 days] [2012]
• “L. casei protected from anaphylaxis and arthritis, and inhibited mouse mast cell and human basophil activation.”[2011]
• “that high doses of non-pathogenic E. coli bacteria can function as a strong, direct inhibitor of MC [Mast Cell] degranulation.” [2008] – likely Mutaflor, i.e. E.Coli Nissle 1917

Following on to  the prior post,  we end up with the following being a group of mast cell inhibitors that appears to be fine to take together.

• Mutaflor (E. coli Nissle 1917) x Securil (Propionibacterium freudenreichii) x  Culturelle (Lactobacillus rhamnosus GG) x Yakult (Lactobacillus Casei)