Review of Probiotics from EU and Canada

See Cost per Billion CFU Post for relative pricing. Except for specialized strains that have been well tested, it is impossible to be objective on the benefit of one product over the other. The amount of viable Billion CFU is most meaningful (IMHO) given the absence of real information….

Walmart – Canada

I was in  Canada today and dropped by Walmart. The reason is that I have noticed some brands of probiotics there that I have not seen elsewhere. There were several there today, unlike many brands — the strains were listed.

These probiotics are from WN Pharmaceuticals, Coquitlam, BC Canada,

Bifidobacterium BB536

  • Available via Amazon.Ca, does not require refrigeration.
  • 100%, 5 Billion CFU . 44 Pub Med articles  $5.00 Canadian  15 capsules. Cost per BCFU:  $0.05 US
    • “Supplementation with BB536 was well tolerated and reduced ulcerative colitis scores,” [2016]
    • “showed significantly increased fecal levels of pimelate, a precursor of biotin, and butyrate in the BB536-HGM group … the proportion of Eubacterium rectale, a butyrate producer, was significantly higher in the BB536-HGM group” [2015]
    • ” B. longum BB536 supplementation significantly reduced total cholesterol, liver lipid deposition and adipocyte size, and positively affected liver and kidney function. These effects were significantly increased in the presence of inulin and M. pajang fibrous polysaccharides.” [2015]
    • BB536 has positive effects on establishing a healthy intestinal microbiota early in life, and it also plays an important role in improving the Th1 immune response.” [2015]
    • ” supplementation of bifidobacteria is effective in primary preventing allergic diseases.” [2014]
    • BB536 ingestion modulated the intestinal environment and may have improved the health care of elderly patients receiving enteral feeding.” [2013]
    • ” groups fed a cholesterol-enriched diet supplemented with yoghurt containing… B. longum BB536 had significantly lower plasma total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol… faecal excretion of bile acids was markedly increased in the rats fed the yoghurt containing …B. longum BB536 ” [2012]
    • “B. longum BB536 and L. rhamnosus HN001 used in combination show no antagonism to each other” [2015]
    • Oral administration of Bifidobacterium longum ameliorates influenza virus infection in mice. [2011]
    • Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice. [2008]
    • In 2013, Carrie, a readed commented ” I have used BB536–Bifidobacterium longum with great results.”

    • Recommendation: BUY – good price, good benefits

Complete Probiotic Multi Strain

This is available via SwansonVitamins.com and Amazon.Ca does not require refrigeration, $14 for 50 capsules, 5 BCFU – Cost per BCFU $0.06

  • Lactobacillus casei 1.5 BCFU
  • Lactobacillus rhamnosus 1.25 BCFU
  • Bifidobacterium breve 0.75 BCFU
  • Bifidobacterium longum 0.75 BCFU
  • Lactobacillus acidophilus 0.75 BCFU

Recommendation: The first 4 are all good ones, and the cost per BCFU is good. Buy.

Probiotic 30 Billion

  • 30 Capsules for $15.00 Cost per BCFU $0.016 
  • Amazon.ca sells
  • Containing the following:
    • L. Casei (HA-108) 5.88 BCFU – Udo: 0.75)
    • B. Breve (HA-129) 4.5 BCFU
    • B Longum (HA-135) 4.5 BCFU
    • L Rhamnosus (HA-111) 4.5 BCFU – Udo 6.25
    • L. Acidophilis (HA-122) 4.2 BCFU
    • L. Plantarium (HA-119) 4.2 BCFU
    • L.Rhamnosus (HA-500) 2.1 BCFU
    • L. Helveticus (HA-501) 0.4 BCFU
    • Many of the strains are in Udo’s Choice Super 8 Plus Probiotic — but the ratios are different.  What caught my eye was that the dominate one was L.Casei and L. Acidphilis was a lot lower then other mixtures. These strains are available to manufacturers such as Lallemand Health Solutions; with firms mixing their own ratios.

European Probiotics

In Europe, probiotics are actually more challenging to get than in the US. Added to the problem of finding is also much higher costs.

Colonease Plus

  • 23,80 euros  PD 19,20 euros, £10.99
  • 4 BCFU of Lactobacillus acidophilus, Bifidobacterium lactis & Lactobacillus bulgaricus
  • Recommendation: Do Not Use. Acidophilus is the main bacteria and should be avoided

Prolife Forte  Naturlife

  • 18,74 euros PD 15,30 euros Cost per B CFU: $0.35
  • 2 BCFU Bacillus coagulans MTCC 5260 AKA Unique IS-2 AKA ATCC PTA-11748 
    • 2011 Paper, 2014 FDA Filing
      • ” was found to be sensitive to majority of antibiotics tested with the exceptions of Bacitracin, Colistin, Methicilin and Metranidazole and Streptomycin, while intermediate for Clindamycin, Doxycycline, Erythromycin, Penicillin and Tetracycline. “
      • “were slight reductions in total cholesterol (11%) and LDL (0.8%), whereas an increase in HDL cholesterol levels (3.6%) was noted. “
      • ” 80% of the probiotic group subjects showed significant positive response as revealed by reduction of vaginosis symptoms as compared to the control group which exhibited reduction in 45% subjects only. ” Clinical Study of Bacillus coagulans Unique IS-2 (ATCC PTA-11748) in the Treatment of Patients with Bacterial Vaginosis. [2012]
      • “Treatment with B. coagulans Unique IS2 decreased mean values for duration of diarrhea, frequency of defecation, and abdominal pain, while consistency of stool improved. “
  • Recommendation: Secondary list – has microbiome altering behavior

Proflora Max

  • 19,40 euros 16,20 euros, 45 capsules – cost per BCFU: $0.36
  • 1 BCFU containing
    • Bifldobacterium infantis ,
    • Bifldobacterium lactis,
    • Bifldobacterium longum,
    • Enterococcus Faecium,
    • Lactobacillus Acidophilus
    • Lactobacillus Casei
    • Lactobacillus Salivarius,
    • Lactobacillus Plantarum
    • Lactobacillus Lactis
  • Recommendation: Cost per BCFU is high, not the best use of funds

Acidophilus Nature Plus

  • 18,5 euros, $9   90 capsule of 40 million cells, Cost per BCFU $2.77
  • Recommendation: NO NO NO — This is only Lactobacillus Acidophilus — the bacteria to AVOID. Cost per BCFU is VERY high.

Acidophilus Avanzado Solgar

  • $35 for 120 capsules. Cost per BCFU $0.20
  • Contains:
    • L. Acidophilus LA-5, 0.3 BCFU
    • L. Rhamnosus GG, LGG 0.3 BCFU
    • L. Paracasei, L.Casei 431  0.3 BCFU
    • B. Lactis BB-12 0.3 BCFU
    • S. Therophilus TH-4 0.3 BCFU
  • Recommendation: Acceptable if there are problems getting other probiotics.

Nature Plus Tri dophilus

  • 3 BCFU, 60 Capsules, $17, Cost per BCFU $0.09
  • Contains:
    • Lactobacillus acidophilus (2 billion viable cells**)
    • Bifidobacterium longum & Bifidobacterium bifidum (250 million viable cells**)
    • Enterococcus faecalis (750 million viable cells**)
  • Recommendation: Mainly L. Acidophilus which we wish to avoid.