Itching, Hives, Histamine and Bacteria

In the past I have written about histamine intolerance[ Mar 2014] being a possible CFS mechanism. I also wrote about Non-histamine probiotics. After that post, there was a 2015 paper on Mast Cell and Autoimmune Diseases (“Mast Cells promote inflammation in the same way like TNF”). In this post, I want to look at what we know about specific bacteria that may cause itching, hives, or to use the medical term , urticaria. Medical opinion is that all of these are due to histamine release, so we are effectively looking at bacteria that can cause histamine to be release from mast cells.

Helicobacter pylori: A significant and treatable cause of chronic urticaria and angioedema. [2015]
“Mycoplasma pneumoniae has been shown to be an important cause of common disorders such as urticaria,” [2015] – incidence of mycoplasma infections in CFS populations is much higher than the general population. [Systemic Mycoplasma blood infection in fibromyalgia and chronic fatigue syndrome].[2004]
” Many bacterial infections have been associated with urticaria manifestation, such as Helicobacter pylori, Streptococcus, Staphylococcus, Mycoplasma pneumonia, Salmonella, Brucella, Mycobacterium leprae, Borrelia, Chlamydia pneumonia, and Yersinia enterocolitica.” [2014]
Our old “friend” Staphylococcus aureus post[with herbs to address] is cited in this [2014] paper
Herpesvirus-associated acute urticaria: an age matched case-control study[2013].

Bottom Line

There are many virus and bacteria that are associated with urticaris — which I assume is primarily caused by histamine release. IMHO, Staphylococcus it the preferred one to initially target and there was a pub med reports in 2001 of eradication of Staphylococcus leading to CFS remission. As well as staphylococcus toxoid on FM and CFS resulting in major positive results in 2002.

I have updated my staphylococcus aureus-the-cfs-maintainer post with more herbs and spices that have evidence on PubMed of being effective. One word of caution, some may dump chemicals triggering histamine release when they are killed — so have DAO and anti-histamine handy!

dikirk 5:51 pm on March 7, 2016

Your blog is so interesting and well researched. I often dip in and out of your blog posts.Thanks
fabulouslyfatigued 8:53 am on March 8, 2016

Hello! I was diagnosed with solar urticaria in high school. I was diagnosed recently with CFS and Fibromyalgia (along with some other disorders). This is the first thing I’ve seen connecting urticaria and CFS. Extremely interesting. I’d love to see more research on this! Thanks for posting.
- lassesen 3:33 am on March 9, 2016
  
  If you are willing to be a guinea pig, you may wish to try some of the herbs on this page and see what your response is.
  
  https://cfsremission.wordpress.com/2016/02/01/staphylococcus-aureus-the-cfs-maintainer/
  
  Possible responses are:
  *ZERO
  * minor to major herx followed by possible symptom reduction
  * reduce symptoms without herx
  
  This is the bacteria that seems to be involved often (and account for at least some symptoms).
  - fabulouslyfatigued 4:39 am on March 9, 2016
    
    Thanks for your reply. I’m willing to try just about anything if it’ll help.
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George 12:28 am on June 5, 2021

Very interesting article- i developed urticaria suddenly one day in jan. 2010 and for a 3 months it became severe and since then for 10 years i was on 2x10mg loratadine every day. Beside that i was very healthy and active person .In 2020 i developed CFS/ME , i was bedbound for 60 days and mostly home bound after that and today.The interesting fact is the urticaria disappeared with the beginning of the CFS/ME. So that is the way i came to this article.