3 Biomarkers and the Microbiome Model

The joy (and bane) of having a model is that when new information arrives, you can see if it supports or disagrees with the model. In some cases, it become a neutral — not sufficient information to make a determination.

The National ME/FM Action Network did an announcement of three bio markers, from Australia, Canada and the United Kingdom (i.e. the British Commonwealth!)

Testing against the model

Looking at miRNA

  • “Our results suggest that 68 bacterial RNAs predicted from 37 different bacterial genomes have predicted secondary structures potentially able to generate putative microRNAs that may interact with messenger RNAs of genes involved in 47 different human diseases.” [2014] i.e. bacteria DNA is adopted into the human cells, producing miRNA.
  • “a third mycobacterial species, M. marinum, did express an ∼23-nt small RNA that was bound by RISC and derived from an RNA stem-loop with the characteristics expected for a pre-microRNA.” [2014]

Bottom Line

One set of markers is strongly associated with microbiome shifts. The second with Vitamin D levels.  miRNA can cross from bacteria (including gut bacteria) into human cells. All of these tests appear consistent with the microbiome model

While the tests may help with getting a faster diagnosis, they do not appear to lead to treatments.