Microbiome, Ischemic Stroke and SPECT

This week there was a new article published in nature “Commensal microbiota affects ischemic stroke outcome by regulating intestinal” [2016]. A news story in Spanish is here. “The possibilities being considered are focused on stroke prevention, which could be achieved with probiotics to strengthen beneficial microorganisms for these diseases, the implementation of appropriate diets or even applying transplants fecal for patients who have suffered a heart attack cerebral.”

I have know CFS suffers who frequently had Transient Ischemic Strokes(TIA) prior to antibiotic treatment. They disappeared afterwards (and have stayed away for 10+ years). Additional studies include:

In terms of CFS patients we have:

  • Hypercoagulation, see this post for links to studies
  • SPECT:
    • “Radiological imaging studies (SPECT, Xe-CT, and MRS) revealed decreased blood flow in the frontal and thalamic areas, and accumulation of choline in the frontal lobe.” [2004]
    • ” Regional blood flow studies by single photon-emission computerized tomography (SPECT) have been more consistent. They have revealed blood flow reductions in many regions, especially in the hind brain. Similar lesions have been reported after poliomyelitis and in multiple sclerosis–in both of which conditions chronic fatigue is characteristically present. In the well-known post-polio fatigue syndrome, lesions predominate in the RAS of the brain stem. ” [1997]
    • ” Patients with chronic fatigue syndrome had significantly more defects throughout the cerebral cortex on SPECT scans than did normal subjects (7.31 vs 0.43 defects per subject, p < .001). SPECT abnormalities were present in 13 (81%) of 16 patients, vs three (21%) of 14 control subjects (p < .01). SPECT scans showed significantly more abnormalities than did MR scans in patients with chronic fatigue syndrome(p < .025).” [1994]
    • “Compared with the Normal Control  group, the CFS group showed significantly lower cortical/cerebellar rCBF ratios, throughout multiple brain regions (P < 0.05). Forty-eight CFS subjects (80%) showed at least one or more rCBF ratios significantly less than normal values. The major cerebral regions involved were frontal (38 cases, 63%), temporal (21 cases, 35%), parietal (32 cases, 53%) and occipital lobes (23 cases, 38%). The rCBF ratios of basal ganglia (24 cases, 40%) were also reduced.” [1992]

Bottom Line

The microbiome impact on the brain is being recognized more and more recognized. Many of the autoimmune diseases that has cognitive issues are also ones with significant shifts of the bacteria in the gut. Reversal of those shift may result in reversal of cognitive issues — my own experience is that I had a SPECT that a radiologist read as early Alzheimer’s Disease during the last relapse of CFS, I was having severe memory issues. With remission, the brain returned to normal and memory is fine today — working as a senior information technologist..