TNF-Alpha and Probiotics

My last post looked at faecal calprotectin and which probiotics can lowere it.  This caused me to look explicitly at TNF-alpha(or tumor necrosis factor-α) and probiotics. We saw that one strain of Lactobacillus Acidophilus increases TNF-alpha.  TNF-Alpha is high in CFS patients (and most autoimmune patients)[2016] and should not be raised higher.

” is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons.[3]” [Wikipedia]

TNF-Alpha reducing probiotics

  • DECREASE : Bacillus coagulans..significant decrease in the production of pro-inflammatory cytokines, such as TNF-α [2016]
  • DECREASES: Clostridium butyricum (CB) capsules. [2016]
  • DECREASE: Saccharomyces cerevisiae RC016 [2016]
  • DECREASE: Lactococcus chungangensis CAU 28(T)…reduced the release of β-hexosaminidase and histamine in human mast cell cells..  suppressed the production of … tumor necrosis factor-α [2016]
  • DECREASE: B. lactis HN019 … a significant decrease in tumor necrosis factor-α [2016]
  • DECREASE: clostridium butyricum CGMCC0313.1… reduced tumor necrosis factor (TNF)-α level [2016]
  • DECREASE: Bifidobacterium breve, Lactobacillus casei, Lactobacillus bulgaricus and Lactobacillus acidophilus [2016]
  • DECREASE: Lactobacillus plantarum HM218749 [2016]
  • DECREASE: “Pseudomonas bacteria demonstrated that probiotic therapy inhibited septicemic accumulation of the pathogen in remote organs. In addition, probiotic therapy successfully suppressed the infection-dependent induction of TNF-α and interleukins 6 and 10 in the liver.” [2016]
  • DECREASE: “a probiotic mixture, including Lactobacillus and Bifidobacterium species,” [2016]
  • DECREASES: B. bifidum, L. acidophilus and Ba. coagulans [2016]
  • DECREASES: Clostridium leptum [2016]
  • DECREASES: VSL#3 [2016]
  • DECREASES: Lactobacillus plantarum WLPL04 [2016]
  • NONE:  Lactobacillus planetarum A7 [2016]
  • INCREASES: Pediococcus pentosaceus [2017]
  • INCREASES: Bacillus cereus [2016]
  • INCREASES:  Lactobacillus plantarum BF-LP284 (H-Lp) [2016]
  • INCREASES: Lactobacillus rhamnosus GG [2016]
  • INCREASES: Lactobacillus delbrueckii subsp. lactis CIDCA 133 “The production of TNF-α (a protective cytokine in B. cereus infections) by dendritic cells was increased in the presence of lactobacilli[2016].

Available Probiotics

  • Mutaflor… expression of the pro-inflammatory cytokines IL-6 and TNF-α was higher [2012]