A reader wrote about constant pain. One common cause of pain in FM is low oxygen level – typically caused by one or more of the following:
- Vasoconstriction (narrowing of blood vessels, reducing oxygen delivery volume)
- Fibrin deposits (blocking access of the blood’s oxygen into tissue)
- Coagulation (thick blood) – blood moves slower, so less oxygen is delivered.
- Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial .
- Pain severity is associated with muscle strength and peak oxygen uptake in adults with fibromyalgia . “lesser values of … peak VO2 uptake were predictive of greater pain severity scores.”
- Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia . “However, tissue relative oxygen extraction fraction during exercise in subjects with FM was significantly lower than in healthy controls, and the half-times of oxygenation recovery … were significantly longer following fatiguing exercise and cuff occlusion.” – i.e. the ability to deliver oxygen is impaired.
- “Women with fibromyalgia had greater impaired of functional capacity, exacerbation of pain and exertion during the 6 Minute Walk Test when compared to healthy women… In the fibromyalgia group, there was a negative correlation between distance in 6MWT and oxygen consumption” the further walks, the less oxygen was consumed… contrary to normal people… 
I have often taken a vasodilator. Brain fog and the occasion pain disappeared. Which one, flushing niacin, which often create a major flush on occasion still. Unfortunately, the reader is unable to take niacin. The following are alternatives, my first choice would be 800 mg of magnesium per day, while slow — magnesium is reported to improve fibromyalgia 
- L-arginine is an amino acid that is a vasodilator. According to studies, it is higher in urine of CFS patients, but is generally low . It also shifts the Firmicutes-to-Bacteroidetes ratio to favor Bacteroidetes  which unfortunately is the same type of shift seen in CFS “a higher relative abundance of Bacteroidetes and lower abundance of Firmicutes observed in ME/CFS patients compared to healthy controls.” 
- ” It is suspected that the cerebral vasodilator effects of Danshen and Gegen produced either on their own or in combination, can help patients with obstructive cerebrovascular diseases.” 
- Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time . “both rosemary and common thyme significantly inhibited platelet reactivity and enhanced the flow-mediated vasodilation.”
- “Common thyme and rosemary showed significant antithrombotic activity in vitro and in vivo. Neither herb affected flow-mediated vasodilation.” 
- Chakalaka-induced vasodilatation in patients with chronic myeloid leukaemia on tyrosine kinase inhibitors . Chakalaka is a South African vegetable relish,
- ” our study confirmed the functional effects of fennel derived-nitrites using in vitro and ex vivo models that describe the promotion of angiogenesis, cell migration, and vasorelaxation.” 
- ” the effects of a dietary supplement containing β-hydroxy-β-methylbutyrate (HMB), glutamine and arginine on endothelial-dependent vasodilation of older adults…revealed a 27% increase in flow-mediated dilation among the treatment group” 
- Glutamine, N-acetyl cysteine and zinc in combination improves symptoms http://www.ncbi.nlm.nih.gov/pubmed/19112401 (2008)
- “The current meta-analysis, therefore, does not provide unambiguous evidence to support the use of fat-soluble vitamin supplements (Vitamin D and E) to improve fasting flow-mediated vasodilation in adults.” 
- “Garlic-derived polysulfides stimulate the production of the vascular gasotransmitter hydrogen sulfide (H2S) a… which induce smooth muscle cell relaxation, vasodilation, and BP reduction.” 
- Some sites mention [source] [source]
- Catuaba Catuaba, Erythroxylum catuaba
- Cayenne Pepper Cayenne Pepper, Capsicum minimum
- Ginger Root Ginger Root, Zingiber officinale
- Ginkgo biloba Ginkgo biloba, Ginkgo biloba L.
- Gotu Kola Gotu Kola, Centella asiatica (L.)
- Jiaogulan Jiaogulan, Gynostemma pentaphyllum
- Lemon Balm
- Lotus Lotus, Nelumbo nucifera
- Olive Leaf
- Orange Orange, Citrus sinensis, Citrus spp.
- Parsley Parsley, Petroselinum crispum
- Schisandra Schisandra, Schisandra chinensis
- “According to Linus Pauling Institute, magnesium supplement at a dose of 730 milligrams per day can cause a 12-percent improvement in the normal dilation response of arteries. ” [source]
Back in 2012, I did a series of posts on those available as supplements
All of these also increases penetration of antibiotics into tissue (up to 10x higher concentrations).
Coagulation (thick blood)
This is more complex, this post lists some items.