My last post lead me to discover that resveratrol (RES) impacts the microbiome as shown in the diagram below. In particular, reduced unclassified bacteria. I had cover this in
- Resveratrol Revisited in 2015 suggested dosage 500-1000 mg/day
- strong antioxidant activity, antibacterial, antiviral, anticarcinogenic, anti-inflammatory, anti-allergic, and vasodilatory actions, inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility 
- Japanese Knotweed Rhizome – Polygonum cuspidatum (very high in it) – up to 5 gm/day
- Inhibits Coxsakievirus
Resveratol and the Microbiome
- “Cell extract of B. infantis showed the highest effect on the deglycosylation of piceid to resveratrol, already after 30 min.” [2016 Full Text] – in other words, this occurs naturally but with decreased bifidobacterium, the natural levels may be reduced.
- “Out of 13 bacterial strains tested, Lactobacillus kimchi JB301 could completely convert polydatin into resveratrol.” 
- “Resveratrol improves the gut microbiota dysbiosis induced by the HF diet, including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Enterococcus faecalis, and increasing the growth of Lactobacillus and Bifidobacterium.” 
- “resveratrol showed strong potential as antibiotic alternatives for reversing the adverse effects of weaning stress on growth performance, immunity and microbial environment in E. coli and Salmonella-challenged piglets.” 
- “shows that the intake of polyphenols contained in natural sources, such as hydroxytyrosol, tyrosol, oleuropein (olives), naringin and hesperidin (Citrus fruits), resveratrol, procyanidins or oligomeric procyanidin (grapes or grape seed extracts), (-)-epigallocatechin gallate (green tea) and quercetin (grapes, green tea) etc., are able to modulate chronic inflammatory diseases, such as type 2 diabetes, rheumatoid arthritis, inflammatory bowel disease,” 
- “Resveratrol increased lactobacilli and bifidobacteria as well as diminished the increase of enterobacteria upon DSS treatment. Resveratrol significantly protected the colonic mucosa architecture, reduced body weight loss, diminished the induced anemia and reduced systemic inflammation markers, colonic mucosa prostaglandin E(2), cycloxygenase-2, prostaglandin E synthase and nitric oxide levels. In addition, the expression of 2,655 genes in distal colon mucosa related to important pathways was varied. These results reinforce the concept of resveratrol as a dietary beneficial compound in intestinal inflammation at doses possibly attainable with resveratrol-enriched nutraceuticals.” 
Microbiome related changes
- “The bioavailability of resveratrol is highly influenced by several factors such as the food matrix” 
- “Resveratrol treatment of mice with established heart failure (HF) enhances exercise performance, which is associated with alterations in whole body and skeletal muscle energy metabolism. Overall, our pre-clinical data suggest that resveratrol supplementation may effectively improve fatigue and exercise intolerance in HF patients.” 
- ” Therapeutical interventions that aim to increase Glutathione concentrations in vivo include N-acetyl cysteine (NAC); Nrf-2 activation via hyperbaric oxygen therapy; dimethyl fumarate; phytochemicals, including curcumin, resveratrol, and cinnamon; and folate supplementation.” 
- NAC – Improves 59% of CFS patients after 10-14 months (2008)
- ” our data provide evidences that the intake of resveratrol associated with rice bran oil plays antinociceptive and antidepressant actions probably through reducing reactive species and suggests the involvement of oxidative stress in this model of fibromyalgia as possible underlying mechanism of pathogenesis of the disease.” 
- Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells .
- “In conclusion, our study showed that hyper-anxiety associated with prediabetic condition is ameliorated[reduced] by resveratrol [grape seed extract] through modulation of sirtuins,”
Resveratrol is strongly recommended to be part of your daily supplements. There is no apparent need to rotate (since it is naturally occurring in the body) if you are using an extract. If you are obtaining it from Japanese Knotweed Rhizome and other herbs and spices high in it, you should rotate — because other anti-infection substances in the mixture may become ineffectual over time. My preference (based on some studies) is to obtain things from the natural source and not to use refined extracts — there is often many substances that perform a helping hand to the active(studied) ingredient.
Given this update of information, I would be inclined to suggest around 1000 mg/day of resveratrol . Of course, this should be reviewed and discussed with your knowledgable medical professional.
Costs for 1000 mg using Amazon.com
- 64-70 cents (Not organic) “Resveratrol”
6-10 cents Nature Restore Organic Japanese Knotweed Powder (buying in 250 grams – 1 lb bulk)
- 30 cents grape seed extract (bottled), 7 cents as bulk