A reader wrote:

“Another thing I take to eliminate brain fog is Bacopa Monnieri. It’s sometimes called Brahmi too but Brahmi can also be another thing in Indian medicine (I think?). I don’t claim to be an expert on Ayuveda but all I know is there are several brands that call it each name and all of them work for me. Its effect is almost as strong as modafinil. However, it’s definitely using some other pathway because it’s subjectively different and it also stacks with other stimulants. Caffiene and modafinil both pair well with it and magnify the effects.

This is remarkable since I’m a nonresponder to almost all nootropics and herbs. And whenever I give Bacopa to friends of mine who don’t have CFS, it does nothing for them. But I have a friend with diagnosed fibro and an aquitance with diagnosed cfs. They both got strong subject mental clarity from bacopa too. I’m not sure why it would work so well for people in our cluster? Do you have any guesses?”

I actually did a post on it 13 months ago, and concluded “There are no studies with CFS/FM/IBS patients which would be ideal. My gut feeling (subjective) is that it is worth trying at 500-1000 mg/day.” It is relatively cheap on Amazon, so what is newly found about this? “Safety and tolerability data was well reported for 80% of studies with only 2.3% of all participants reporting mild side-effects.” [2016]

Microbial modulation of bacoside A biosynthetic pathway and systemic defense mechanism in Bacopa monnieri under Meloidogyne incognita stress[2017].
- “Bacoside A is considered as a major active component known to have 2016protective activities against morphine-induced cerebral toxicity, chemical-induced liver toxicity, and wound healing activity⁷^,8.”
Effect of Bacoside A on growth and biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa [2017]. “At a subminimum inhibitory concentration of 200 μg·mL^-1, Bacoside A significantly removed ∼88%-93% of bacterial biofilm developed on microtiter plates”
The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain [2017].
Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury [2017].
Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS Induced Model of Depression in Rat[2016].
Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial [2016]. “Statistically significant improvement was seen in the tests relating to the cognitive functions with use of Bacopa monnieri. Blood biochemistry also showed a significant increase in serum calcium levels (still within normal range).”
Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline[2016].
The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain[2017].

Bottom Line

There was been human studies and the reader report of dramatic improvement is very viable! Brain inflammation is common with CFS (typically seen in 75% of SPECT scans of CFS patients) and that this is effective in reaching the brain. A definite recommendation for anyone with brain fog.

Pingback: Cookbook Summary for the Brain Fogged | CFS Remission
- dlandersonod 6:45 pm on March 5, 2017
  
  Very interesting. Did the reader use the plain herb (which does seem very inexpensive) or a standardized extract in a capsule?
  
  I have a capsule maker and have made supplements from powders and such, so that’s not a problem. From the dosage suggested, I am assuming this is herb powder, non-standardized.

CFS Remission

Striving for true remission of CFS, chronic Lyme, FM, IBS etc

Bacopa Monnieri – Revisited

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