I have done summary of different DNA variations associated with CFS/IBS/FM before:
- DNA: Irritable Bowel Syndrome’s SNPs
- Fibromyalgia DNA SNP’s
- A Serotonin SNP in CFS
- Methylation Testing via 23andMe
- Case Study on Using DNA: Multiple Chemical Sensitivity
- Is CFS in your DNA?
My model has DNA + microbiome shifts –> Symptoms. The DNA reduces tolerances for swings of metabolites produced the microbiome and with a dysfunctional microbiome, some people are pushed over a threshold and develop symptoms. Fixing the microbiome is possible today, fixing DNA is likely a few decades off.
I happened to stumble across some PubMed studies involving hyperacusis, phonophobia and DNA Snps. This post looks at what I found for other conditions with hyperacusis or phonophobia.
Phonophobia (light sensitivity)
- “Dopamin Beta Hydroxylase gene +1603C>T polymorphism” [2016]
Hyperacusis (noise sensitivity)
The recognized associated conditions [2003] are
| Peripheral | Central |
|---|---|
| Bell’s palsy | Migraine |
| Ramsay-Hunt syndrome | Depression |
| Stapedectomy | Post-traumatic stress disorder |
| Perilymph fistula | Head injury |
| Lyme disease | |
| Williams syndrome |
- ” The most informative marker (69%) was D7S1870, followed by Hei (55%) and ELN 17/exon 18 (44%). The microdeletion was present in 56% and absent in 22% of patients….Two of the syndrome characteristics (an overfriendly personality and hyperacusis) were more frequent in the microdeletion group and these differences were statistically significant (p = 0.006 and p = 0.02, respectively).” [2010]
- ” OCRL gene deletion revealed involvement of several flanking repeat elements… hyperosmia and/or hyperacusis were reported recurrently.” [2015]
- “hemizygosity for a chromosomal deletion at 7q11.23… hyperacusis [1999]
CFS Remission 