What is comorbid with CFS/FM etc

Identified Sub Groups

From [2017] Study

  1. fibromyalgia, myofascial pain, multiple chemical hypersensitivity, sicca syndrome, epicondylitis, and thyroiditis
    1. “comprised mainly older women, with low educational level, unemployment, high levels of fatigue, and poor quality of life;”
  2. alterations of ligaments and subcutaneous tissue, hypovitaminosis D, psychopathology, ligamentous hyperlaxity, and endometriosis.
    1. comprised mainly older women, with low educational level, unemployment, high levels of fatigue, and poor quality of life;
  3. with hardly any comorbidities, comprising mainly younger women, university students or those already employed, with lower levels of fatigue, and better quality of life;
  4. poorly defined comorbidities;
  5. hypercholesterolemia.

Other Diagnosis

From 2000 Study

  • Self diagnosis of CFS [2013]
    • Sleep Disorder: 49.8% (especially obstructive sleep apnea syndrome)
    • Definite CFS: 23.3%
    • A psychiatric disorder was diagnosed in 45.2%; mostly mood and anxiety disorder.
  • Incidence of getting IBS:
    • chronic fatigue syndrome (CFS) –  92%;
    • fibromyalgia (FM) – 77%;
    • temporomandibular disorder (TMD) – 64%
  • Hyperacusis [2016]: Noise sensitivity
    • CFS – 3.2%
    • fibromyalgia – 4.2%
    • IBS  -4.8%
    • Anxiety Disorder – 47%
  • postural orthostatic tachycardia syndrome
    • CFS: 11% [2014]
    • Coeliac disease: 4% [2016]

Symptoms

From 2016 Australia Study according to the definition of CFS (Fukuda or  International Consensus Criteria). Percentage is given in ( )

Symptom Fukuda ICCa
Fatigue, n (%)
 Fatigued 162 (100.0) 171 (100.0)
 Postexertional malaise 68 (38.9) 171 (100.0)
 PENEe 25 (15.4) 171 (100.0)
Cognition, n (%)
 Confusion 52 (32.1) 69 (40.4)
 Disorientation 40 (24.7) 77 (45.0)
 Difficulty processing information 51 (31.5) 65 (38.0)
 Difficulty making decisions 53 (32.7) 66 (38.6)
 Slowed speech 46 (28.4) 75 (43.9)
 Difficulty reading 44 (27.2) 78 (45.6)
 Poor short-term memory 54 (33.3) 63 (36.8)
Pain, n (%)
 Headaches 51 (31.5) 64 (37.4)
 Muscle pain 53 (32.7) 65 (38.0)
 Joint pain 54 (33.3) 62 (36.3)
  Abdomen pain 42 (25.9) 71 (41.5)
 Chest pain 48 (29.6) 73 (42.7)
Sleep disturbances, n (%)
 Insomnia 46 (28.4) 69 (40.4)
 Prolonged sleep 51 (31.5) 57 (33.3)
 Reversed sleep 25 (15.4) 84 (49.1)
 Frequent awakenings 47 (29.1) 71 (41.5)
 Awakening earlier than expected 43 (26.5) 72 (42.1)
 Vivid dreams or nightmares 42 (25.9) 75 (43.9)
 Unrefreshed sleep 54 (33.3) 63 (36.8)
Sensory, perceptual, and motor disturbances, n (%)
 Inability to focus vision 47 (29.0) 69 (40.4)
 Sensitivitiesf 50 (30.9) 68 (39.8)
 Poor depth perception 30 (18.5) 78 (45.6)
 Muscle weakness 52 (32.1) 65 (38.0)
 Twitching 49 (30.3) 70 (40.9)
 Poor coordination 49 (30.3) 67 (39.2)
 Feeling unsteady on feet 44 (27.2) 70 (40.9)
Immune (infectious), n (%)
 Sore throat 45 (27.8) 73 (42.7)
 Tender lymph nodes 46 (28.4) 75 (43.9)
 Sinusitis 46 (28.4) 69 (40.4)
 Recurrent or persistent infections 46 (28.4) 71 (41.5)
Gastrointestinal and genitourinary, n (%)
 Nausea 44 (27.2) 73 (42.7)
 Abdominal pain 42 (25.9) 76 (44.4)
 Bloating 50 (30.9) 66 (38.6)
 Irritable bowelg 46 (28.4) 65 (38.0)
 Intolerancesh 45 (27.8) 68 (39.8)
 Urinary urgency or frequency 44 (27.2) 68 (39.8)
Cardiovascular, n (%)
 Orthostatic intolerancy 46 (28.4) 93 (54.4)
 Ataxiai 26 (16.1) 90 (52.6)
 Heart palpitations 42 (25.9) 65 (38.0)
 Light headedness 48 (29.6) 70 (40.9)
Respiratory, n (%)
 Air hunger 44 (27.2) 64 (37.4)
 Labored breathing 42 (25.9) 67 (39.2)
 Fatigue of chest muscles 50 (30.9) 68 (39.8)
Autonomic, n (%)
 Abnormal body temperature 41 (25.3) 66 (38.6)
 Fluctuating body temperature 48 (29.6) 67 (39.2)
 Sweating episodes 45 (27.8) 67 (39.2)
 Recurrent feverishness 43 (26.5) 75 (43.9)
 Cold extremities 45 (27.8) 72 (42.1)
 Intolerance of extremes temperature 50 (30.7) 67 (39.2)