SIBO and CFS/FM/IBS constantly shows a pattern of low or no Bifidobacterium, Lactobacillus and E.Coli. With these bacteria missing — how does it impact items like amino acids etc…
This is a technical post attempting to illustrate why things go wrong when they are missing — and why their absence leads to various supplements being needed (causation!)
All data is from datapunk.net ( Peter D’Adamo, currently a Distinguished Professor of Health Sciences at the University of Bridgeport, where he direct the Center of Excellence in Generative Medicine.)
ENDPRODUCTS For Bifidobacterium Genus
ENDPRODUCTS for Lactobacillus
ENDPRODUCTS for E.Coli
- Methanol
- Riboflavin
- Propionate
- Putrescine
- 5-hydroxytryptamine (5-HT, Serotonin) [parent]
- Pentanol
- Indole
- Cadaverine
Involved with the following KEGG Pathways (Escherichia genus used)
- 2-Oxocarboxylic acid metabolism
- ABC transporters
- Alanine, aspartate and glutamate metabolism
- Amino sugar and nucleotide sugar metabolism
- Aminoacyl-tRNA biosynthesis
- Arachidonic acid metabolism
- E. Coli only
- Arginine and proline metabolism
- Arginine biosynthesis
- Ascorbate and aldarate metabolism
- E. Coli only
- Bacterial chemotaxis
- E. Coli only
- Bacterial secretion system
- Base excision repair
- Benzoate degradation
- Lacto and E. Coli only
- Biosynthesis of amino acids
- Biosynthesis of antibiotics
- Biosynthesis of secondary metabolites
- Biosynthesis of siderophore group nonribosomal peptides
- E. Coli only
- Biosynthesis of unsaturated fatty acids
- Biotin metabolism
- Butanoate metabolism
- C5-Branched dibasic acid metabolism
- Bifi and E.Coli only
- Caprolactam degradation
- E. Coli only
- Carbapenem biosynthesis
- Bifi and E. Coli only
- Carbon metabolism
- Cationic antimicrobial peptide (CAMP) resistance
- Lacto only
- Chloroalkane and chloroalkene degradation
- Citrate cycle (TCA cycle)
- Cyanoamino acid metabolism
- Cysteine and methionine metabolism
- D-Alanine metabolism
- D-Glutamine and D-glutamate metabolism
- DNA replication
- Degradation of aromatic compounds
- Dioxin degradation
- E. Coli only
- Ether lipid metabolism
- E. Coli only
- Fatty acid biosynthesis
- Fatty acid degradation
- Fatty acid metabolism
- Flagellar assembly
- E. Coli only
- Fluorobenzoate degradation
- E. Coli only
- Folate biosynthesis
- Fructose and mannose metabolism
- Galactose metabolism
- Geraniol degradation
- E. Coli only
- Glutathione metabolism
- Glycerolipid metabolism
- Glycerophospholipid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / Gluconeogenesis
- Glyoxylate and dicarboxylate metabolism
- Histidine metabolism
- Homologous recombination
- Inositol phosphate metabolism
- Bifi and E. Coli only
- Insulin resistance
- Lysine biosynthesis
- Lysine degradation
- E. Coli only
- Metabolic pathways
- Methane metabolism
- Microbial metabolism in diverse environments
- Mismatch repair
- Monobactam biosynthesis
- Naphthalene degradation
- Nicotinate and nicotinamide metabolism
- Nitrogen metabolism
- Nonribosomal peptide structures
- Lacto and Bifi only
- Novobiocin biosynthesis
- Bifo only
- Nucleotide excision repair
- One carbon pool by folate
- Other glycan degradation
- Oxidative phosphorylation
- Pantothenate and CoA biosynthesis
- Pentose and glucuronate interconversions
- Pentose phosphate pathway
- Peptidoglycan biosynthesis
- Phenylalanine metabolism
- Phenylalanine, tyrosine and tryptophan biosynthesis
- Bifo only
- Phosphotransferase system (PTS)
- Polyketide sugar unit biosynthesis
- Bifo and E.Coli only
- Porphyrin and chlorophyll metabolism
- Bifo only
- Propanoate metabolism
- Protein export
- Purine metabolism
- Pyrimidine metabolism
- Pyruvate metabolism
- RNA degradation
- RNA polymerase
- Riboflavin metabolism
- Ribosome
- Secondary bile acid biosynthesis
- Bifo and Lacto only
- Selenocompound metabolism
- Sphingolipid metabolism
- Starch and sucrose metabolism
- Streptomycin biosynthesis
- Sulfur metabolism
- Sulfur relay system
- Lacto and E. Coli only
- Synthesis and degradation of ketone bodies
- Lacto only
- Taurine and hypotaurine metabolism
- Terpenoid backbone biosynthesis
- Thiamine metabolism
- Two-component system
- Tyrosine metabolism
- Ubiquinone and other terpenoid-quinone biosynthesis
- Bifo and E.Coli only
- Valine, leucine and isoleucine biosynthesis
- Valine, leucine and isoleucine degradation
- Vancomycin resistance
- Vitamin B6 metabolism
- Xylene degradation
- E. Coli only
- alpha-Linolenic acid metabolism
- E. Coli only
- beta-Alanine metabolism
- E. Coli only
- beta-Lactam resistance
Bottom Line
This is likely far above most readers brain-fog levels, but I believe it does illustrate that it is not just some inconsequential bacteria that you are missing. These three groups impact a lot of stuff and missing end products cascade across the body’s system.
- Missing Histidine metabolism –> Histamine sensitivity?
- Missing Degradation of aromatic compounds –> MCS?
CFS Remission 