Enhanced uBiome analysis of a UK reader

Patient History

“…began a gradual decline in health nearly 6years ago, root issue is unknown, was living with someone that had EBV at one point but never had it confirmed on herself, plenty of other potential causes around the time.  Daily at least from the outside reader does very well, reader has never been bedridden and can actually do quite a lot, nothing like her former self but maybe 50% in terms of energy. However, reader’s extremely headstrong which means reader can push through tough times at the expense of her future self. Current symptoms that are most prominent are night sweats, difficulty regulating body temperature, daily headaches which can progress to migraines if not caught with self-medication (migraleve.) Has had POTS confirmed by doctors, tends to get a sore spine and general ‘bone ache’ as reader describes it, this with night sweats and temperature difficulties can make sleep an issue (tends to wake frequently.) Extremely prone to sore throats and generating lots of mucus in this area, reader had her tonsils removed as a child after repeat throat infections, there was heavy antibiotic use at this time, first major illness. Has major issues around her menstrual cycle, incidence of headaches and likelihood of a migraine increase three-fold at this time, tends to feel very bloated and sore around the abdomen at this time. Investigated lots with endocrine and though they saw plenty of bizarre readings (i.e. prolactin 4 times normal reading), they were unwilling to do much. Has issues with constipation sometimes, digests fatty food poorly, diary and beans. Consuming these foods can result in painful bloating and diarrhoea. Regularly, reader will complain of what feels like something sitting on her chest and also random sharp pains in the same area.”

Standard Items


Biodiveristy:  92%ile (what seems to be the most common value for CFS patients)

Level of all Probiotics Explorer:  0% (none)

Firmicutes to Bacteroidetes ratio: 1.3: 1 (Normal is 2.1 to 1)

Note: The description in patient history and the relatively high bifidobacterium and less extreme Firmicutes to Bacteroidetes ratio than normally seen, suggests that this reader is in the least effective 10% — both from their history and their microbiome results.

High Bacteria Genus


Rare Bacteria Genus


I will revisit the rare bacteria in a later revision.

Bottom Line Suggestions

The lists below are done by merging the lists from the deep dives linked above. Some items may encourage one genus and discourage another genus — those are removed (unless it seems that it strongly predominates on one). The impact on Lactobacillus, Bifidobacterium and E.Coli are intentionally ignored [See this post for the logic]. This is all based on applying logic to the results of studies — thus theoretical. This is an addition (not a replacement) to this overview post.


  • Aspartame (Nutrasweet)
  • Berberine
  • Bifidobacterium longum
  • Fructooligosaccharides
  • High Fat Diet
  • Lactobacillus fermentum
  • L-Glutamic acid ( monosodium glutamate – MSG) and possibly gluten
  • L-Proline
  • L-Serine
  • Lysine supplements and foods
  • Minocycline
  • Penicillin
  • Saccharomyces boulardii
  • Walnuts


  • Enterococcus  faecalis probiotics
  • Fennel
  • Flaxseed
  • Gallate – Tea
  • Gluten free diet
  • High resistance starch
  • Inulin
  • Lactobacillus Casei
  • Lactobacillus kefiri LKF01
  • L-Phenylalanine (Good sources of phenylalanine are eggs, chicken, liver, beef, milk, and soybeans.[5])
  • lycheerambutanguaranakorlanpitomba, Spanish lime and ackee. [fam-Sapindaceae]
  • Polymannuronic acid
  • Resistant starch (type II & IV)

Based on Symptoms:


This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of CFS. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.