lassesen 5:15 pm on November 26, 2017  

Thyroidism and the CFS/FM/IBS microbiome

I recently did a post on blood pressures and the microbiome, a disturbance often seen with CFS/FM/IBS.  Hypothyroidism is also a common disturbance.

“autoimmune thyroid disease (AITD). The underlying mechanism comprises inherent genetic predisposition, abnormality of Th17 and Treg related biological molecules, and gut microbiota disorder. ” [2017]

“With a little help from my friends” – The role of microbiota in thyroid hormone metabolism and enterohepatic recycling [2017].

  • “Functional thyroid disorders were associated with bacterial overgrowth and a different microbial composition. Although thyroid metabolism was apparently disregarded, the interference of microbiota on peripheral iodothyronine homeostasis is an intriguing issue. In this review we focused on the interactions of intestinal microbiota with thyroid-related micronutrients and with the metabolic steps of endogenous and exogenous iodothyronines.”

Does microbiota composition affect thyroid homeostasis? [2015]

  • “real-time PCR showed obvious decrease of Bifidobacterium and Lactobacillus ((*) P < 0.05), and increase of Enterococcus ((*) P < 0.05) in the hyperthyroid group. ” [2014]

Grave’s Disease

  • “Common risk factors for GD (gender, smoking, stress, and pregnancy) reveal profound changes in the bacterial communities of the gut compared to that of healthy controls but a pathogenetic link between GD and dysbiosis has not yet been fully elucidated.” [2017]
  • ” Interestingly, all the environmental factors involved in Graves’ disease(GD) and Graves’ orbitopathy (GO) pathogenesis can alter the balance within the microorganisms located in the gut, and influence the immune system, in particular the proportions of regulatory Treg and inflammatory TH17 cells. It is hoped that investigating GD and GO pathogenesis from this novel aspect will identify new targets for prevention and treatment.” [2017]

Hashimoto’s thyroiditis

  • “We observed the declined abundance of Prevotella_9 and Dialister, while elevated genera of the diseased group included Escherichia-Shigella and Parasutterella. The alteration in gut microbial configuration was also monitored at the species level, which showed an increased abundance of E. coli in HT. Therefore, the current study is in agreement with the hypothesis that HT patients have intestinal microbial dysbiosis.” [2017]
  • Does the gut microbiota trigger Hashimoto‘s thyroiditis? [2014]
    “Further studies are clearly needed to test the hypothesis that the gut commensal microflora represents an important environmental factor triggering Hashimoto‘s thyroiditis.”
  • “Components of several viruses such as hepatitis C virus, human parvovirus B19, coxsackie virus and herpes virus are detected in the thyroid of Hashimoto’s thyroiditis patients. ” [2010]
  • “Similar changes have interestingly been detected in patients with Hashimoto’s thyroiditis (Cindoruk et al., 2002; Sasso et al., 2004), suggesting a pathogenic role of the leaky gut barrier in the development of Hashimoto’s thyroiditis.” [2012]

Bottom Line

Research is looking more and more at the microbiome aspect of thyroid dysregulation. (note all of the 2017 studies). We have had only a few studies done of the shifts. We see that the same low lactobacillus and bifidobacterium pattern is seen as with CFS/IBS/FM.  Enterococcus and Parasutterella  are overgrowth that I have already covered:

This hints some of the following actions may be useful in reducing the microbiome shift

Avoid

Take

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any disease. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.