Contributed data to the site consists of:

• 112 ubiome results uploaded from 90 different people
  • 49 of these have had symptoms added, 40 had general fatigue
  • 29 of these have had metabolites added (from ubiome site)

Observations for General Fatigue(40)

• 60% with unrefreshing sleep

Metabolite Function

With 65% either high or low

• Amino acid metabolism: D-Arginine and D-ornithine metabolism LOW
• Bacterial Abilities: Bacterial chemotaxis LOW
• Bacterial Abilities: Flagellar assembly LOW
• Secondary metabolite degradation: Toluene degradation JHIGH

Bacteria Class

• Actinobacteria
  • 10% low, 68% High
• Bacilli
  • 5% low , 68% High
• Betaproteobacteria
  • 58% with low,  25% with high
• Gammaproteobacteria
  • 10% with NONE, 70% with High

Bacteria Order

• Enterobacteriales
  • 18% None, 67% with HIGH
• Actinomycetales
  • 27% with none or low — 70% with High

Genus Level

• Lactobacillus
  • 28% with none, 70% with High
• Kluyvera
  • 20% with low,  65% with High
• Veillonella
  • 30% with Low – 65% with HIGH

Observations with Fatigue with Unrefreshing Sleep

Metabolite Function

With 65% high or low

• Amino acid metabolism: D-Arginine and D-ornithine metabolism Low (81%)
• Lipid metabolism: Steroid hormone biosynthesis High (72%)

Following had more than 65% high:

• Class
  • Actinobacteria
  • Bacilli
  • Gammaproteobacteria
• Order
  • Actinomycetales
  • Enterobacteriales
•  Family
  • Actinomycetaceae
  • Clostridiales Family XI. Incertae Sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Enterobacteriaceae
  • Lactobacillaceae
  • Prevotellaceae
• Genus
  • Actinomyces
  • Candidatus Soleaferrea
  • Kluyvera
  • Veillonella

Following had more than 65% low

• Order
  • Burkholderiales
•  Family
  • Sutterellaceae

Postural orthostatic tachycardia syndrome (POTS)

Metabolites with 65% high or low

• Amino acid metabolism: D-Arginine and D-ornithine metabolism Low (85%)
• Bacterial Abilities: Bacterial chemotaxis Low (76%)
• Bacterial Abilities: Bacterial motility proteins Low (68%)
• Bacterial Abilities: Flagellar assembly Low (76%)
• Bacterial Abilities: Lysosome High (68%)
• Lipid metabolism: alpha-Linolenic acid metabolism Low (76%)
• Lipid metabolism: Steroid hormone biosynthesis High (76%)
• Secondary metabolite degradation: Chlorocyclohexane and chlorobenzene degradation High (76%)

Bacteria

• Class
  • Actinobacteria
    • High
  • Gammaproteobacteria
    • High
• Order
  • Actinomycetales
    • High
  • Enterobacteriales
    • High
• Family
  • Enterobacteriaceae
    • High
  • Lactobacillaceae
    • High
  • Streptococcaceae
    • High
  • Veillonellaceae
    • High
• Genus
  • Pseudoflavonifractor
    • High
  • Streptococcus
    • High

Bottom Line

While our sample sizes are small, we do note some potential difference between those with general fatigue and POTS. Specifically:

• Pseudoflavonifractor and Streptococcus are more dominant and several others are less
• Lipid metabolism: alpha-Linolenic acid metabolism Low (76%)
  • Suggests that supplementing with ALA may help
  • I could find no studies using this supplement.
• Bacterial Abilities: Bacterial chemotaxis being low (poor communications/movement between cells) may be a significant factor for POTS.

The purpose of this post is to show how it is possible to identify metabolites and bacteria that are associated with certain symptoms (and in this case, for POTS, identify a supplement that may potentially help).

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any medical condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.