Attention-deficit syndrome and microbiome

Cognitive impairment is common in CF[2017]. A reader asked about ADHD, the hyperactivity of Attentiondeficit/hyperactivity disorder is not typically reported, but the attention disorder is. There is not much published yet, but a few items were interesting:

“Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with abnormalities in dopamine neurotransmission” [2017]

  • “In a cross-sectional observational study, 123 previously confirmed FMS patients were screened for adult ADHD using the World Health Organization Adult ADHD Self Report scale v1.1. … Of the 123 participants, 44.72% (N = 55) screened positive for adult ADHD. [2017]
  • CFS patients were assessed for childhood and adult ADHD by clinical interview and ADHD-specific scales. Psychopathological comorbidities were evaluated by clinical examination and questionnaires. Forty-seven of 158 CSF patients (29.7%) were diagnosed of childhood ADHD and in 33 (20.9%), the condition persisted into adulthood. CFS patients with adult ADHD had an earlier CSF onset, more severe anxiety and depression symptoms, and a higher risk of suicide than CFS patients without ADHD. ” [2012]
  • “Although the cause of primary Restless Leg Syndrome(RLS) is still unknown, there is a strong connection between central metabolism of iron as well as dopamine levels and RLS manifestation. ” [2011]

Bacteria Shifts

A recent article  [2017] reported the following shifts

  • Increased Bifidobacterium
  • Increase of Actinobacteria
  • Increased Bifidobacteriales
  • Increased Bifidobacteriaceae
  • Increased Bifidobacterium Longum
  • Increased Bifidobacterium adolescentis
  • Increased Bifidobacterium Pseuodocatenulatum
  • Decreased Firmicutes
  • Decreased Clostridia
  • Decreased Clostridiales
  • Decreased Ruminococcaceae
  • Decreased Subdoliggranulum
  • Decreased Ruminococcus
  • Decreased Acetivibrio
  • Decreased Lachnospiraceae
  • Decreased Coprococcus
  • Decreased Coprococcus eutactus
  • Decreased Eggerthella
  • Decreased Desulfovibrionales
  • Decreased Deltaproteobacteria
  • Increased Proteobacteria
  • Increased Porphyromonadaceae
  • Increased Odoribacter
  • Increased Parabacteroides
  • Increased Rikenellaceae
  • Increased Alistipes

uBiome Analysis Page

If you have uBiome, after uploading/logging in, go to:
http://microbiomeprescription.azurewebsites.net/condition/condition?code=3 

And you can see how closely you match the profile.

ADHD.PNG

As always with these conditions, recommendations are available to address the bacteria shifts associated with the conditions.

Bottom Line

The available study was done on Attentiondeficit AND  hyperactivity combined. We do not know which bacteria is associated with with. I would challenge the statisticians / AI / machine learning types to work from the above bacteria and the reported symptoms to try isolating those that are attention-deficit related.

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any medical condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.