This is a review of recent studies recorded on PubMed. The focus is on new information – so studies reporting prior information will rarely be mentioned.

• Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort [2018].
  • “the relative risk of IBS in 2013 related with use of antibiotics was 1.9”
• Irritable Bowel Syndrome Is Associated with an Increased Risk of Dementia: A Nationwide Population-Based Study [2016].
  • “patients with IBS were also more likely to develop either non- Alzheimer’s disease (AD) dementia or Alzheimer’s disease”
• Irritable bowel syndrome correlates with increased risk of Parkinson’s disease in Taiwan[2014].
  • ” The overall incidence of Parkinson’s disease in the IBS group was 1.76-fold higher than that in the non-IBS group”
• Aloe Vera is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis [2018].
  • “AV is effective and safe for the treatment of patients with IBS compared to placebo.”
• Association between Allergic Diseases and Irritable Bowel Syndrome: A Retrospective Study[2018].
  • “chronic urticaria  patients had a trend of increase in the detection of IBS compared to controls  (4.8x more often)”
• Relationships of Microbiome Markers With Extraintestinal, Psychological Distress and Gastrointestinal Symptoms, and Quality of Life in Women With Irritable Bowel Syndrome [2018].
  • “Lower extraintestinal pain was associated with increased Rikenellaceae, Christensenellaceae, Dehalobabacteriaceae, Oscillospiraceae, Mogibacteriaceae, Ruminococcaceae, Sutterellaceae, Desulfovibrionaceae, and Erysipelotrichaceae abundances.”
• Association between SERT insertion/deletion polymorphism and the risk of irritable bowel syndrome: A meta-analysis based on 7039 subjects [2018].
  • “Our findings indicated that the SERT insertion/deletion polymorphism may serve as a genetic biomarker of IBS in Asians and Caucasians.”
• Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome 2018].
  • “In patients with IBS-D with intestinal hyperpermeability following an enteric infection, oral dietary glutamine supplements dramatically and safely reduced all major IBS-related endpoints. “
• A microbial signature of psychological distress in irritable bowel syndrome [2018].
  • “Depression was negatively associated with Lachnospiraceae abundance (Spearman’s rho= -0.58, q= .018). Patients exceeding thresholds of distress, anxiety, depression and stress perception showed significantly higher abundances of Proteobacteria (q= .020 to .036). Patients with anxiety were characterized by elevated Bacteroidaceae (q= .036). “
• Fecal Microbiota Alterations Associated With Diarrhea-Predominant Irritable Bowel Syndrome.[2018]
  • “At the genus level, Lachnospira (P = 0.036), Parasutterella (P = 0.033), Lachnospiraceae_UCG-010 (P = 0.026), Ruminococcaceae_UCG-003 (P = 0.023), Lactobacillus (P = 0.021), Turicibacter (P = 0.022), Enterococcus (P = 0.002), Weissella (P = 0.048), Oxalobacter (P = 0.048), Oceanobacillus (P = 0.011), and Lachnospiraceae_NK4A136_group (P = 0.026) were significantly less abundant in IBS-D patients, while Faecalitalea (P = 0.012) was increased in IBS-D patients”
• Systematic review and meta-analysis: Efficacy of patented probiotic, VSL#3, in irritable bowel syndrome [2018].
  • ” there was a trend toward improvement in overall response with VSL#3, but no clear evidence effectiveness for IBS.”
• Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study.
  • “B. coagulans MTCC 5856 showed robust efficacy for the treatment of patients experiencing IBS symptoms with major depressive disorder. The improvement in depression and IBS symptoms was statistically significant and clinically meaningful. “
• Effect of Probiotic Administration Immediately and 1 Month after Colonoscopy in Diarrhea-predominant Irritable Bowel Syndrome Patients [2018].
  • “Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Bifidobacterium breve, Bifidobacterium longum, and Streptococcus thermophilus”
  • “Our results showed the beneficial effect of probiotics on symptoms of IBS, including stool consistency and frequency, production of gas, abdominal pain, and flatulence.”
  • IMHO Lactobacillus casei andBifidobacterium are likely the most beneficial one
• Microstructural White Matter Abnormalities in the Dorsal Cingulum of Adolescents with IBS.[2018]
• White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome [2018].

Bottom Line

We continue to find more and more any significant studies on microbiome shifts for IBS. A microbiome dysbiosis model fits well — including the increased risk of progression into dementia (which have greater dysbiosis).

I have updated the IBS Profile on http://microbiomeprescription.azurewebsites.net

Addendum: HOLIGOS for sale in US (Finally!):

It’s Human Milk Oligosaccharides — to be more precise, bio-identical oligosaccharides  which would be found in mother’s milk. We all know that a child that is breast fed usually grows up with less health problems than a bottle fed one.

See https://cfsremission.wordpress.com/2018/08/02/an-awesome-clinical-trial-for-ibs-folks/