For Canadian readers: Endocannabinoids

I have usually avoid looking at items that are advocated on ideological wishfulness. A reader forwarded me a link to “The Endocannabinoid System’s Intriguing Role in Gut Health” in the Townsend Letter, October 2018, so it’s time to check current reality.


Microbiome Aspect

The few available studies on mice found no impact on lean mice but significant impact on overweight mice [2015]

  •  increased Akkermansia muciniphila
  • decreased Roseburia
  • decreased Bacteroides/Prevotella
  • decreased Clostridium coccoides
  • decreased Clostridium leptum

And from [2017]

  • increased relative abundance of Akkermansia muciniphila
  • decreased Lanchnospiraceae and Erysipelotrichaceae

Bottom Line

The use of Endocannabinoids is not a simple use or do not use question. There can be negative effects reported with some studies for some conditions as shown in the table above.

It probable vector of benefit is Akkermansia muciniphila. There is active work in both Europe and the US on creating a Akkermansia muciniphila probiotic. Alternative ways of increasing Akkermansia muciniphila are covered in this earlier post.