Review of Antrantil

A reader asked me to review Antrantil which is often sold for digestive issues.

“Atrantíl is a nutraceutical made up of three botanical extracts that work by calming the gut with Peppermint Leaf (M. balsamea Willd extract), then soaking up hydrogen with Quebracho extract(flavonoid) and stops methane production with Horse Chestnut (Conker Tree extract).” [Product Site]


Unfortunately, there is nothing on PubMed (so no recognized published studies). It’s name is also very close to the name of some very different chemicals!

This is nice to have the three components listed because it allows us to determine a probable profile of it’s action.

Quebracho extract

Unfortunately, most of the literature deal with cattle and chicken

Horse Chestnut

There are some risks with this:
Acute Effusive Pericarditis due to Horse Chestnut Consumption. [2016]

“Properly processing horse chestnut seed extract removes esculin. The processed extract is considered generally safe when used for short periods of time. However, the extract can cause some side effects, including itching, nausea, gastrointestinal upset, muscle spasm, or headache.”  [NIH]

Bottom Line

There are no human studies on PubMed for two of the ingredients. These items fall under the general classification of gallic acid and tannins , which we know the general impact of on microbiomeprescription.

The marketing site claims “clinical testing with real patients was used to truly identify what combination of a multiple array of natural botanicals could have a positive impact with finding real and meaningful relief.” It appears to be based on unpublished studies of unknown quality.


45 x 550mg = 24 grams or 0.8 Ounce for $40.00


It is more economic to buy the components by far. It also allows you to see what the impact of each component is. I would avoid the horse chestnut (or do it under MD supervision).

For a digestive product to use a component know to cause “gastrointestinal upset” does raise my eyebrows. 

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any medical condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.