Noise Sensitivity and the Gut

Another interesting article showed up from AI detecting atypical articles on PubMed. I strongly suspect that this applies to noise sensitive individuals (
Hyperacusis). There are no studies on Hyperacusis microbiome

Effects of chronic noise on glucose metabolism and gut microbiota-host inflammatory homeostasis in rats. [2016]

 Chronic noise exposure increased blood glucose and corticosterone levels for at least 14 days after cessation of noise. Stressed rats also exhibited elevated levels of glycogen and triglyceride in the liver and impaired hepatic insulin production via insulin-induced insulin receptor/insulin receptor substrate 1/glycogen synthase kinase 3β signalling, which persisted for 3-14 days after cessation of noise exposure. Chronic noise altered the percentage of Proteobacteria and Actinobacteria in the gut, increasing Roseburia but decreasing Faecalibacterium levels in the cecum relative to controls. Immunoglobulin A, interleukin 1β, and tumor necrosis factor α levels were also elevated in the intestine of these animals, corresponding to noise-induced abnormalities in glucose regulation and insulin sensitivity. These results suggest that lifelong environmental noise exposure could have cumulative effects on diabetes onset and development resulting from alterations in gut microbiota composition and intestinal inflammation.

Effects of chronic noise on glucose metabolism and gut microbiota-host inflammatory homeostasis in rats. [2016]

Human Studies

 IL-12 levels increased, whereas the NKT cell population decreased with increasing noise levels. The results further suggested that cortisol levels are more influenced by the subject’s sensitivity to noise than to the level of chronic road traffic noise. Therefore, noise appears to have the largest effect on IL-12 levels as well as the population and activity of NKT cells. In conclusion, our results suggest that low-level road traffic noise and sensitivity to noise can affect health by causing changes in the immune response through mechanisms other than increased cortisol.

Effects of self-reported sensitivity and road-traffic noise levels on the immune system. [2017]

Exposure to noise in work environment increases the incidence of tension and inappropriate behavior associated with aggression. Controlling noise through use of protective equipment might reduce the deleterious effects of noise on workers.

Effect of Chronic Noise Exposure on Aggressive Behavior of Automotive Industry Workers. [2018]

Note that hypertension(high blood pressure) is associated with these microbiome shifts

Bottom Line

I suspect there is a feedback cycle between the microbiome and
hyperacusis.

Looking at contributed samples that reported hyperacusis (some 73!), we see some significant patterns;

We do not know if the shifts caused the hyperacusis OR the hyperacusis caused the shifts OR there was a feedback cycle between the two,