A reader asked me to assemble a list of known DNA mutations. In my post on Multiple Chemical Sensitivity we see that the MTHFR gene is associated with abnormal blood clotting ( US National Library of Medicine). Coagulation issues are strongly associated with brain fog.
Since this type of question often leads to “where can I get appropriate testing done?” Coagulation issues are outside of “my wheel house” except for being aware of them and knowing about the specific mutation that I have.
Thrombophilia Mutation Panel seems to be the most detailed all-in-one test:
- Factor V deficiency
- Budd-Chiari syndrome (BDCHS)
- Homocysteinemia due to MTHFR deficiency
- Ischemic stroke
- Neural tube defects, folate-sensitive (NTDFS)
- Pregnancy loss, recurrent, susceptibility to, 2 (RPRGL2)
- Prothrombin deficiency, congenital
- Recurrent abortion (RPRGL1)
- Schizophrenia (SCZD)
- Thrombophilia due to activated protein C resistance (THPH2)
- Venous thrombosis (THPH1), lab preferred: Thrombophilia
For general background read:
- Overview of Coagulation Disorders
- Overview of Thrombotic Disorders
- Note that for some conditions, i.e. Prothrombin (Factor II) 20210 Gene Mutation
- “The diagnosis is made by genetic analysis of the prothrombin 20210 gene using blood samples. ” which suggests that 23AndMe style information may be insufficient.
- There are some mutations that only occurs in people with Jewish DNA.
