Spam, spam, spam – Gupta!

I got this on my facebook page:

Given how long this program been running, I would expect studies and results on PubMed — there are ZERO — opps wrong, see bottom.

Their site banners: “Gupta Program Brain Retraining™ Is A Powerful Revolutionary New Program For Chronic Conditions.”

  • ah, brain retraining — these conditions are all in your head!
  • Success stories — two key phrases: Placebo Effect, Lack of external verification of testimonies,

Testimonies are meaningless without a control study (ideally published on PubMed — where there is nothing). Of 1000 people who signed off, with MD verified medical condition X, what was the result? For many published studies, I see 15% of control group improved (your testimony!!) and 28% of those on treatment.

Bottom Line

Lack of peer-reviewed published control studies – means a big thumb down for the scientist writing here..


A reader found some studies were on pubmed which I could not filter from studies done by other Guptas!.

 “a novel hypothesis for chronic fatigue syndrome (CFS) is proposed….
followed by the patient’s experience of the illness. ”

Gupta, A. (2002). Unconscious amygdalar fear conditioning in a subset of chronic fatigue syndrome patients. Medical Hypotheses 59(6), 727–735 [2002]

Note that this is proposing a hypothesis based on a single patient’s experience.

Of the 44 patients randomly assigned who completed baseline assessments, 21 patients completed the study (14 in the standard care group and 7 in the study group). Median age was 48 years (range, 27-56 years), and female subjects comprised 91% of the group. Analyses demonstrated statistically significant improvements in scores for physical health, energy, pain, symptom distress, and fatigue in patients who received the amygdala retraining compared with standard care.

Toussaint et al. (2012).A mind-body technique for symptoms related to fibromyalgia and chronic fatigue. Explore (NY). 2012 Mar-Apr;8(2):92-8. doi: 10.1016/j.explore.2011.12.003.

So, 7 of 44 completed the study. All of the measures were subjective self reporting (thus very prone to placebo effect)

I suffered from ME (chronic fatigue syndrome) for three years. I spent years researching this mysterious illness to understand the causes, focusing on the brain neurology of conditioned traumas in the amygdala. I cured myself of the condition and wrote a medical hypothesis as to the cause of ME which was published in 2002. …

Limitations No control group or placebo group was used, and future studies would need to incorporate this. No standardised tools were used, and randomised collection was not employed. Researcher bias, and the effects of researcher/ practitioner enthusiasm, were significant confounding factors, as were participants’ possible use of concurrent therapies. Sample bias was significant in that those completing the programme may have shown more motivation and commitment.

Can amygdala retraining techniques improve the wellbeing of patients with chronic fatigue syndrome – A clinical audit of subjective outcomes in a small sample. Journal of holistic healthcare, 7(2).