Studies have shown there are differences between depression from Chronic Fatigue Syndrome and classic depression as well as the microbiome findings:

https://cfsremission.wordpress.com/2018/03/10/depression-and-the-microbiome-revisited/

An older model that I have used has been hypoxia a.k.a. Altitude Sickness. The reason were originally the overlap of many symptoms between CFS and Altitude Sickness. After that, I was tested for Hypercoagulation by Hemex Labs (Coagulation specialists) and found that I was — in fact hypercoagulated. For some blood draws the nurse ended up trying 8 different sites before they could get enough blood! Talk about thick blood!

A study at that time found 85% of CFS/ME patients were hypercoagulated with many improving greatly from low dosage heparin.

And thick blood means slow moving blood and thus the delivery rate of oxygen goes down.

Observed behaviors and personal anecdotes suggest that the initial mood experienced at altitude is euphoria, followed by depression. With time, individuals may also become quarrelsome, irritable, anxious, and apathetic (Van Liere and Stickney, 1963). Unfortunately, although disturbances in emotional control have been noticed at altitude for decades, there are few quantitative studies assessing mood changes at altitude.

The Effect of Altitude on Cognitive Performance and Mood States

So I have low oxygen levels – What can I do?

The ‘obvious’ suggestions rarely work. An example:

• Oxygen tank:
  • Will not work for slow blood. The blood may already be saturated with oxygen
  • Will not work if there are hemoglobin issues. The blood cannot carry more

IMHO there is not one universal solution, the following are possibly (depends on the person’s actual conditions)

• Items that improves blood flow (speed of delivery)
• Items that “clears out the sewers” (aka blood vessels)
  • Nattokinase
  • Lumbrokinase
  • Serrapeptase
  • Bromelain
• Nootropics
  • Piracetam (my favorite is Piracetam + heparin cocktail)
• Other Supplements (see this post https://cfsremission.wordpress.com/2015/09/08/thick-blood-supplements-for-cfs/ )
  • Alpha Lipoic Acid
  • Boswelia Gum
  • Centella Asiatica [Gotu kola]
  • Coenzyme Q10
  •  Ginseng
  • Grape Seed Extract
  • Licorice
  • Turmeric especially with black pepper added in
• Vascular Dilators (expand the size of the blood vessels) see this site for more items
  • Niacin (regular – aka flushing, aka, itches like…)
  • Garlic
  • Cocoa
  • Magnesium
  • L-Arginine
  • Coenzyme Q10
• Testing for and treating coagulation issues, see this post: https://cfsremission.wordpress.com/2018/05/20/post-m-options-for-testing-for-coagulation-issues-defects/

Bottom Line

The above looks at items that in terms of a delivery network could be described below

• Increases the speed on the highways (blood flow)
• Adds more lanes to the highways ( Vascular Dilators )
• Repairs the road surface (120km/hr on a pothole road does not do it)
• Increase the load each trunk can carry
• Improves the routing and utilization of each truck (nootropics)

The goods being delivered is oxygen, the road system is your body.