Candida – What Studies Find

The Candida species play a role in a healthy body. It is when there is too many that problems start. A friend asked me to put together what we know based on published studies only, no urban-medical-beliefs.

  • There is an increased total fungal load particularly of Candida and Malassezia species in the faeces and mucosa of Crohn’s disease patients, and a lower fungal diversity in the faeces of ulcerative colitis patients. [2019]

Herbs

Antifungal efficacy of herbs (2019). The larger the numbers above, the more effective it is

So to translate into familiar terms, in decreasing effectiveness:

  • Garlic vine ( Echinophora platybola )
  • Benth ( Pogostemon parviflorus )
  • Ashwagandha (Withania somnifera) – Easy to get
  • Turmeric (Curcuma longa) – Easy to get
  • Asthma-plant (Ayurveda- Euphorbia hirta )
  • Ginger (Zingiber officinale )
  • Henna ( Lawsonia inermis )
  • Swertia ( Ayurveda – Swertia chirata )

These are cited, with further studies on this page (in french) and includes the above with links to multiple additional studies for each.

Other Stuff

  • ” It can be concluded that monolaurin has a potential antifungal activity against C. albicans and can modulate the pro-inflammatory response of the host. ” [2016]
  • ” The difference between the groups [chlorhexidine, lactobacillus probiotics, coconut oil] was not statistically significant (Chi-square value 7.42, P value 0.06). ” [2016]
  • ” Eucommia ulmoides, Polygonum cuspidatum, Poria cocos and Uncaria rhyncophylla showed activity against both bacterial and fungal strains, indicating their broad spectrum of activity. ” [2013]
  • ” Data show that mustard [i.e. Turmeric] and coconut oil seem to be effective as in these the spore germination was poor. ” 1992
  • Pau D’Arco ( Tabebuia ) – Studies found no significant effect [1994]
    • Tabebuia avellanedae (methanol extract), with MIC varying from 0.06 to 0.001 mg/mL;  ” [2010] – this is a fraction of the effectiveness of items above.

Probiotics

  • Enterococcus Faecalis appears effective [2014] (available as probiotic)
  • Lactobacillus GG, Lactobacillus rhamnosus LC705 and Propionibacterium freudenreichii ssp. shermanii JS was shown to be an effective means of controlling oral Candida and hypo‐salivation in the elderly (Hatakka et al2007). [2016]
  • Bacillus subtilis exhibited clear zones of inhibition for Candida albicans and Candida parapsilosis but not for Candida krusei. [2016]

Sookkhee et al., in 2001, studied the effects on Candida albicans growth of different lactic-acid bacteria isolated from the oral cavity of volunteers and found that two strains, Lactobacillus paracasei and Lactobacillus rhamnosus, had the strongest effect on the yeast [44].
Lactobacillus reuteri is a promising bacterium (especially DSM 17938 and ATCC PTA 5289) for its anti-Candida properties, confirmed by several studies. In one of these, Lactobacillus reuteri was demonstrated to be able to reduce Candida load in vivo through co-aggregation, modification of oral pH with production of lactic acid and other organic acids that inhibit the virulence of Candida cells, and production of H2O2 [45].
In a recent in vitro study by Coman et al. (2014), the strains Lactobacillus rhamnosus IMC 501 and lactobacillus paracasei IMC 502, alone or in combination, showed an inhibitory effect on Candida spp. growth [46].
Lactobacillus delbrueckii ssp. bulgaricus B1 and Lactobacillus delbrueckii ssp. bulgaricus TAB2 were found to fight Candida, releasing high amounts of lactic acid [47].Recently, it was found that Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 modulate Candida glabrata virulence, through the complete inhibition of fungal biofilms [48].In addition, Lactobacillus acidophilus ATCC 4356 was found to inhibit the biofilm formation of fungus through in vitro experiments [49]. Biofilm formation is probably reduced through the production of substances called “bacteriocins” by probiotics. Wannun et al. reported the isolation of a bacteriocin, called “fermencin SD11”, from Lactobacillus fermentum SD11, a human oral Lactobacillus, which has a strong inhibitory effect on oral Candida cells [50].

Effect of Probiotics on Oral Candidiasis: A Systematic Review and Meta-Analysis 2019

Histamine Caution

  • All Lactobacillus Reuteri are histamine producers.
  • Many Bacillus subtilis are histamine producers [2007]

Lactobacillus rhamnosus appears not to be a histamine producer and reduces histamines [2011]