I have done a few prior post on this, listed below. At a high level, this does not mean that ME/CFS is a DNA disease instead of a microbiome dysfunction, rather it paints a richer picture.

The microbiome and your DNA interact with each other. Your microbiome is actually much richer/more complex than your DNA. There is evidence that the microbiome and DNA cooperate with each other. So, ME/CFS is a “perfect storm” scenario. You need the right DNA mutations to coincide with the right microbiome dysfunction. To the best of my knowledge, no studies have been done combining the two 😦 .

I focus on the microbiome because it is much more actionable then DNA. You can change the microbiome, i.e. pull your ship caught in the perfect storm into a sheltered harbor…. The ship may still have its defect (DNA) issues, but without the storm beating on it, it won’t sink.

Past Posts

• 2013 – Is CFS in your DNA?
• DNA: Irritable Bowel Syndrome’s SNPs
• Fibromyalgia DNA SNP’s
• A Serotonin SNP in CFS
• Methylation Testing via 23andMe
• Case Study on Using DNA: Multiple Chemical Sensitivity

Extracts from Recent Studies

• MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variants [2019]
  • Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness. [2017]
  • Mitochondrial dysfunction in a family with psychosis and chronic fatigue syndrome. [2017]
  • Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms.[2016]
  • Is chronic fatigue syndrome truly associated with haplogroups or mtDNA single nucleotide polymorphisms? [2016]
  • Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome. [2016]
• Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study. [2019]
• Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients. [2016]
• A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. [2016]
• Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome. [2016]
• Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome. [2016]
• Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype. [2015]
• Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome. [2015]
• Use of single-nucleotide polymorphisms (SNPs) to distinguish gene expression subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). [2014]
• A possible genetic association with chronic fatigue in primary Sjögren’s syndrome: a candidate gene study. [2014]
• Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data. [2011]
• Polymorphisms of adrenergic cardiovascular control genes are associated with adolescent chronic fatigue syndrome. [2011]
• Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome. [2011]
• A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome. [2010]
• Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome. [2006]

Someone care to extract a summary?

In the past, I have walked thru each article and produced a checklist of SNPs cited with the matching 23andMe item (if they reports it) and even recall creating a template on a 3rd party analysis site. I do not have the time for this at present.

If a reader care to do this and write up a guest post, I would love it!

In time, I would love to add these SNPs to the microbiome site to try to detect which dna-bacteria-symptoms combinations are significant. It will be another step into being uber-specific on why you have certain symptoms and thus have specific treatment based on your DNA, microbiome and symptoms.

I have added maternal haplotypes to the symptoms list now — if you know yours, please associate it with your sample. The types entered are the common one from this page.