Neuroinflammation – Options

Neuroinflammation is defined by Wikipedia as “inflammation of the nervous tissue. It may be initiated in response to a variety of cues, including infection, traumatic brain injury,[1] toxic metabolites, or autoimmunity.[2

Neuroinflammation is defined as an inflammatory response within the brain or spinal cord. This inflammation is mediated by the production of cytokines, chemokines, reactive oxygen species, and secondary messengers. These mediators are produced by resident CNS glia (microglia and astrocytes), endothelial cells, and peripherally derived immune cells. There are immune, physiological, biochemical, and psychological consequences of these neuroinflammatory responses. Moreover, the degree of neuroinflammation depends on the context, duration, and course of the primary stimulus or insult (Figure 1)

Neuroinflammation: The Devil is in the Details [2016]
Note that IL-1 is on both sides

In terms of ME/CFS where stress is a very common cause/contributor

  • “the response to chronic or traumatic stressors. Traumatic or chronic stressors appear to promote a more neuroinflammatory profile that involves both resident microglia and bone marrow-derived macrophages (Wohleb et al. 2014a) ” [2016] Which leads to removal of chronic stress as a key treatment choice (sometimes called, re-adjusting expectations or giving the finger to those with high expectations of you!)
  • “Neuroinflammation is present in widespread brain areas in CFS/ME patients and was associated with the severity of neuropsychologic symptoms.” [2014]

For more technical details, read the article cited above.
I would also advocate bookmarking the Journal of Neuroinflammation

Neuroinflammation and the Microbiome

Review studies on pubmed we find:

Bottom Line

There are many items that will help with reducing neuroinflammation. In terms of priorities, removing contributors should be a high priority. “Plug the hole in the dyke, do not send for more buckets!” This likely include some significant items:

  • Removal of personal stress (letting go, ” Que Sera, Sera -what will be, will be”)
  • Removal of environment stress
  • Work on oral health

All of these can be challenging. For me, we have moved to 25 acres in the country, local organic food, no work email on my phone or home computer, blocked all phone numbers except for a few, employer has no issue with my cutting hours as needed – 20% of the staff just work 4 days a week by choice.

A friend is Spain would love to get some of the old rural monasteries or nuneries re-purpose as sanatoriums for ME/CFS people. I very much agree with her — that would be awesome.